Synthesis of cyclodextrin-derived star poly(N-vinylpyrrolidone)/poly(lactic-co-glycolide) supramolecular micelles via host-guest interaction for delivery of doxorubicin
Supramolecular micelles are of particular interest in cancer therapy, owing to their capability to enable the on-demand drug release in tumor microenvironments. Nano platforms of supramolecular micelles can be facilely achieved from β-cyclodextrin (β-CD) based polymers. Herein, we developed novel su...
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| Veröffentlicht in: | Polymer (Guilford) 2021-02, Vol.214, p.123243, Article 123243 |
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| creator | Ramesh, Kalyan Balavigneswaran, Chelladurai Karthikeyan Siboro, Sonita A.P. Muthuvijayan, Vignesh Lim, Kwon Taek |
| description | Supramolecular micelles are of particular interest in cancer therapy, owing to their capability to enable the on-demand drug release in tumor microenvironments. Nano platforms of supramolecular micelles can be facilely achieved from β-cyclodextrin (β-CD) based polymers. Herein, we developed novel supramolecular micelles of β-CD-(PNVP)4-AD-PLGA produced from β-CD-grafted star poly(N-vinylpyrrolidone) (β-CD-(PNVP)4) and adamantine-terminated linear-poly(lactic-co-glycolide) (AD-PLGA) by host-guest interaction between β-cyclodextrin and adamantine groups. A model anticancer drug, doxorubicin (DOX) was loaded into the supramolecular micelles during self-assembly in aqueous solution. The dissociation of the supramolecular micelles was triggered by acidic environments, which led to the release of DOX more in pH 6.4 compared to pH 7.4. The in vitro toxicity of the drug loaded micelles revealed 87% of cytotoxicity after 72 h against glioblastoma (C6 cells) while β-CD-(PNVP)4-AD-PLGA was biocompatible to HEK 293 cells (non-cancerous). Furthermore, β-CD-(PNVP)4-AD-PLGA and β-CD-(PNVP)4-AD-PLGA/DOX were found to be hemocompatible and more suitable for Intravenous administration. Our results suggest that the developed micelle system can provide a promising robust and sustained anticancer drug delivery system for the future cancer treatment.
[Display omitted]
•Successful synthesis of novel supramolecular micelles of β-CD-(PNVP)4-AD-PLGA via host-guest interaction.•The dissociation of the supramolecular micelles triggered by acidic environment caused more DOX release.•Hemolysis studies revealed that the drug-loaded micelles were hemocompatible and safe for intravenous administration. |
| doi_str_mv | 10.1016/j.polymer.2020.123243 |
| format | Article |
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[Display omitted]
•Successful synthesis of novel supramolecular micelles of β-CD-(PNVP)4-AD-PLGA via host-guest interaction.•The dissociation of the supramolecular micelles triggered by acidic environment caused more DOX release.•Hemolysis studies revealed that the drug-loaded micelles were hemocompatible and safe for intravenous administration.</description><identifier>ISSN: 0032-3861</identifier><identifier>EISSN: 1873-2291</identifier><identifier>DOI: 10.1016/j.polymer.2020.123243</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Aqueous solutions ; Biocompatibility ; Cancer ; Cyclodextrins ; Cytotoxicity ; Doxorubicin ; Drug delivery ; Drug delivery systems ; Glioblastoma ; Host-guest inclusion complex ; Intravenous administration ; Micelles ; Microenvironments ; pH effects ; Polylactide-co-glycolide ; Polymers ; Polyvinylpyrrolidone ; RAFT polymerization ; Self-assembly ; Toxicity ; Vinylpyrrolidone ; β-Cyclodextrin</subject><ispartof>Polymer (Guilford), 2021-02, Vol.214, p.123243, Article 123243</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright Elsevier BV Feb 1, 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-9b2d2328e75099a97955edf57e65c7ee6b1bbc71c066657d65d77158e7f96d13</citedby><cites>FETCH-LOGICAL-c337t-9b2d2328e75099a97955edf57e65c7ee6b1bbc71c066657d65d77158e7f96d13</cites><orcidid>0000-0003-4921-9073 ; 0000-0002-9715-0034</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0032386120310685$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids></links><search><creatorcontrib>Ramesh, Kalyan</creatorcontrib><creatorcontrib>Balavigneswaran, Chelladurai Karthikeyan</creatorcontrib><creatorcontrib>Siboro, Sonita A.P.