Impact of TAILORx on chemotherapy prescribing and 21‐gene recurrence score–guided treatment costs in a population‐based cohort of patients with breast cancer
Background The trial assigning individualized options for treatment (Rx) (TAILORx) confirmed the predictive value of the 21‐gene recurrence score (RS) assay in hormone receptor (HR)–positive, HER2‐negative, node‐negative breast cancer and established thresholds for chemotherapy benefit in younger an...
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| Veröffentlicht in: | Cancer 2022-02, Vol.128 (4), p.665-674 |
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| creator | Tesch, Megan E. Speers, Caroline Diocee, Rekha M. Gondara, Lovedeep Peacock, Stuart J. Nichol, Alan Lohrisch, Caroline A. |
| description | Background
The trial assigning individualized options for treatment (Rx) (TAILORx) confirmed the predictive value of the 21‐gene recurrence score (RS) assay in hormone receptor (HR)–positive, HER2‐negative, node‐negative breast cancer and established thresholds for chemotherapy benefit in younger and older patients. Real‐world chemotherapy use and RS‐guided treatment costs in British Columbia post‐TAILORx were examined.
Methods
The authors assembled 3 cohorts of HR‐positive, HER2‐negative, node‐negative patients with breast cancer defined by diagnosis: before RS funding (cohort 1 [C1]: January 2013‐December 2013), after introduction of public RS funding (cohort 2 [C2]: July 2015‐June 2016), and after TAILORx results (cohort 3 [C3]: July 2018‐June 2019). Chemotherapy use was compared between cohorts by age and RS. Budgetary impacts of RS testing on chemotherapy costs were evaluated pre‐ and post‐TAILORx.
Results
Among the 2066 patients included, chemotherapy use declined by 19% after RS funding was introduced and by an additional 23% after TAILORx publication (P = .001). Reduction in chemotherapy use was significant for RS 11‐20 tumors (C3 vs C2, P = .004). There was no significant change in chemotherapy use in patients >50 years old (C2:12% vs C3:10%, P = .22). RS testing was associated with higher cost savings post‐TAILORx, except in patients 70 to 80 years old, where testing led to excess costs when adjusting for the low rate of RS‐concordant chemotherapy prescribed.
Conclusions
TAILORx has had population‐based impacts on chemotherapy prescribing in intermediate RS tumors and patients ≤50 years old. The lower clinical use of RS and increased spending in patients 70‐80 years old highlights the importance of careful selection of older candidates for high‐cost genomic testing.
Lay Summary
The 21‐gene recurrence score (RS) test helps predict whether patients with hormone‐positive, HER2‐negative, lymph node‐negative breast cancer are likely to benefit from chemotherapy.
The recent trial assigning individualized options for treatment (Rx) (TAILORx) found that patients with intermediate RS tumors did not benefit from chemotherapy.
The authors assessed whether TAILORx results translated to real‐world changes in chemotherapy prescribing patterns.
In this study, chemotherapy use decreased by 23% after TAILORx, with the greatest reductions seen among intermediate RS tumors and younger patients.
In contrast, RS testing had lower clinical value and increased treatmen |
| doi_str_mv | 10.1002/cncr.33982 |
| format | Article |
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The trial assigning individualized options for treatment (Rx) (TAILORx) confirmed the predictive value of the 21‐gene recurrence score (RS) assay in hormone receptor (HR)–positive, HER2‐negative, node‐negative breast cancer and established thresholds for chemotherapy benefit in younger and older patients. Real‐world chemotherapy use and RS‐guided treatment costs in British Columbia post‐TAILORx were examined.
Methods
The authors assembled 3 cohorts of HR‐positive, HER2‐negative, node‐negative patients with breast cancer defined by diagnosis: before RS funding (cohort 1 [C1]: January 2013‐December 2013), after introduction of public RS funding (cohort 2 [C2]: July 2015‐June 2016), and after TAILORx results (cohort 3 [C3]: July 2018‐June 2019). Chemotherapy use was compared between cohorts by age and RS. Budgetary impacts of RS testing on chemotherapy costs were evaluated pre‐ and post‐TAILORx.
Results
Among the 2066 patients included, chemotherapy use declined by 19% after RS funding was introduced and by an additional 23% after TAILORx publication (P = .001). Reduction in chemotherapy use was significant for RS 11‐20 tumors (C3 vs C2, P = .004). There was no significant change in chemotherapy use in patients >50 years old (C2:12% vs C3:10%, P = .22). RS testing was associated with higher cost savings post‐TAILORx, except in patients 70 to 80 years old, where testing led to excess costs when adjusting for the low rate of RS‐concordant chemotherapy prescribed.
Conclusions
TAILORx has had population‐based impacts on chemotherapy prescribing in intermediate RS tumors and patients ≤50 years old. The lower clinical use of RS and increased spending in patients 70‐80 years old highlights the importance of careful selection of older candidates for high‐cost genomic testing.
Lay Summary
The 21‐gene recurrence score (RS) test helps predict whether patients with hormone‐positive, HER2‐negative, lymph node‐negative breast cancer are likely to benefit from chemotherapy.
