Survey reactivity of 2-aminopyridine and Meldrum’s acid in the presence of aryl glyoxals or aryl aldehydes; ethyl 2-(3-aryl imidazo[1,2-a]pyridin-2-yl)acetates versus ethyl 3-aryl-3-(pyridin-2-ylamino)propanoates

Survey reactivity of 2-aminopyridine and Meldrum’s acid in the presence of aryl glyoxals or aryl aldehydes; ethyl 2-(3-aryl imidazo[1,2-a]pyridin-2-yl)acetates versus ethyl 3-aryl-3-(pyridin-2-ylamino)propanoates

The aim of present investigation is survey reactivity of 2-aminopyridine and Meldrum’s acid in the presence of aryl glyoxals or aryl aldehydes. The ethyl 2-(3-aryl imidazo[1,2- a ]pyridin-2- yl )acetates were successfully synthesized by reaction of 2-aminopyridine, Meldrum’s acid, and aryl glyoxals,...

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Veröffentlicht in:Research on chemical intermediates 2022, Vol.48 (1), p.251-265
Hauptverfasser: Asadi, Sara, Zebarjad, Maedeh, Masoudi, Hamidreza, Mehrabi, Hossein
Format: Artikel
Sprache:eng
Schlagworte:
Acetates
Acetic acid
Acids
Aldehydes
Aromatic compounds
Catalysis
Chemical reactions
Chemical synthesis
Chemistry
Chemistry and Materials Science
Ethanol
Inorganic Chemistry
Physical Chemistry
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Zusammenfassung:The aim of present investigation is survey reactivity of 2-aminopyridine and Meldrum’s acid in the presence of aryl glyoxals or aryl aldehydes. The ethyl 2-(3-aryl imidazo[1,2- a ]pyridin-2- yl )acetates were successfully synthesized by reaction of 2-aminopyridine, Meldrum’s acid, and aryl glyoxals, while the ethyl 3-aryl-3-(pyridin-2-ylamino)propanoates were synthesized in the presence of aryl aldehydes. The reactions are performed in ethanol, catalyzed by acetic acid at reflux and microwave conditions. Graphic abstract
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-021-04554-z