</creatorcontrib><creatorcontrib>Muthuvijayan, Vignesh</creatorcontrib><creatorcontrib>Lim, Kwon Taek</creatorcontrib><title>Synthesis of cyclodextrin-derived star poly(N-vinylpyrrolidone)/poly(lactic-co-glycolide) supramolecular micelles via host-guest interaction for delivery of doxorubicin</title><title>Polymer (Guilford)</title><description>Supramolecular micelles are of particular interest in cancer therapy, owing to their capability to enable the on-demand drug release in tumor microenvironments. Nano platforms of supramolecular micelles can be facilely achieved from β-cyclodextrin (β-CD) based polymers. Herein, we developed novel supramolecular micelles of β-CD-(PNVP)4-AD-PLGA produced from β-CD-grafted star poly(N-vinylpyrrolidone) (β-CD-(PNVP)4) and adamantine-terminated linear-poly(lactic-co-glycolide) (AD-PLGA) by host-guest interaction between β-cyclodextrin and adamantine groups. A model anticancer drug, doxorubicin (DOX) was loaded into the supramolecular micelles during self-assembly in aqueous solution. The dissociation of the supramolecular micelles was triggered by acidic environments, which led to the release of DOX more in pH 6.4 compared to pH 7.4. The in vitro toxicity of the drug loaded micelles revealed 87% of cytotoxicity after 72 h against glioblastoma (C6 cells) while β-CD-(PNVP)4-AD-PLGA was biocompatible to HEK 293 cells (non-cancerous). Furthermore, β-CD-(PNVP)4-AD-PLGA and β-CD-(PNVP)4-AD-PLGA/DOX were found to be hemocompatible and more suitable for Intravenous administration. Our results suggest that the developed micelle system can provide a promising robust and sustained anticancer drug delivery system for the future cancer treatment.
[Display omitted]
•Successful synthesis of novel supramolecular micelles of β-CD-(PNVP)4-AD-PLGA via host-guest interaction.•The dissociation of the supramolecular micelles triggered by acidic environment caused more DOX release.•Hemolysis studies revealed that the drug-loaded micelles were hemocompatible and safe for intravenous administration.</description><subject>Aqueous solutions</subject><subject>Biocompatibility</subject><subject>Cancer</subject><subject>Cyclodextrins</subject><subject>Cytotoxicity</subject><subject>Doxorubicin</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Glioblastoma</subject><subject>Host-guest inclusion complex</subject><subject>Intravenous administration</subject><subject>Micelles</subject><subject>Microenvironments</subject><subject>pH effects</subject><subject>Polylactide-co-glycolide</subject><subject>Polymers</subject><subject>Polyvinylpyrrolidone</subject><subject>RAFT polymerization</subject><subject>Self-assembly</subject><subject>Toxicity</subject><subject>Vinylpyrrolidone</subject><subject>β-Cyclodextrin</subject><issn>0032-3861</issn><issn>1873-2291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFUclqHDEQFSGBTBx_QkCQS3zQWIslTZ9CMM4CJj7Yd9EtVdsaNFJHUg_uP_JnRp3xPaeCelsVD6FPjG4ZZepyv51SWA6Qt5zytuOCX4k3aMN2WhDOO_YWbSgVnIidYu_Rh1L2lFIu-dUGvdwvsT5B8QWnEdvFhuTguWYfiYPsj-BwqX3Ga8KX3-To4xKmJecUvEsRLi7_AaG31VtiE3kMi10xuMBlnnJ_SAHsHJrDwVsIAQo--h4_pVLJ4wylYh8r5FWfIh5Txg5Ci83Leo9LzynPg7c-fkTvxj4UOH-dZ-jh-83D9U9ye_fj1_W3W2KF0JV0A3ft_x1oSbuu73QnJbhRalDSagA1sGGwmlmqlJLaKem0ZrLxx045Js7Q55PtlNOf9T6zT3OOLdFwxXdcc6FkY8kTy-ZUSobRTNkf-rwYRs3aidmb107M2ok5ddJ0X086aB8cfUOL9RAtOJ_BVuOS_4_DX83AnTA</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Ramesh, Kalyan</creator><creator>Balavigneswaran, Chelladurai Karthikeyan</creator><creator>Siboro, Sonita A.P.</creator><creator>Muthuvijayan, Vignesh</creator><creator>Lim, Kwon Taek</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-4921-9073</orcidid><orcidid>https://orcid.org/0000-0002-9715-0034</orcidid></search><sort><creationdate>20210201</creationdate><title>Synthesis of cyclodextrin-derived star poly(N-vinylpyrrolidone)/poly(lactic-co-glycolide) supramolecular micelles via host-guest interaction for delivery of doxorubicin</title><author>Ramesh, Kalyan ; Balavigneswaran, Chelladurai Karthikeyan ; Siboro, Sonita A.P. ; Muthuvijayan, Vignesh ; Lim, Kwon Taek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-9b2d2328e75099a97955edf57e65c7ee6b1bbc71c066657d65d77158e7f96d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aqueous