Jararhagin-C, a disintegrin-like protein, improves wound healing in mice through stimulation of M2-like macrophage, angiogenesis and collagen deposition

•Intradermal administration of Jar-C holds a potential therapeutic application in wound healing.•Jararhagin-C inhibits neutrofilic inflammation and pro-inflammatory cytokines production in excisional wounds.•Results highlight the effects of Jar-C promoting M2-macrophage polarization, angiogenesis an...

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Veröffentlicht in:	International immunopharmacology 2021-12, Vol.101 (Pt B), p.108224, Article 108224
Hauptverfasser:	Ferreira, Bruno Antonio, De Moura, Francyelle Borges Rosa, Tomiosso, Tatiana Carla, Corrêa, Natássia Caroline Resende, Goulart, Luiz Ricardo, Barcelos, Lucíola Silva, Clissa, Patrícia Bianca, Araújo, Fernanda de Assis
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Blood vessels Bothrops jararaca Venom Cell Survival - drug effects Collagen Collagen - metabolism Crotalid Venoms - chemistry Cytokines Cytokines - genetics Cytokines - metabolism Deposition Disintegrin Disintegrins - chemistry Disintegrins - pharmacology Fibroblast growth factors Fibrogenesis Gene expression Gene Expression Regulation - drug effects Human Umbilical Vein Endothelial Cells Humans Inflammation Leukocytes (neutrophilic) Leukocytes - drug effects Leukocytes - physiology Macrophage polarization Macrophages Mice Monocyte chemoattractant protein 1 Neovascularization, Physiologic - drug effects Phenotypes Pro-angiogenic Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Stimulation Transforming growth factor-b1 Tumor necrosis factor Vascular endothelial growth factor Venom Wound healing Wound Healing - drug effects
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