Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative

Pain is responsible for inducing physical and mental stress, interfering negatively in patients' quality of life. Classic analgesic drugs, such as opioids and non‐steroidal anti‐inflammatory drugs, are known for their wide range of adverse effects, making it important to develop new drugs. Thus...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2022-03, Vol.49 (3), p.419-431
Hauptverfasser:	Gonçalves, Gabriela Mastrangelo, Oliveira, Joyce Mattos de, Fernandes, Thayane Ferreira da Costa, de Carvalho Cid, Gabriela, Laureano‐Melo, Roberto, Côrtes, Wellington da Silva, Carvalho, Vivian de Assunção Nogueira, Capim, Saulo Luis, Vasconcellos, Mário Luiz Araujo de Almeida, Marinho, Bruno Guimarães
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Analgesics Analgesics - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology antihyperalgesic effect Capsaicin Capsaicin - toxicity Capsaicin receptors Cyclic GMP cytokines Drugs Formaldehyde Gene Expression Regulation - drug effects Glibenclamide Glutamic Acid - toxicity Hot Temperature - adverse effects Humans hybrids NSAID's tetrahydropyran derivative Inflammation Intoxication Male Mice Naloxone Naltrindole Naphthalene Narcotics NO/cGMP/K+ ATP pathway Nonsteroidal anti-inflammatory drugs opioid system Pain Pain - chemically induced Pain - drug therapy Pain perception Prostaglandin E2 Psychological stress Pyrans - chemistry Pyrans - pharmacology Quality of life Stimulation Tumor necrosis factor
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