Effects of IL-33 on 3T3-L1 cells and obese mice models induced by a high-fat diet

•The content of IL-33 is different in various adipose tissues in obese mice fed a HFD diet.•The exogenous IL-33 reduces lipid accumulation in 3 T3-L1 cells and adipose tissue of obese mice.•The exogenous IL-33 alleviates type 1 inflammation and improves glucose and lipid metabolism in HFD-induced mi...

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Veröffentlicht in:	International immunopharmacology 2021-12, Vol.101 (Pt A), p.108209-108209, Article 108209
Hauptverfasser:	Kai, Yue, Gao, Jingtao, Liu, Hu, Wang, Yubing, Tian, Chenrui, Guo, Sheng, He, Ling, Li, Min, Tian, Zhongwei, Song, Xiangfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 cells 3T3-L1 Cells - drug effects 3T3-L1 Cells - metabolism Adipogenesis - drug effects Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Animal models Animals Blotting, Western Cell culture Diet Diet, High-Fat - adverse effects Fatty liver Flow Cytometry Genetics Glucose tolerance Health services High fat diet Immune response Immunological tolerance Immunology Immunoregulation In vivo methods and tests Inflammation Inflammatory response Insulin Interleukin 1 Interleukin 33 Interleukin-33 - blood Interleukin-33 - metabolism Interleukin-33 - pharmacology Life Sciences & Biomedicine Lipid metabolism Lipids Liver Male Metabolic disorders Metabolic Syndrome - drug therapy Metabolic Syndrome - etiology Metabolism Mice Mice, Inbred C57BL Muscles Obesity Obesity - immunology Obesity - metabolism Peroxisome proliferator-activated receptors Pharmacology & Pharmacy Real-Time Polymerase Chain Reaction Science & Technology Spleen Steatosis Therapeutic targets
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