Diketopyrrolopyrrole-based sensor for over-expressed peroxynitrite in drug-induced hepatotoxicity via ratiometric fluorescence imaging

Early diagnosis and detection of drug-induced liver injury (DILI) is great significance for the effective prevention and treatment of patients with liver injury. Studies indicate that the up-regulation of peroxynitrite (ONOO−) levels in liver is profoundly involved in acetaminophen (APAP)-induced li...

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Veröffentlicht in:	Sensors and actuators. B, Chemical Chemical, 2022-02, Vol.352, p.130992, Article 130992
Hauptverfasser:	Wang, Nannan, Wang, Han, Zhang, Jian, Ji, Xin, Su, Huihui, Liu, Jinying, Wang, Jiamin, Zhao, Weili
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Bioimaging Cytoplasm Diagnosis Drug-induced liver injury Fluorescent indicators Fluorescent probe Glutathione Injury prevention Liver Lysosomes Medical imaging Mitochondria Organelles Pathogenesis Peroxynitrite Signal to noise ratio Subcellular localization
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