Solubility and thermodynamic analysis of vinpocetine in various mono solvents at different temperatures
In the present study, the solubility of vinpocetine in ten commonly used solvents at different temperatures range of T = 298.2–323.2 K was examined and correlate the solubility data with Apelblat and Van’t Hoff models and lastly the dissolution thermodynamic parameters of vinpocetine in each solven...
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| Veröffentlicht in: | Journal of thermal analysis and calorimetry 2022-02, Vol.147 (4), p.3117-3126 |
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| container_title | Journal of thermal analysis and calorimetry |
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| creator | Ahad, Abdul Shakeel, Faiyaz Raish, Mohammad Ahmad, Ajaz Bin Jardan, Yousef A. Al-Jenoobi, Fahad I. Al-Mohizea, Abdullah M. |
| description | In the present study, the solubility of vinpocetine in ten commonly used solvents at different temperatures range of
T
= 298.2–323.2 K was examined and correlate the solubility data with Apelblat and Van’t Hoff models and lastly the dissolution thermodynamic parameters of vinpocetine in each solvent were estimated. It was observed that the vinpocetine solubility found less in water and determined to be better in non-polar solvents. Both (Apelblat and Van’t Hoff) models are found suitable to correlate the measured solubility data, still, the Van’t Hoff equation demonstrated to be more precise for the correlation of solubilities of VPN in investigated solvents. The maximum value of activity coefficients (
γ
2
) for vinpocetine was observed in water, this could be due to low solubility of vinpocetine in water, while the value of
γ
2
was observed lowest in Transcutol owing to maximum solubility of vinpocetine in Transcutol. The conclusions of thermodynamic parameters analysis of vinpocetine in various studied solvents brought out that the vinpocetine solubilization process was endothermic, non-spontaneous and entropy-driven. The outcomes of the present study would provide enormous support in vinpocetine solubilization, pre-formulation and dosage form development in pharmaceuticals. |
| doi_str_mv | 10.1007/s10973-021-10757-8 |
| format | Article |
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T
= 298.2–323.2 K was examined and correlate the solubility data with Apelblat and Van’t Hoff models and lastly the dissolution thermodynamic parameters of vinpocetine in each solvent were estimated. It was observed that the vinpocetine solubility found less in water and determined to be better in non-polar solvents. Both (Apelblat and Van’t Hoff) models are found suitable to correlate the measured solubility data, still, the Van’t Hoff equation demonstrated to be more precise for the correlation of solubilities of VPN in investigated solvents. The maximum value of activity coefficients (
γ
2
) for vinpocetine was observed in water, this could be due to low solubility of vinpocetine in water, while the value of
γ
2
was observed lowest in Transcutol owing to maximum solubility of vinpocetine in Transcutol. The conclusions of thermodynamic parameters analysis of vinpocetine in various studied solvents brought out that the vinpocetine solubilization process was endothermic, non-spontaneous and entropy-driven. The outcomes of the present study would provide enormous support in vinpocetine solubilization, pre-formulation and dosage form development in pharmaceuticals.