Anhedonia in Depression: Neurobiological and Genetic Aspects
Anhedonia is a pathogenetically important clinical phenotype and a potential endophenotype for depressive symptoms with very high contributions from biological and genetic factors. The neurobiological mechanisms of anhedonia consist of impairments to the functioning of the brain “reward” system, whi...
Gespeichert in:
| Veröffentlicht in: | Neuroscience and behavioral physiology 2022, Vol.52 (1), p.30-38 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 38 |
|---|---|
| container_issue | 1 |
| container_start_page | 30 |
| container_title | Neuroscience and behavioral physiology |
| container_volume | 52 |
| creator | Kibitov, A. O. Mazo, G. E. |
| description | Anhedonia is a pathogenetically important clinical phenotype and a potential endophenotype for depressive symptoms with very high contributions from biological and genetic factors. The neurobiological mechanisms of anhedonia consist of impairments to the functioning of the brain “reward” system, which has been confirmed by a significant number of neuroimaging, genetic, and experimental studies. Anhedonia is transnosological in nature and is a complex phenomenon; its correct assessment in the context of one or another investigation paradigm is important. The optimum approach is to form a set of mutually supplementing investigation strategies assessing the most important facets of anhedonia, regardless of the relationship with the nosological form of the illness, in the framework of a single study using various methods to seek appropriate biomarkers for the severity of anhedonia (genetic, neuroimaging, biochemical). High-quality organization of studies of this type based on correct evidence-based medicine methodology should produce valuable systems of biomarkers in the near future, which when validated on independent cohorts will be useful for personalizing the diagnosis and treatment of depression. |
| doi_str_mv | 10.1007/s11055-022-01204-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2623629468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2623629468</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2348-871b777abaaea75d632728ef00bb15b73af2b32011b8c7a8f60bfb49c8a461773</originalsourceid><addsrcrecordid>eNp9kDFPwzAQRi0EEqXwB5giMRvOdpJzEEtVoCBVsIDEZtmuU1wVO9jpwL8nJUhsTLe89530CDlncMkA8CozBlVFgXMKjENJ5QGZsAoFlU3zdkgmAA1SqMrmmJzkvIFBQgkTcjML724Vg9eFD8Wt65LL2cdwXTy5XYrGx21ce6u3hQ6rYuGC670tZrlzts-n5KjV2-zOfu-UvN7fvcwf6PJ58TifLanlopRUIjOIqI3WTmO1qgVHLl0LYAyrDArdciM4MGakRS3bGkxrysZKXdYMUUzJxbjbpfi5c7lXm7hLYXipeM1FzZuylgPFR8qmmHNyreqS_9DpSzFQ-0pqrKSGSuqnktpLYpTyAIe1S3_T_1jfmMFpJw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2623629468</pqid></control><display><type>article</type><title>Anhedonia in Depression: Neurobiological and Genetic Aspects</title><source>SpringerLink Journals - AutoHoldings</source><creator>Kibitov, A. O. ; Mazo, G. E.</creator><creatorcontrib>Kibitov, A. O. ; Mazo, G. E.</creatorcontrib><description>Anhedonia is a pathogenetically important clinical phenotype and a potential endophenotype for depressive symptoms with very high contributions from biological and genetic factors. The neurobiological mechanisms of anhedonia consist of impairments to the functioning of the brain “reward” system, which has been confirmed by a significant number of neuroimaging, genetic, and experimental studies. Anhedonia is transnosological in nature and is a complex phenomenon; its correct assessment in the context of one or another investigation paradigm is important. The optimum approach is to form a set of mutually supplementing investigation strategies assessing the most important facets of anhedonia, regardless of the relationship with the nosological form of the illness, in the framework of a single study using various methods to seek appropriate biomarkers for the severity of anhedonia (genetic, neuroimaging, biochemical). High-quality organization of studies of this type based on correct evidence-based medicine methodology should produce valuable systems of biomarkers in the near future, which when validated on independent cohorts will be useful for personalizing the diagnosis and treatment of depression.</description><identifier>ISSN: 0097-0549</identifier><identifier>EISSN: 1573-899X</identifier><identifier>DOI: 10.1007/s11055-022-01204-8</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Behavioral Sciences ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Genetic factors ; Hedonic response ; Medical imaging ; Mental depression ; Neurobiology ; Neuroimaging ; Neurosciences ; Phenotypes ; Reinforcement</subject><ispartof>Neuroscience and behavioral physiology, 2022, Vol.52 (1), p.30-38</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2348-871b777abaaea75d632728ef00bb15b73af2b32011b8c7a8f60bfb49c8a461773</citedby><cites>FETCH-LOGICAL-c2348-871b777abaaea75d632728ef00bb15b73af2b32011b8c7a8f60bfb49c8a461773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11055-022-01204-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11055-022-01204-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Kibitov, A. O.</creatorcontrib><creatorcontrib>Mazo, G. E.