Palladium‐Catalyzed N3‐Directed C−H Halogenation of N9‐Arylpurines and Azapurines

A palladium‐catalyzed direct ortho‐halogenation of N9‐arylpurines was developed by using N‐halogenated succinimide (NBS/NCS/NIS) as the halogenation reagents. The current procedure offers a late‐stage strategy to generate N9‐(ortho‐haloaryl)purines in moderate to excellent yields. The protocol was a...

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Veröffentlicht in:	European journal of organic chemistry 2022-02, Vol.2022 (8), p.n/a
Hauptverfasser:	Hu, Junbin, Wang, Chenxing, Yu, Mingwu, Zhang, Shaojuan, Chen, Ning, Du, Hongguang
Format:	Artikel
Sprache:	eng
Schlagworte:	C−H activation Halogenation Late-stage functionalization Palladium Palladium-catalyzed Purines Reagents Substrates
Online-Zugang:	Volltext
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