Influence of topical corticosteroids on malignant transformation of oral lichen planus
Background Oral lichen planus (OLP) is considered an oral potentially malignant disorder. While OLP has been associated with the development of oral squamous cell carcinoma (OSCC), little is known about the role of topical corticosteroids therapy (TCT) in the promotion of carcinogenesis. The study a...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2022-02, Vol.51 (2), p.188-193 |
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| container_title | Journal of oral pathology & medicine |
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| creator | Bindakhil, Mohammed Akintoye, Sunday Corby, Patricia Stoopler, Eric T. Greenberg, Martin S. Shanti, Rabie Tanaka, Takako I. Sollecito, Thomas P. |
| description | Background
Oral lichen planus (OLP) is considered an oral potentially malignant disorder. While OLP has been associated with the development of oral squamous cell carcinoma (OSCC), little is known about the role of topical corticosteroids therapy (TCT) in the promotion of carcinogenesis. The study aimed to determine if TCT influences the time of malignant transformation of OLP to OSCC. The study also investigates this correlation in the presence or absence of Candida overgrowth, and in the context of conventional OSCC risk factors such as smoking, alcohol use, and male gender.
Methods
A retrospective analysis of electronic health records at a tertiary care academic medical center was performed. Patients with OLP and OSCC were considered for inclusion. The diagnosis of OLP required both clinical and histological documentation.
Results
Eighty‐two patients met inclusion criteria, consisting of 48 women (58.25%) and 34 men (41.5%) and the mean patient age was 65.9 years (SD = 13.25). Forty‐five patients (54.9%) received TCT for OLP before they developed OSCC. The time between the OLP and OSCC diagnoses increased by four years in patients who received topical steroid therapy for OLP (p |
| doi_str_mv | 10.1111/jop.13257 |
| format | Article |
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Oral lichen planus (OLP) is considered an oral potentially malignant disorder. While OLP has been associated with the development of oral squamous cell carcinoma (OSCC), little is known about the role of topical corticosteroids therapy (TCT) in the promotion of carcinogenesis. The study aimed to determine if TCT influences the time of malignant transformation of OLP to OSCC. The study also investigates this correlation in the presence or absence of Candida overgrowth, and in the context of conventional OSCC risk factors such as smoking, alcohol use, and male gender.
Methods
A retrospective analysis of electronic health records at a tertiary care academic medical center was performed. Patients with OLP and OSCC were considered for inclusion. The diagnosis of OLP required both clinical and histological documentation.
Results
Eighty‐two patients met inclusion criteria, consisting of 48 women (58.25%) and 34 men (41.5%) and the mean patient age was 65.9 years (SD = 13.25). Forty‐five patients (54.9%) received TCT for OLP before they developed OSCC. The time between the OLP and OSCC diagnoses increased by four years in patients who received topical steroid therapy for OLP (p < 0.001) and decreased by three years (p = 0.010) in those with Candida overgrowth. Gender, smoking, and alcohol use did not have a statistically significant influence on the time between OLP and OSCC.
Conclusion
The management of OLP using TCT potentially delayed cancer development in our study. Conversely, it appears that Candida may play a role in the field cancerization of OLP patients.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.13257</identifier><identifier>PMID: 34748663</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adrenal Cortex Hormones - adverse effects ; Aged ; Alcohol use ; Candida ; Carcinogenesis ; Carcinoma, Squamous Cell - drug therapy ; Cell Transformation, Neoplastic ; Corticosteroids ; Electronic medical records ; Female ; Gender ; Head and Neck Neoplasms ; Humans ; Lichen planus ; Lichen Planus, Oral - drug therapy ; Male ; malignant transformation ; Mouth Neoplasms - drug therapy ; Oral cancer ; Oral carcinoma ; oral lichen planus ; Oral squamous cell carcinoma ; Patients ; Retrospective Studies ; Risk factors ; Smoking ; Squamous cell carcinoma ; Statistical analysis ; Steroids ; topical corticosteroids</subject><ispartof>Journal of oral pathology & medicine, 2022-02, Vol.51 (2), p.188-193</ispartof><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-42a31d3c4a70e0f510e99ad4c99aa227afc848995dd5652a27650727e12027883</citedby><cites>FETCH-LOGICAL-c3537-42a31d3c4a70e0f510e99ad4c99aa227afc848995dd5652a27650727e12027883</cites><orcidid>0000-0001-8432-3111</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjop.13257$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjop.13257$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34748663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bindakhil, Mohammed</creatorcontrib><creatorcontrib>Akintoye, Sunday</creatorcontrib><creatorcontrib>Corby, Patricia</creatorcontrib><creatorcontrib>Stoopler, Eric T.</creatorcontrib><creatorcontrib>Greenberg, Martin S.</creatorcontrib><creatorcontrib>Shanti, Rabie</creatorcontrib><creatorcontrib>Tanaka, Takako I.</creatorcontrib><creatorcontrib>Sollecito, Thomas P.</creatorcontrib><title>Influence of topical corticosteroids on malignant transformation of oral lichen planus</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Background
Oral lichen planus (OLP) is considered an oral potentially malignant disorder. While OLP has been associated with the development of oral squamous cell carcinoma (OSCC), little is known about the role of topical corticosteroids therapy (TCT) in the promotion of carcinogenesis. The study aimed to determine if TCT influences the time of malignant transformation of OLP to OSCC. The study also investigates this correlation in the presence or absence of Candida overgrowth, and in the context of conventional OSCC risk factors such as smoking, alcohol use, and male gender.