</creatorcontrib><title>Anhedonia in Depression: Neurobiological and Genetic Aspects</title><title>Neuroscience and behavioral physiology</title><addtitle>Neurosci Behav Physi</addtitle><description>Anhedonia is a pathogenetically important clinical phenotype and a potential endophenotype for depressive symptoms with very high contributions from biological and genetic factors. The neurobiological mechanisms of anhedonia consist of impairments to the functioning of the brain “reward” system, which has been confirmed by a significant number of neuroimaging, genetic, and experimental studies. Anhedonia is transnosological in nature and is a complex phenomenon; its correct assessment in the context of one or another investigation paradigm is important. The optimum approach is to form a set of mutually supplementing investigation strategies assessing the most important facets of anhedonia, regardless of the relationship with the nosological form of the illness, in the framework of a single study using various methods to seek appropriate biomarkers for the severity of anhedonia (genetic, neuroimaging, biochemical). High-quality organization of studies of this type based on correct evidence-based medicine methodology should produce valuable systems of biomarkers in the near future, which when validated on independent cohorts will be useful for personalizing the diagnosis and treatment of depression.</description><subject>Behavioral Sciences</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Genetic factors</subject><subject>Hedonic response</subject><subject>Medical imaging</subject><subject>Mental depression</subject><subject>Neurobiology</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Phenotypes</subject><subject>Reinforcement</subject><issn>0097-0549</issn><issn>1573-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kDFPwzAQRi0EEqXwB5giMRvOdpJzEEtVoCBVsIDEZtmuU1wVO9jpwL8nJUhsTLe89530CDlncMkA8CozBlVFgXMKjENJ5QGZsAoFlU3zdkgmAA1SqMrmmJzkvIFBQgkTcjML724Vg9eFD8Wt65LL2cdwXTy5XYrGx21ce6u3hQ6rYuGC670tZrlzts-n5KjV2-zOfu-UvN7fvcwf6PJ58TifLanlopRUIjOIqI3WTmO1qgVHLl0LYAyrDArdciM4MGakRS3bGkxrysZKXdYMUUzJxbjbpfi5c7lXm7hLYXipeM1FzZuylgPFR8qmmHNyreqS_9DpSzFQ-0pqrKSGSuqnktpLYpTyAIe1S3_T_1jfmMFpJw</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Kibitov, A. O.</creator><creator>Mazo, G. E.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>2022</creationdate><title>Anhedonia in Depression: Neurobiological and Genetic Aspects</title><author>Kibitov, A. O. ; Mazo, G. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2348-871b777abaaea75d632728ef00bb15b73af2b32011b8c7a8f60bfb49c8a461773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Behavioral Sciences</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Genetic factors</topic><topic>Hedonic response</topic><topic>Medical imaging</topic><topic>Mental depression</topic><topic>Neurobiology</topic><topic>Neuroimaging</topic><topic>Neurosciences</topic><topic>Phenotypes</topic><topic>Reinforcement</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kibitov, A. O.</creatorcontrib><creatorcontrib>Mazo, G. E.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Neuroscience and behavioral physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kibitov, A. O.</au><au>Mazo, G. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anhedonia in Depression: Neurobiological and Genetic Aspects</atitle><jtitle>Neuroscience and behavioral physiology</jtitle><stitle>Neurosci Behav Physi</stitle><date>2022</date><risdate>2022</risdate><volume>52</volume><issue>1</issue><spage>30</spage><epage>38</epage><pages>30-38</pages><issn>0097-0549</issn><eissn>1573-899X</eissn><abstract>Anhedonia is a pathogenetically important clinical phenotype and a potential endophenotype for depressive symptoms with very high contributions from biological and genetic factors. The neurobiological mechanisms of anhedonia consist of impairments to the functioning of the brain “reward” system, which has been confirmed by a significant number of neuroimaging, genetic, and experimental studies. Anhedonia is transnosological in nature and is a complex phenomenon; its correct assessment in the context of one or another investigation paradigm is important. The optimum approach is to form a set of mutually supplementing investigation strategies assessing the most important facets of anhedonia, regardless of the relationship with the nosological form of the illness, in the framework of a single study using various methods to seek appropriate biomarkers for the severity of anhedonia (genetic, neuroimaging, biochemical). High-quality organization of studies of this type based on correct evidence-based medicine methodology should produce valuable systems of biomarkers in the near future, which when validated on independent cohorts will be useful for personalizing the diagnosis and treatment of depression.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11055-022-01204-8</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0097-0549 |
| ispartof | Neuroscience and behavioral physiology, 2022, Vol.52 (1), p.30-38 |
| issn | 0097-0549 1573-899X |
| language | eng |
| recordid | cdi_proquest_journals_2623629468 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Behavioral Sciences Biomarkers Biomedical and Life Sciences Biomedicine Genetic factors Hedonic response Medical imaging Mental depression Neurobiology Neuroimaging Neurosciences Phenotypes Reinforcement |
| title | Anhedonia in Depression: Neurobiological and Genetic Aspects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T07%3A43%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anhedonia%20in%20Depression:%20Neurobiological%20and%20Genetic%20Aspects&rft.jtitle=Neuroscience%20and%20behavioral%20physiology&rft.au=Kibitov,%20A.%20O.&rft.date=2022&rft.volume=52&rft.issue=1&rft.spage=30&rft.epage=38&rft.pages=30-38&rft.issn=0097-0549&rft.eissn=1573-899X&rft_id=info:doi/10.1007/s11055-022-01204-8&rft_dat=%3Cproquest_cross%3E2623629468%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2623629468&rft_id=info:pmid/&rfr_iscdi=true |