Inhibition of Ras protein activator like 2 produces antitumor effects in gastric cancer via the suppression of YAP1 activation

Ras protein activator like 2 (RASAL2) has a cancer‐related function, but plays inconsistent roles in different malignancies. This project was designed to determine the role of RASAL2 in carcinogenesis in gastric cancer. The Cancer Genome Atlas data revealed high levels of RASAL2 in gastric cancer ti...

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Veröffentlicht in:	Environmental toxicology 2022-03, Vol.37 (3), p.527-538
Hauptverfasser:	Hu, Yuan, Zhang, Pengchuang, Shi, Yu, Dong, Xuyuan, Wu, Yinying, Dong, Danfeng, Li, Enxiao, Fan, Yangwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer properties Antitumor activity Antitumour agents Cancer Carcinogenesis Carcinogens Cell Line, Tumor Cell lines Cells Cisplatin Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genomes GTPase-Activating Proteins Humans Mesenchyme Mice Mice, Nude Neoplasms Nucleotide sequence PCR Proliferation Proteins Ras protein ras Proteins RASAL2 Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Survival Tumor cell lines Tumors Western blotting Xenografts Xenotransplantation YAP-Signaling Proteins YAP1 Yes-associated protein
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