Fabrication and in vitro/in vivo characterization of Eudragit enteric nanoparticles loaded with indomethacin
The purpose of this study was to tailor and evaluate indomethacin-loaded Eudragit L 100–55 enteric nanoparticles (IDM@NPs). Nanoprecipitation approach was used to fabricate IDM@NPs, and the formulation was optimized by a central composite design (CCD). The physicochemical properties of IDM@NPs were...
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| Veröffentlicht in: | Chemical papers 2022-02, Vol.76 (2), p.1119-1133 |
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| creator | Wang, Xingrong Wang, Mufang Wang, Qi Yuan, Ye Hao, Qiulian Bi, Yanping He, Yujing Zhao, Jing Hao, Jifu |
| description | The purpose of this study was to tailor and evaluate indomethacin-loaded Eudragit L 100–55 enteric nanoparticles (IDM@NPs). Nanoprecipitation approach was used to fabricate IDM@NPs, and the formulation was optimized by a central composite design (CCD). The physicochemical properties of IDM@NPs were characterized by FTIR, XRD and DSC, respectively. Furthermore, in situ intestinal perfusion, in vivo pharmacokinetic analysis and pharmacodynamics experiments were performed. The obtained IDM@NPs were in spherical shape. The results of FITC, XRD and DSC indicated that no molecular interaction occurred and no crystal drug present in the nanoparticles. The in vitro release confirmed the pH-sensitive released profiles of IDM@NPs. The
C
max
and
AUC
of IDM@NPs were about 1.24-fold and 1.39-fold greater than those of given coarse IDM group. In addition, the therapeutic activity illustrated that IDM@NPs have the similar anti-inflammatory and analgesic effects as compared with IDM suspensions, while there were no statistical differences between the high- and low-dose group of IDM@NPs. The present study demonstrated the enteric nanoparticles could be used as potential therapeutic platforms for oral delivery of IDM. |
| doi_str_mv | 10.1007/s11696-021-01921-3 |
| format | Article |
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C
max
and
AUC
of IDM@NPs were about 1.24-fold and 1.39-fold greater than those of given coarse IDM group. In addition, the therapeutic activity illustrated that IDM@NPs have the similar anti-inflammatory and analgesic effects as compared with IDM suspensions, while there were no statistical differences between the high- and low-dose group of IDM@NPs. The present study demonstrated the enteric nanoparticles could be used as potential therapeutic platforms for oral delivery of IDM.</description><identifier>ISSN: 0366-6352</identifier><identifier>EISSN: 1336-9075</identifier><identifier>EISSN: 2585-7290</identifier><identifier>DOI: 10.1007/s11696-021-01921-3</identifier><language>eng</language><publisher>Warsaw: Versita</publisher><subject>Biochemistry ; Biotechnology ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Design optimization ; Industrial Chemistry/Chemical Engineering ; Materials Science ; Medicinal Chemistry ; Molecular interactions ; Nanoparticles ; Original Paper ; Pharmacology</subject><ispartof>Chemical papers, 2022-02, Vol.76 (2), p.1119-1133</ispartof><rights>Institute of Chemistry, Slovak Academy of Sciences 2021</rights><rights>Institute of Chemistry, Slovak Academy of Sciences 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-d68ebc0bf9a5260f0d4b7a0aff8735b65780c8ff36a4f8c00206c087a4279f6d3</citedby><cites>FETCH-LOGICAL-c319t-d68ebc0bf9a5260f0d4b7a0aff8735b65780c8ff36a4f8c00206c087a4279f6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11696-021-01921-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11696-021-01921-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Wang, Xingrong</creatorcontrib><creatorcontrib>Wang, Mufang</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Yuan, Ye</creatorcontrib><creatorcontrib>Hao, Qiulian</creatorcontrib><creatorcontrib>Bi, Yanping</creatorcontrib><creatorcontrib>He, Yujing</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><creatorcontrib>Hao, Jifu</creatorcontrib><title>Fabrication and in vitro/in vivo characterization of Eudragit enteric nanoparticles loaded with indomethacin</title><title>Chemical papers</title><addtitle>Chem. Pap</addtitle><description>The purpose of this study was to tailor and evaluate indomethacin-loaded Eudragit L 100–55 enteric nanoparticles (IDM@NPs). Nanoprecipitation approach was used to fabricate IDM@NPs, and the formulation was optimized by a central composite design (CCD). The physicochemical properties of IDM@NPs were characterized by FTIR, XRD and DSC, respectively. Furthermore, in situ intestinal perfusion, in vivo pharmacokinetic analysis and pharmacodynamics experiments were performed. The obtained IDM@NPs were in spherical shape. The results of FITC, XRD and DSC indicated that no molecular interaction occurred and no crystal drug present in the nanoparticles. The in vitro release confirmed the pH-sensitive released profiles of IDM@NPs. The
C
max
and
AUC
