Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA

Lipid nanoparticles (LNPs) are capable of delivering messenger ribonucleic acid (mRNA) efficiently and systemically as a result of both particle composition and architecture. The particle architecture is determined by how the various components interact with one another to establish a stable equilib...

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Veröffentlicht in:	Advanced functional materials 2022-02, Vol.32 (8), p.n/a
Hauptverfasser:	Cornebise, Mark, Narayanan, Elisabeth, Xia, Yan, Acosta, Edward, Ci, Lei, Koch, Hillary, Milton, Jaclyn, Sabnis, Staci, Salerno, Timothy, Benenato, Kerry E.
Format:	Artikel
Sprache:	eng
Schlagworte:	amino lipids Coalescing Hydrogen bonding lipid nanoparticles Lipids Materials science messenger ribonucleic acid delivery Molecular dynamics Nanoparticles Ribonucleic acid RNA squaramides
Online-Zugang:	Volltext
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