Investigation of the biological activity of benzylpenicillin sodium salt under the influence of pulsed magnetic field

An increase in the diameters of the zones of growth inhibition of Escherichia coli M-17 compared with the control (not treated with PMF) was shown when the benzylpenicillin powder was exposed to a pulsed magnetic field, which means an increase in antibacterial activity. In addition, exposure of benzylpenicillin to PMF did not induce free radical formation and did not alter acute toxicity. The appearance of free radicals in irradiated preparations was assessed by the method of electron paramagnetic resonance (EPR). Acute toxicity was studied by intraperitoneal administration of antibiotics to mice before and after exposure to a pulsed electromagnetic field with the calculation and comparison of LD50 values.