of IDM@NPs were about 1.24-fold and 1.39-fold greater than those of given coarse IDM group. In addition, the therapeutic activity illustrated that IDM@NPs have the similar anti-inflammatory and analgesic effects as compared with IDM suspensions, while there were no statistical differences between the high- and low-dose group of IDM@NPs. The present study demonstrated the enteric nanoparticles could be used as potential therapeutic platforms for oral delivery of IDM.</description><subject>Biochemistry</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Design optimization</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Materials Science</subject><subject>Medicinal Chemistry</subject><subject>Molecular interactions</subject><subject>Nanoparticles</subject><subject>Original Paper</subject><subject>Pharmacology</subject><issn>0366-6352</issn><issn>1336-9075</issn><issn>2585-7290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMFKAzEQhoMoWKsv4Cngee0k2c3uHkVaFQpe9Bxms0mb0iY1SSv69K6u4M3LZCDf_w98hFwzuGUA9SwxJltZAGcFsHaY4oRMmBCyaKGuTskEhJSFFBU_JxcpbQDKEiqYkO0Cu-g0Zhc8Rd9T5-nR5RhmP8sxUL3GiDqb6D5HKlg6P_QRVy5T478_NPXowx5jdnprEt0G7E1P311eD3192Jm8Ru38JTmzuE3m6vedktfF_OX-sVg-Pzzd3y0LLVibi142ptPQ2RYrLsFCX3Y1Alrb1KLqZFU3oBtrhcTSNhqAg9TQ1FjyurWyF1NyM_buY3g7mJTVJhyiH04qLrkoOW-qeqD4SOkYUorGqn10O4wfioH6tqpGq2qwqn6sKjGExBhKA-xXJv5V_5P6Am5bfEY</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Wang, Xingrong</creator><creator>Wang, Mufang</creator><creator>Wang, Qi</creator><creator>Yuan, Ye</creator><creator>Hao, Qiulian</creator><creator>Bi, Yanping</creator><creator>He, Yujing</creator><creator>Zhao, Jing</creator><creator>Hao, Jifu</creator><general>Versita</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20220201</creationdate><title>Fabrication and in vitro/in vivo characterization of Eudragit enteric nanoparticles loaded with indomethacin</title><author>Wang, Xingrong ; Wang, Mufang ; Wang, Qi ; Yuan, Ye ; Hao, Qiulian ; Bi, Yanping ; He, Yujing ; Zhao, Jing ; Hao, Jifu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-d68ebc0bf9a5260f0d4b7a0aff8735b65780c8ff36a4f8c00206c087a4279f6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biochemistry</topic><topic>Biotechnology</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Design optimization</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Materials Science</topic><topic>Medicinal Chemistry</topic><topic>Molecular interactions</topic><topic>Nanoparticles</topic><topic>Original Paper</topic><topic>Pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xingrong</creatorcontrib><creatorcontrib>Wang, Mufang</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Yuan, Ye</creatorcontrib><creatorcontrib>Hao, Qiulian</creatorcontrib><creatorcontrib>Bi, Yanping</creatorcontrib><creatorcontrib>He, Yujing</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><creatorcontrib>Hao, Jifu</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical papers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xingrong</au><au>Wang, Mufang</au><au>Wang, Qi</au><au>Yuan, Ye</au><au>Hao, Qiulian</au><au>Bi, Yanping</au><au>He, Yujing</au><au>Zhao, Jing</au><au>Hao, Jifu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fabrication and in vitro/in vivo characterization of Eudragit enteric nanoparticles loaded with indomethacin</atitle><jtitle>Chemical papers</jtitle><stitle>Chem. Pap</stitle><date>2022-02-01</date><risdate>2022</risdate><volume>76</volume><issue>2</issue><spage>1119</spage><epage>1133</epage><pages>1119-1133</pages><issn>0366-6352</issn><eissn>1336-9075</eissn><eissn>2585-7290</eissn><abstract>The purpose of this study was to tailor and evaluate indomethacin-loaded Eudragit L 100–55 enteric nanoparticles (IDM@NPs). Nanoprecipitation approach was used to fabricate IDM@NPs, and the formulation was optimized by a central composite design (CCD). The physicochemical properties of IDM@NPs were characterized by FTIR, XRD and DSC, respectively. Furthermore, in situ intestinal perfusion, in vivo pharmacokinetic analysis and pharmacodynamics experiments were performed. The obtained IDM@NPs were in spherical shape. The results of FITC, XRD and DSC indicated that no molecular interaction occurred and no crystal drug present in the nanoparticles. The in vitro release confirmed the pH-sensitive released profiles of IDM@NPs. The
C
max
and
AUC
of IDM@NPs were about 1.24-fold and 1.39-fold greater than those of given coarse IDM group. In addition, the therapeutic activity illustrated that IDM@NPs have the similar anti-inflammatory and analgesic effects as compared with IDM suspensions, while there were no statistical differences between the high- and low-dose group of IDM@NPs. The present study demonstrated the enteric nanoparticles could be used as potential therapeutic platforms for oral delivery of IDM.</abstract><cop>Warsaw</cop><pub>Versita</pub><doi>10.1007/s11696-021-01921-3</doi><tpages>15</tpages></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Biochemistry Biotechnology Chemistry Chemistry and Materials Science Chemistry/Food Science Design optimization Industrial Chemistry/Chemical Engineering Materials Science Medicinal Chemistry Molecular interactions Nanoparticles Original Paper Pharmacology |
| title | Fabrication and in vitro/in vivo characterization of Eudragit enteric nanoparticles loaded with indomethacin |
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