Methods
A retrospective analysis of electronic health records at a tertiary care academic medical center was performed. Patients with OLP and OSCC were considered for inclusion. The diagnosis of OLP required both clinical and histological documentation.
Results
Eighty‐two patients met inclusion criteria, consisting of 48 women (58.25%) and 34 men (41.5%) and the mean patient age was 65.9 years (SD = 13.25). Forty‐five patients (54.9%) received TCT for OLP before they developed OSCC. The time between the OLP and OSCC diagnoses increased by four years in patients who received topical steroid therapy for OLP (p < 0.001) and decreased by three years (p = 0.010) in those with Candida overgrowth. Gender, smoking, and alcohol use did not have a statistically significant influence on the time between OLP and OSCC.
Conclusion
The management of OLP using TCT potentially delayed cancer development in our study. Conversely, it appears that Candida may play a role in the field cancerization of OLP patients.</description><subject>Adrenal Cortex Hormones - adverse effects</subject><subject>Aged</subject><subject>Alcohol use</subject><subject>Candida</subject><subject>Carcinogenesis</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Cell Transformation, Neoplastic</subject><subject>Corticosteroids</subject><subject>Electronic medical records</subject><subject>Female</subject><subject>Gender</subject><subject>Head and Neck Neoplasms</subject><subject>Humans</subject><subject>Lichen planus</subject><subject>Lichen Planus, Oral - drug therapy</subject><subject>Male</subject><subject>malignant transformation</subject><subject>Mouth Neoplasms - drug therapy</subject><subject>Oral cancer</subject><subject>Oral carcinoma</subject><subject>oral lichen planus</subject><subject>Oral squamous cell carcinoma</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Smoking</subject><subject>Squamous cell carcinoma</subject><subject>Statistical analysis</subject><subject>Steroids</subject><subject>topical corticosteroids</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAURS0EoqUw8AdQJCaGtM9fcTKiio-iSmUA1sg4DrhK7GAnQv33GFLYeIPf4HPPky5C5xjmOM5i67o5poSLAzTFGUAKArNDNIUCWEo4JhN0EsIWAAvK8DGaUCZYnmV0il5Wtm4GbZVOXJ30rjNKNolyvjfKhV57Z6qQOJu0sjFvVto-6b20oXa-lb2JHzHmfMw0Rr1rm3SNtEM4RUe1bII-2-8Zer69eVrep-vN3Wp5vU4V5VSkjEiKK6qYFKCh5hh0UciKqfhKQoSsVc7youBVxTNOJBEZB0GExgSIyHM6Q5ejt_PuY9ChL7du8DaeLElGYhJELiJ1NVLKuxC8rsvOm1b6XYmh_G4wprryp8HIXuyNw2urqz_yt7IILEbg0zR697-pfNg8jsovhhJ6MQ</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Bindakhil, Mohammed</creator><creator>Akintoye, Sunday</creator><creator>Corby, Patricia</creator><creator>Stoopler, Eric T.</creator><creator>Greenberg, Martin S.</creator><creator>Shanti, Rabie</creator><creator>Tanaka, Takako I.</creator><creator>Sollecito, Thomas P.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0001-8432-3111</orcidid></search><sort><creationdate>202202</creationdate><title>Influence of topical corticosteroids on malignant transformation of oral lichen planus</title><author>Bindakhil, Mohammed ; Akintoye, Sunday ; Corby, Patricia ; Stoopler, Eric T. ; Greenberg, Martin S. ; Shanti, Rabie ; Tanaka, Takako I. ; Sollecito, Thomas P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-42a31d3c4a70e0f510e99ad4c99aa227afc848995dd5652a27650727e12027883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adrenal Cortex Hormones - adverse effects</topic><topic>Aged</topic><topic>Alcohol use</topic><topic>Candida</topic><topic>Carcinogenesis</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Cell Transformation, Neoplastic</topic><topic>Corticosteroids</topic><topic>Electronic medical records</topic><topic>Female</topic><topic>Gender</topic><topic>Head and Neck Neoplasms</topic><topic>Humans</topic><topic>Lichen planus</topic><topic>Lichen Planus, Oral - drug therapy</topic><topic>Male</topic><topic>malignant transformation</topic><topic>Mouth Neoplasms - drug therapy</topic><topic>Oral cancer</topic><topic>Oral carcinoma</topic><topic>oral lichen planus</topic><topic>Oral squamous cell carcinoma</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Smoking</topic><topic>Squamous cell carcinoma</topic><topic>Statistical analysis</topic><topic>Steroids</topic><topic>topical corticosteroids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bindakhil, Mohammed</creatorcontrib><creatorcontrib>Akintoye, Sunday</creatorcontrib><creatorcontrib>Corby, Patricia</creatorcontrib><creatorcontrib>Stoopler, Eric T.