solutions</topic><topic>Biocompatibility</topic><topic>Cancer</topic><topic>Cyclodextrins</topic><topic>Cytotoxicity</topic><topic>Doxorubicin</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Glioblastoma</topic><topic>Host-guest inclusion complex</topic><topic>Intravenous administration</topic><topic>Micelles</topic><topic>Microenvironments</topic><topic>pH effects</topic><topic>Polylactide-co-glycolide</topic><topic>Polymers</topic><topic>Polyvinylpyrrolidone</topic><topic>RAFT polymerization</topic><topic>Self-assembly</topic><topic>Toxicity</topic><topic>Vinylpyrrolidone</topic><topic>β-Cyclodextrin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramesh, Kalyan</creatorcontrib><creatorcontrib>Balavigneswaran, Chelladurai Karthikeyan</creatorcontrib><creatorcontrib>Siboro, Sonita A.P.</creatorcontrib><creatorcontrib>Muthuvijayan, Vignesh</creatorcontrib><creatorcontrib>Lim, Kwon Taek</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Polymer (Guilford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramesh, Kalyan</au><au>Balavigneswaran, Chelladurai Karthikeyan</au><au>Siboro, Sonita A.P.</au><au>Muthuvijayan, Vignesh</au><au>Lim, Kwon Taek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of cyclodextrin-derived star poly(N-vinylpyrrolidone)/poly(lactic-co-glycolide) supramolecular micelles via host-guest interaction for delivery of doxorubicin</atitle><jtitle>Polymer (Guilford)</jtitle><date>2021-02-01</date><risdate>2021</risdate><volume>214</volume><spage>123243</spage><pages>123243-</pages><artnum>123243</artnum><issn>0032-3861</issn><eissn>1873-2291</eissn><abstract>Supramolecular micelles are of particular interest in cancer therapy, owing to their capability to enable the on-demand drug release in tumor microenvironments. Nano platforms of supramolecular micelles can be facilely achieved from β-cyclodextrin (β-CD) based polymers. Herein, we developed novel supramolecular micelles of β-CD-(PNVP)4-AD-PLGA produced from β-CD-grafted star poly(N-vinylpyrrolidone) (β-CD-(PNVP)4) and adamantine-terminated linear-poly(lactic-co-glycolide) (AD-PLGA) by host-guest interaction between β-cyclodextrin and adamantine groups. A model anticancer drug, doxorubicin (DOX) was loaded into the supramolecular micelles during self-assembly in aqueous solution. The dissociation of the supramolecular micelles was triggered by acidic environments, which led to the release of DOX more in pH 6.4 compared to pH 7.4. The in vitro toxicity of the drug loaded micelles revealed 87% of cytotoxicity after 72 h against glioblastoma (C6 cells) while β-CD-(PNVP)4-AD-PLGA was biocompatible to HEK 293 cells (non-cancerous). Furthermore, β-CD-(PNVP)4-AD-PLGA and β-CD-(PNVP)4-AD-PLGA/DOX were found to be hemocompatible and more suitable for Intravenous administration. Our results suggest that the developed micelle system can provide a promising robust and sustained anticancer drug delivery system for the future cancer treatment.
[Display omitted]
•Successful synthesis of novel supramolecular micelles of β-CD-(PNVP)4-AD-PLGA via host-guest interaction.•The dissociation of the supramolecular micelles triggered by acidic environment caused more DOX release.•Hemolysis studies revealed that the drug-loaded micelles were hemocompatible and safe for intravenous administration.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.polymer.2020.123243</doi><orcidid>https://orcid.org/0000-0003-4921-9073</orcidid><orcidid>https://orcid.org/0000-0002-9715-0034</orcidid></addata></record> |
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| ispartof | Polymer (Guilford), 2021-02, Vol.214, p.123243, Article 123243 |
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| source | Elsevier ScienceDirect Journals |
| subjects | Aqueous solutions Biocompatibility Cancer Cyclodextrins Cytotoxicity Doxorubicin Drug delivery Drug delivery systems Glioblastoma Host-guest inclusion complex Intravenous administration Micelles Microenvironments pH effects Polylactide-co-glycolide Polymers Polyvinylpyrrolidone RAFT polymerization Self-assembly Toxicity Vinylpyrrolidone β-Cyclodextrin |
| title | Synthesis of cyclodextrin-derived star poly(N-vinylpyrrolidone)/poly(lactic-co-glycolide) supramolecular micelles via host-guest interaction for delivery of doxorubicin |
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