Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4

Identifying novel molecules as potential kinase inhibitors are gaining significant attention globally. The present study suggests Myricetin as a potential inhibitor of microtubule‐affinity regulating kinase (MARK4), adding another molecule to the existing list of anticancer therapeutics. MARK4 regul...

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Veröffentlicht in:	Journal of cellular biochemistry 2022-02, Vol.123 (2), p.359-374
Hauptverfasser:	Anwar, Saleha, Khan, Shama, Anjum, Farah, Shamsi, Anas, Khan, Parvez, Fatima, Hera, Shafie, Alaa, Islam, Asimul, Hassan, Md. Imtaiyaz
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Affinity Apoptosis Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Cancer cancer cell lines Cell division Cell proliferation drug discovery Electrostatic properties Enthalpy Entropy Female Flavonoids - chemistry Flavonoids - pharmacology Fluorescence HEK293 Cells Humans isothermal titration calorimetry kinase inhibitor Kinases Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - enzymology MCF-7 Cells Molecular docking Molecular dynamics molecular dynamics simulation Molecular structure Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - chemistry Neoplasm Proteins - metabolism Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - chemistry Protein Serine-Threonine Kinases - metabolism Titration
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