</description><identifier>ISSN: 1388-6150</identifier><identifier>EISSN: 1588-2926</identifier><identifier>DOI: 10.1007/s10973-021-10757-8</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Activity coefficients ; Analysis ; Analytical Chemistry ; Chemistry ; Chemistry and Materials Science ; Endothermic reactions ; Inorganic Chemistry ; Mathematical models ; Measurement Science and Instrumentation ; Parameters ; Physical Chemistry ; Polymer Sciences ; Solubility ; Solubilization ; Solvents ; Thermodynamics ; Virtual private networks</subject><ispartof>Journal of thermal analysis and calorimetry, 2022-02, Vol.147 (4), p.3117-3126</ispartof><rights>Akadémiai Kiadó, Budapest, Hungary 2021</rights><rights>COPYRIGHT 2022 Springer</rights><rights>Akadémiai Kiadó, Budapest, Hungary 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-2a64e67f4552c8b51f6649deeaa1bbf3d8058408336ca9058ae8f550770061553</citedby><cites>FETCH-LOGICAL-c392t-2a64e67f4552c8b51f6649deeaa1bbf3d8058408336ca9058ae8f550770061553</cites><orcidid>0000-0002-8769-4564</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10973-021-10757-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10973-021-10757-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Ahad, Abdul</creatorcontrib><creatorcontrib>Shakeel, Faiyaz</creatorcontrib><creatorcontrib>Raish, Mohammad</creatorcontrib><creatorcontrib>Ahmad, Ajaz</creatorcontrib><creatorcontrib>Bin Jardan, Yousef A.</creatorcontrib><creatorcontrib>Al-Jenoobi, Fahad I.</creatorcontrib><creatorcontrib>Al-Mohizea, Abdullah M.</creatorcontrib><title>Solubility and thermodynamic analysis of vinpocetine in various mono solvents at different temperatures</title><title>Journal of thermal analysis and calorimetry</title><addtitle>J Therm Anal Calorim</addtitle><description>In the present study, the solubility of vinpocetine in ten commonly used solvents at different temperatures range of
T
= 298.2–323.2 K was examined and correlate the solubility data with Apelblat and Van’t Hoff models and lastly the dissolution thermodynamic parameters of vinpocetine in each solvent were estimated. It was observed that the vinpocetine solubility found less in water and determined to be better in non-polar solvents. Both (Apelblat and Van’t Hoff) models are found suitable to correlate the measured solubility data, still, the Van’t Hoff equation demonstrated to be more precise for the correlation of solubilities of VPN in investigated solvents. The maximum value of activity coefficients (
γ
2
) for vinpocetine was observed in water, this could be due to low solubility of vinpocetine in water, while the value of
γ
2
was observed lowest in Transcutol owing to maximum solubility of vinpocetine in Transcutol. The conclusions of thermodynamic parameters analysis of vinpocetine in various studied solvents brought out that the vinpocetine solubilization process was endothermic, non-spontaneous and entropy-driven. The outcomes of the present study would provide enormous support in vinpocetine solubilization, pre-formulation and dosage form development in pharmaceuticals.</description><subject>Activity coefficients</subject><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Endothermic reactions</subject><subject>Inorganic Chemistry</subject><subject>Mathematical models</subject><subject>Measurement Science and Instrumentation</subject><subject>Parameters</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Solubility</subject><subject>Solubilization</subject><subject>Solvents</subject><subject>Thermodynamics</subject><subject>Virtual private networks</subject><issn>1388-6150</issn><issn>1588-2926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kUFrHSEUhYfQQtIkfyAroasuJrnq6OgyhLYJBAJNuxbfzPXVMKOv6jz6_n1sJhCyKS48Xr4jHk_TXFC4pAD9Vaage94Coy2FXvStOmpOqFCqZZrJD1XzqiUVcNx8yvkJALQGetJsH-O0bPzky4HYMJLyG9Mcx0Owsx_qxE6H7DOJjux92MUBiw9IfCB7m3xcMpljiCTHaY-hZGILGb1zmOqJFJx3mGxZEuaz5qOzU8bz1_20-fXt68-b2_b-4fvdzfV9O3DNSsus7FD2rhOCDWojqJOy0yOitXSzcXxUIFQHinM5WF21ReWEgL4HqOkEP20-r_fuUvyzYC7mKS6pxsiGScYlCNp1lbpcqa2d0PjgYkl2qGvEGjsGdL7Or6WunwmM6Wr48s5QmYJ_y9YuOZu7xx_vWbayQ4o5J3Rml_xs08FQMP_aMmtbprZlXtoyqpr4asoVDltMb-_-j-sZ5TiX3g</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Ahad, Abdul</creator><creator>Shakeel, Faiyaz</creator><creator>Raish, Mohammad</creator><creator>Ahmad, Ajaz</creator><creator>Bin Jardan, Yousef A.</creator><creator>Al-Jenoobi, Fahad I.</creator><creator>Al-Mohizea, Abdullah M.