Activation-induced cell death in CAR-T cell therapy

Engineered T cells expressing chimeric antigen receptors (CARs) with tumor specificity have shown remarkable therapeutic effects on hematologic malignancies. However, CAR-T cells are less effective on solid tumors mainly due to the weak persistence of CAR-T cells, which might be caused by T cell dea...

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Veröffentlicht in:	Human cell : official journal of Human Cell Research Society 2022-03, Vol.35 (2), p.441-447
Hauptverfasser:	Huan, Tian, Chen, Dongfeng, Liu, Guodong, Zhang, Hailing, Wang, Xiaoyan, Wu, Zhi, Wu, Yan, Xu, Qinggang, Yu, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Apoptosis Biomedical and Life Sciences Cell activation Cell Biology Cell Death Cell therapy Cell- and Tissue-Based Therapy Chimeric antigen receptors Death receptors Gynecology Humans Immunotherapy, Adoptive Life Sciences Lymphocytes Lymphocytes T Molecular modelling Neoplasms - therapy Oncology Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - metabolism Reproductive Medicine Review Article Solid tumors Stem Cells Surgery T-Lymphocytes - metabolism Tumors
Online-Zugang:	Volltext
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