Morphology transition of polyion complex (PIC) micelles with carboxybetaine as a shell induced at different block ratios and their pH-responsivity
In this study, we investigated the morphology transition of polyion complex (PIC) micelles with the change in block ratio and pH-responsivity of PIC micelles or vesicles using entirely ionic diblock copolymers composed of carboxybetaine and ionic blocks. We used 2-((2-(methacryloylo-xy)ethyl)dimethy...
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| Veröffentlicht in: | Colloid and polymer science 2022-02, Vol.300 (2), p.125-138 |
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| creator | Kim, Dongwook Honda, Hiro Matsuoka, Hideki Yusa, Shin-ichi Saruwatari, Yoshiyuki |
| description | In this study, we investigated the morphology transition of polyion complex (PIC) micelles with the change in block ratio and pH-responsivity of PIC micelles or vesicles using entirely ionic diblock copolymers composed of carboxybetaine and ionic blocks. We used 2-((2-(methacryloylo-xy)ethyl)dimethylammonio)acetate (PGLBT) as carboxybetaine, poly(sodium styrenesulfonate) (PSSNa) as the anionic polymer, and poly[3-(methacrylamido)propyltrimethylammonium chlorid-e] (PMAPTAC) as the cationic polymer. The effect of pH on the PGLBT homopolymer and the PGLBT-containing diblock copolymer was examined by DLS, ELS, and transmittance, and a rapid change of state was observed between pH 4 and 2. At this pH, the carboxyl group of PGLBT was protonated to form a hydrogen bond in the molecule. Furthermore, at a lower pH, diblock copolymer behaved like a cationic polymer. The formation behavior of PIC micelles at different block ratios in the diblock copolymers was investigated by DLS, SLS, TEM, and AFM. PIC vesicles formed when the block ratio of ionic blocks to the PGLBT block was equal or larger (the content of PGLBT was 52% or less). On the other hand, PIC micelles were formed when the block ratio of PGLBT to ionic blocks was larger (the content of PGLBT was 68% or more). The pH-responsivity of PIC micelles was different from that of PIC vesicles. The size of PIC vesicles decreased by lowering pH and increased when the below pH 3. The behavior was the same as the change of state of PGLBT homopolymer with the change in pH. However, the size of PIC micelles increased by lowering pH from pH 6 to 3 and decreased at pH below pH 3. The PGLBT, which became the shell, changed its state with the change in pH and affected the aggregation number of micelles.
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| doi_str_mv | 10.1007/s00396-021-04921-7 |
| format | Article |
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Graphical Abstract</description><identifier>ISSN: 0303-402X</identifier><identifier>EISSN: 1435-1536</identifier><identifier>DOI: 10.1007/s00396-021-04921-7</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Block copolymers ; Carboxyl group ; Cationic polymerization ; Characterization and Evaluation of Materials ; Chemical bonds ; Chemistry ; Chemistry and Materials Science ; Complex Fluids and Microfluidics ; Food Science ; Hydrogen bonds ; Micelles ; Morphology ; Nanotechnology and Microengineering ; Original Contribution ; Physical Chemistry ; Polymer Sciences ; Polymers ; Soft and Granular Matter ; Vesicles</subject><ispartof>Colloid and polymer science, 2022-02, Vol.300 (2), p.125-138</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-eb5416fa74412cef141c411e88896780a955dc15682a9f80d35c4dcfe53200d83</citedby><cites>FETCH-LOGICAL-c319t-eb5416fa74412cef141c411e88896780a955dc15682a9f80d35c4dcfe53200d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00396-021-04921-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00396-021-04921-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Kim, Dongwook</creatorcontrib><creatorcontrib>Honda, Hiro</creatorcontrib><creatorcontrib>Matsuoka, Hideki</creatorcontrib><creatorcontrib>Yusa, Shin-ichi</creatorcontrib><creatorcontrib>Saruwatari, Yoshiyuki</creatorcontrib><title>Morphology