Radical-mediated thiol-ene 'click' reactions in deep eutectic solvents for bioconjugation

Herein, we report the first application of deep eutectic solvents (DESs) in radical-mediated hydrothiolation reactions. Under UV and atmospheric-oxygen mediated conditions, the thiol-ene reaction was applied to amino acid and peptide ligation in DESs. The conditions facilitate highly-efficient synth...

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Veröffentlicht in:	Green chemistry : an international journal and green chemistry resource : GC 2022-02, Vol.24 (4), p.1456-1462
Hauptverfasser:	Nolan, Mark D, Mezzetta, Andrea, Guazzelli, Lorenzo, Scanlan, Eoin M
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Amino acids Angiotensin Angiotensin-converting enzyme 2 COVID-19 Eutectic reactions Fluorescence Glycosylation Green chemistry Infectivity Labeling Peptidyl-dipeptidase A Severe acute respiratory syndrome coronavirus 2 Solvents Spike protein
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