</creatorcontrib><creatorcontrib>Greenberg, Martin S.</creatorcontrib><creatorcontrib>Shanti, Rabie</creatorcontrib><creatorcontrib>Tanaka, Takako I.</creatorcontrib><creatorcontrib>Sollecito, Thomas P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bindakhil, Mohammed</au><au>Akintoye, Sunday</au><au>Corby, Patricia</au><au>Stoopler, Eric T.</au><au>Greenberg, Martin S.</au><au>Shanti, Rabie</au><au>Tanaka, Takako I.</au><au>Sollecito, Thomas P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of topical corticosteroids on malignant transformation of oral lichen planus</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2022-02</date><risdate>2022</risdate><volume>51</volume><issue>2</issue><spage>188</spage><epage>193</epage><pages>188-193</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Background
Oral lichen planus (OLP) is considered an oral potentially malignant disorder. While OLP has been associated with the development of oral squamous cell carcinoma (OSCC), little is known about the role of topical corticosteroids therapy (TCT) in the promotion of carcinogenesis. The study aimed to determine if TCT influences the time of malignant transformation of OLP to OSCC. The study also investigates this correlation in the presence or absence of Candida overgrowth, and in the context of conventional OSCC risk factors such as smoking, alcohol use, and male gender.
Methods
A retrospective analysis of electronic health records at a tertiary care academic medical center was performed. Patients with OLP and OSCC were considered for inclusion. The diagnosis of OLP required both clinical and histological documentation.
Results
Eighty‐two patients met inclusion criteria, consisting of 48 women (58.25%) and 34 men (41.5%) and the mean patient age was 65.9 years (SD = 13.25). Forty‐five patients (54.9%) received TCT for OLP before they developed OSCC. The time between the OLP and OSCC diagnoses increased by four years in patients who received topical steroid therapy for OLP (p < 0.001) and decreased by three years (p = 0.010) in those with Candida overgrowth. Gender, smoking, and alcohol use did not have a statistically significant influence on the time between OLP and OSCC.
Conclusion
The management of OLP using TCT potentially delayed cancer development in our study. Conversely, it appears that Candida may play a role in the field cancerization of OLP patients.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34748663</pmid><doi>10.1111/jop.13257</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8432-3111</orcidid></addata></record> |
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| ispartof | Journal of oral pathology & medicine, 2022-02, Vol.51 (2), p.188-193 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adrenal Cortex Hormones - adverse effects Aged Alcohol use Candida Carcinogenesis Carcinoma, Squamous Cell - drug therapy Cell Transformation, Neoplastic Corticosteroids Electronic medical records Female Gender Head and Neck Neoplasms Humans Lichen planus Lichen Planus, Oral - drug therapy Male malignant transformation Mouth Neoplasms - drug therapy Oral cancer Oral carcinoma oral lichen planus Oral squamous cell carcinoma Patients Retrospective Studies Risk factors Smoking Squamous cell carcinoma Statistical analysis Steroids topical corticosteroids |
| title | Influence of topical corticosteroids on malignant transformation of oral lichen planus |
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