transition of polyion complex (PIC) micelles with carboxybetaine as a shell induced at different block ratios and their pH-responsivity</title><title>Colloid and polymer science</title><addtitle>Colloid Polym Sci</addtitle><description>In this study, we investigated the morphology transition of polyion complex (PIC) micelles with the change in block ratio and pH-responsivity of PIC micelles or vesicles using entirely ionic diblock copolymers composed of carboxybetaine and ionic blocks. We used 2-((2-(methacryloylo-xy)ethyl)dimethylammonio)acetate (PGLBT) as carboxybetaine, poly(sodium styrenesulfonate) (PSSNa) as the anionic polymer, and poly[3-(methacrylamido)propyltrimethylammonium chlorid-e] (PMAPTAC) as the cationic polymer. The effect of pH on the PGLBT homopolymer and the PGLBT-containing diblock copolymer was examined by DLS, ELS, and transmittance, and a rapid change of state was observed between pH 4 and 2. At this pH, the carboxyl group of PGLBT was protonated to form a hydrogen bond in the molecule. Furthermore, at a lower pH, diblock copolymer behaved like a cationic polymer. The formation behavior of PIC micelles at different block ratios in the diblock copolymers was investigated by DLS, SLS, TEM, and AFM. PIC vesicles formed when the block ratio of ionic blocks to the PGLBT block was equal or larger (the content of PGLBT was 52% or less). On the other hand, PIC micelles were formed when the block ratio of PGLBT to ionic blocks was larger (the content of PGLBT was 68% or more). The pH-responsivity of PIC micelles was different from that of PIC vesicles. The size of PIC vesicles decreased by lowering pH and increased when the below pH 3. The behavior was the same as the change of state of PGLBT homopolymer with the change in pH. However, the size of PIC micelles increased by lowering pH from pH 6 to 3 and decreased at pH below pH 3. The PGLBT, which became the shell, changed its state with the change in pH and affected the aggregation number of micelles.
Graphical Abstract</description><subject>Block copolymers</subject><subject>Carboxyl group</subject><subject>Cationic polymerization</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical bonds</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Complex Fluids and Microfluidics</subject><subject>Food Science</subject><subject>Hydrogen bonds</subject><subject>Micelles</subject><subject>Morphology</subject><subject>Nanotechnology and Microengineering</subject><subject>Original Contribution</subject><subject>Physical Chemistry</subject><subject>Polymer Sciences</subject><subject>Polymers</subject><subject>Soft and Granular Matter</subject><subject>Vesicles</subject><issn>0303-402X</issn><issn>1435-1536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kE1v1DAQhi0EEkvhD3AaiQscUsYfcZIjWlFaqQgOIHGzvM6465KNg-2F5m_wi3G7SNy4zMzheeeVHsZecjzniN3bjCgH3aDgDaqhzu4R23Al24a3Uj9mG5QoG4Xi21P2LOdbxIppvWG_P8a07OMUb1Yoyc45lBBniB6WOK33p4uHZaI7eP35avsGDsHRNFGGX6Hswdm0i3frjooNM4HNYCHvKwBhHo-ORrAFxuA9JZoL7KbovkOytaKS8whlTyHBctkkykus5T9DWZ-zJ95OmV783Wfs68X7L9vL5vrTh6vtu-vGST6Uhnat4trbTikuHHmuuFOcU9_3g-56tEPbjo63uhd28D2OsnVqdJ5aKRDHXp6xV6e_S4o_jpSLuY3HNNdKI7QQutNcDZUSJ8qlmHMib5YUDjathqO5d29O7k11bx7cm66G5CmUKzzfUPr3-j-pPx2OiT0</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Kim, Dongwook</creator><creator>Honda, Hiro</creator><creator>Matsuoka, Hideki</creator><creator>Yusa, Shin-ichi</creator><creator>Saruwatari, Yoshiyuki</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20220201</creationdate><title>Morphology transition of polyion complex (PIC) micelles with carboxybetaine as a shell induced at different block ratios and their pH-responsivity</title><author>Kim, Dongwook ; Honda, Hiro ; Matsuoka, Hideki ; Yusa, Shin-ichi ; Saruwatari, Yoshiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-eb5416fa74412cef141c411e88896780a955dc15682a9f80d35c4dcfe53200d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Block copolymers</topic><topic>Carboxyl