</creator><general>Springer International Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><orcidid>https://orcid.org/0000-0002-8769-4564</orcidid></search><sort><creationdate>20220201</creationdate><title>Solubility and thermodynamic analysis of vinpocetine in various mono solvents at different temperatures</title><author>Ahad, Abdul ; Shakeel, Faiyaz ; Raish, Mohammad ; Ahmad, Ajaz ; Bin Jardan, Yousef A. ; Al-Jenoobi, Fahad I. ; Al-Mohizea, Abdullah M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-2a64e67f4552c8b51f6649deeaa1bbf3d8058408336ca9058ae8f550770061553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Activity coefficients</topic><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Endothermic reactions</topic><topic>Inorganic Chemistry</topic><topic>Mathematical models</topic><topic>Measurement Science and Instrumentation</topic><topic>Parameters</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Solubility</topic><topic>Solubilization</topic><topic>Solvents</topic><topic>Thermodynamics</topic><topic>Virtual private networks</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahad, Abdul</creatorcontrib><creatorcontrib>Shakeel, Faiyaz</creatorcontrib><creatorcontrib>Raish, Mohammad</creatorcontrib><creatorcontrib>Ahmad, Ajaz</creatorcontrib><creatorcontrib>Bin Jardan, Yousef A.</creatorcontrib><creatorcontrib>Al-Jenoobi, Fahad I.</creatorcontrib><creatorcontrib>Al-Mohizea, Abdullah M.</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Journal of thermal analysis and calorimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahad, Abdul</au><au>Shakeel, Faiyaz</au><au>Raish, Mohammad</au><au>Ahmad, Ajaz</au><au>Bin Jardan, Yousef A.</au><au>Al-Jenoobi, Fahad I.</au><au>Al-Mohizea, Abdullah M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solubility and thermodynamic analysis of vinpocetine in various mono solvents at different temperatures</atitle><jtitle>Journal of thermal analysis and calorimetry</jtitle><stitle>J Therm Anal Calorim</stitle><date>2022-02-01</date><risdate>2022</risdate><volume>147</volume><issue>4</issue><spage>3117</spage><epage>3126</epage><pages>3117-3126</pages><issn>1388-6150</issn><eissn>1588-2926</eissn><abstract>In the present study, the solubility of vinpocetine in ten commonly used solvents at different temperatures range of
T
= 298.2–323.2 K was examined and correlate the solubility data with Apelblat and Van’t Hoff models and lastly the dissolution thermodynamic parameters of vinpocetine in each solvent were estimated. It was observed that the vinpocetine solubility found less in water and determined to be better in non-polar solvents. Both (Apelblat and Van’t Hoff) models are found suitable to correlate the measured solubility data, still, the Van’t Hoff equation demonstrated to be more precise for the correlation of solubilities of VPN in investigated solvents. The maximum value of activity coefficients (
γ
2
) for vinpocetine was observed in water, this could be due to low solubility of vinpocetine in water, while the value of
γ
2
was observed lowest in Transcutol owing to maximum solubility of vinpocetine in Transcutol. The conclusions of thermodynamic parameters analysis of vinpocetine in various studied solvents brought out that the vinpocetine solubilization process was endothermic, non-spontaneous and entropy-driven. The outcomes of the present study would provide enormous support in vinpocetine solubilization, pre-formulation and dosage form development in pharmaceuticals.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s10973-021-10757-8</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8769-4564</orcidid></addata></record> |
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| subjects | Activity coefficients Analysis Analytical Chemistry Chemistry Chemistry and Materials Science Endothermic reactions Inorganic Chemistry Mathematical models Measurement Science and Instrumentation Parameters Physical Chemistry Polymer Sciences Solubility Solubilization Solvents Thermodynamics Virtual private networks |
| title | Solubility and thermodynamic analysis of vinpocetine in various mono solvents at different temperatures |
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