LC-MS/MS determination of glimepiride in human plasma with a high recovery at picogram scale: Pharmacokinetic study after oral administration

Although glimepiride (GLM) is the first-line treatment of Type II diabetes, low extraction recovery is still a significant limitation in previous plasma analysis methods. An optimized solid-phase extraction method of GLM in human plasma with excellent extraction recovery, 100 ± 0.06%, was achieved u...

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Veröffentlicht in:	Acta chromatographica 2022-01, Vol.34 (1), p.12-17
Hauptverfasser:	Kammoun, Ahmed K., Awan, Zuhier Ahmed, Elawady, Tarek, Khedr, Alaa, El-Awady, Mohamed I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood plasma Diabetes mellitus Dichloromethane Ionization Ions Liquid chromatography Mass spectrometry Mass spectroscopy Oral administration Pharmacokinetics Pharmacology Plasma Recovery Selectivity Solid phases
Online-Zugang:	Volltext
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