group</topic><topic>Cationic polymerization</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemical bonds</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Complex Fluids and Microfluidics</topic><topic>Food Science</topic><topic>Hydrogen bonds</topic><topic>Micelles</topic><topic>Morphology</topic><topic>Nanotechnology and Microengineering</topic><topic>Original Contribution</topic><topic>Physical Chemistry</topic><topic>Polymer Sciences</topic><topic>Polymers</topic><topic>Soft and Granular Matter</topic><topic>Vesicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Dongwook</creatorcontrib><creatorcontrib>Honda, Hiro</creatorcontrib><creatorcontrib>Matsuoka, Hideki</creatorcontrib><creatorcontrib>Yusa, Shin-ichi</creatorcontrib><creatorcontrib>Saruwatari, Yoshiyuki</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Colloid and polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Dongwook</au><au>Honda, Hiro</au><au>Matsuoka, Hideki</au><au>Yusa, Shin-ichi</au><au>Saruwatari, Yoshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphology transition of polyion complex (PIC) micelles with carboxybetaine as a shell induced at different block ratios and their pH-responsivity</atitle><jtitle>Colloid and polymer science</jtitle><stitle>Colloid Polym Sci</stitle><date>2022-02-01</date><risdate>2022</risdate><volume>300</volume><issue>2</issue><spage>125</spage><epage>138</epage><pages>125-138</pages><issn>0303-402X</issn><eissn>1435-1536</eissn><abstract>In this study, we investigated the morphology transition of polyion complex (PIC) micelles with the change in block ratio and pH-responsivity of PIC micelles or vesicles using entirely ionic diblock copolymers composed of carboxybetaine and ionic blocks. We used 2-((2-(methacryloylo-xy)ethyl)dimethylammonio)acetate (PGLBT) as carboxybetaine, poly(sodium styrenesulfonate) (PSSNa) as the anionic polymer, and poly[3-(methacrylamido)propyltrimethylammonium chlorid-e] (PMAPTAC) as the cationic polymer. The effect of pH on the PGLBT homopolymer and the PGLBT-containing diblock copolymer was examined by DLS, ELS, and transmittance, and a rapid change of state was observed between pH 4 and 2. At this pH, the carboxyl group of PGLBT was protonated to form a hydrogen bond in the molecule. Furthermore, at a lower pH, diblock copolymer behaved like a cationic polymer. The formation behavior of PIC micelles at different block ratios in the diblock copolymers was investigated by DLS, SLS, TEM, and AFM. PIC vesicles formed when the block ratio of ionic blocks to the PGLBT block was equal or larger (the content of PGLBT was 52% or less). On the other hand, PIC micelles were formed when the block ratio of PGLBT to ionic blocks was larger (the content of PGLBT was 68% or more). The pH-responsivity of PIC micelles was different from that of PIC vesicles. The size of PIC vesicles decreased by lowering pH and increased when the below pH 3. The behavior was the same as the change of state of PGLBT homopolymer with the change in pH. However, the size of PIC micelles increased by lowering pH from pH 6 to 3 and decreased at pH below pH 3. The PGLBT, which became the shell, changed its state with the change in pH and affected the aggregation number of micelles.
Graphical Abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00396-021-04921-7</doi><tpages>14</tpages></addata></record> |
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| subjects | Block copolymers Carboxyl group Cationic polymerization Characterization and Evaluation of Materials Chemical bonds Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Food Science Hydrogen bonds Micelles Morphology Nanotechnology and Microengineering Original Contribution Physical Chemistry Polymer Sciences Polymers Soft and Granular Matter Vesicles |
| title | Morphology transition of polyion complex (PIC) micelles with carboxybetaine as a shell induced at different block ratios and their pH-responsivity |
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