Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair

Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair. Using a murine model of ischemic cardiac injury, we demonstrate that cardiomyocytes play a pivotal role in heart repair by regulating nucleot...

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Veröffentlicht in:	The Journal of clinical investigation 2022-01, Vol.132 (2), p.0_1-21
Hauptverfasser:	Li, Shen, Yokota, Tomohiro, Wang, Ping, Hoeve, Johanna Ten, Ma, Feiyang, Le, Thuc M, Abt, Evan R, Zhou, Yonggang, Wu, Rimao, Nanthavongdouangsy, Maxine, Rodriguez, Abraham, Wang, Yijie, Lin, Yen-Ju, Muranaka, Hayato, Sharpley, Mark, Braddock, Demetrios T, MacRae, Vicky E, Banerjee, Utpal, Chiou, Pei-Yu, Seldin, Marcus, Huang, Dian, Teitell, Michael, Gertsman, Ilya, Jung, Michael, Bensinger, Steven J, Damoiseaux, Robert, Faull, Kym, Pellegrini, Matteo, Lusis, Aldons J, Graeber, Thomas G, Radu, Caius G, Deb, Arjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine AMP Animal models Apoptosis Biomedical research Biosynthesis Cardiac muscle Cardiomyocytes Cell death Cell growth Ectonucleotidase Fibroblasts Flow cytometry Genotoxicity Heart Ischemia Metabolism Metabolites p53 Protein Phosphodiesterase Proteins Pyrophosphatase Uridine Wound healing
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