The recent trial assigning individualized options for treatment (Rx) (TAILORx) found that patients with intermediate RS tumors did not benefit from chemotherapy.
The authors assessed whether TAILORx results translated to real‐world changes in chemotherapy prescribing patterns.
In this study, chemotherapy use decreased by 23% after TAILORx, with the greatest reductions seen among intermediate RS tumors and younger patients.
In contrast, RS testing had lower clinical value and increased treatment costs in elderly patients, which requires further study to ensure optimal care for this age group.
The TAILORx trial has led to real‐world declines in adjuvant chemotherapy use in breast tumors with an intermediate‐risk 21‐gene recurrence score (RS) and in patients 50 years old or younger. RS testing has lower clinical utility and is associated with excess treatment costs in patients 70 to 80 years old; this reveals important age‐specific discordances in assay value that require further consideration.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.33982</identifier><identifier>PMID: 34855202</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>age factors ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - genetics ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Chemotherapy ; Chemotherapy, Adjuvant ; Cost control ; Costs ; cost‐benefit analysis ; ErbB-2 protein ; Female ; Funding ; Gene Expression Profiling ; Health Care Costs ; health services needs and demands ; Humans ; Lymph nodes ; Middle Aged ; Neoplasm Recurrence, Local - drug therapy ; Neoplasm Recurrence, Local - genetics ; Oncology ; Patients ; predictive genetic testing ; Prognosis ; quality of health care ; Tumors</subject><ispartof>Cancer, 2022-02, Vol.128 (4), p.665-674</ispartof><rights>2021 American Cancer Society</rights><rights>2021 American Cancer Society.</rights><rights>2022 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3932-da05578990a95bc41dd6727b64445a9e2ed5dab74e2c9ee029f3ce9f9255a3693</citedby><cites>FETCH-LOGICAL-c3932-da05578990a95bc41dd6727b64445a9e2ed5dab74e2c9ee029f3ce9f9255a3693</cites><orcidid>0000-0002-4146-881X ; 0000-0002-8243-8721 ; 0000-0001-6568-726X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.33982$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.33982$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34855202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tesch, Megan E.</creatorcontrib><creatorcontrib>Speers, Caroline</creatorcontrib><creatorcontrib>Diocee, Rekha M.</creatorcontrib><creatorcontrib>Gondara, Lovedeep</creatorcontrib><creatorcontrib>Peacock, Stuart J.</creatorcontrib><creatorcontrib>Nichol, Alan</creatorcontrib><creatorcontrib>Lohrisch, Caroline A.</creatorcontrib><title>Impact of TAILORx on chemotherapy prescribing and 21‐gene recurrence score–guided treatment costs in a population‐based cohort of patients with breast cancer</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Background
The trial assigning individualized options for treatment (Rx) (TAILORx) confirmed the predictive value of the 21‐gene recurrence score (RS) assay in hormone receptor (HR)–positive, HER2‐negative, node‐negative breast cancer and established thresholds for chemotherapy benefit in younger and older patients. Real‐world chemotherapy use and RS‐guided treatment costs in British Columbia post‐TAILORx were examined.
Methods
The authors assembled 3 cohorts of HR‐positive, HER2‐negative, node‐negative patients with breast cancer defined by diagnosis: before RS funding (cohort 1 [C1]: January 2013‐December 2013), after introduction of public RS funding (cohort 2 [C2]: July 2015‐June 2016), and after TAILORx results (cohort 3 [C3]: July 2018‐June 2019). Chemotherapy use was compared between cohorts by age and RS. Budgetary impacts of RS testing on chemotherapy costs were evaluated pre‐ and post‐TAILORx.
Results
Among the 2066 patients included, chemotherapy use declined by 19% after RS funding was introduced and by an additional 23% after TAILORx publication (P = .001). Reduction in chemotherapy use was significant for RS 11‐20 tumors (C3 vs C2, P = .004). There was no significant change in chemotherapy use in patients >50 years old (C2:12% vs C3:10%, P = .22). RS testing was associated with higher cost savings post‐TAILORx, except in patients 70 to 80 years old, where testing led to excess costs when adjusting for the low rate of RS‐concordant chemotherapy prescribed.
Conclusions
TAILORx has had population‐based impacts on chemotherapy prescribing in intermediate RS tumors and patients ≤50 years old. The lower clinical use of RS and increased spending in patients 70‐80 years old highlights the importance of careful selection of older candidates for high‐cost genomic testing.
Lay Summary
The 21‐gene recurrence score (RS) test helps predict whether patients with hormone‐positive, HER2‐negative, lymph node‐negative breast cancer are likely to benefit from chemotherapy.
The recent trial assigning individualized options for treatment (Rx) (TAILORx) found that patients with intermediate RS tumors did not benefit from chemotherapy.
The authors assessed whether TAILORx results translated to real‐world changes in chemotherapy prescribing patterns.
In this study, chemotherapy use decreased by 23% after TAILORx, with the greatest reductions seen among intermediate RS tumors and younger patients.
In contrast, RS testing had lower clinical value and increased treatment costs in elderly patients, which requires further study to ensure optimal care for this age group.
The TAILORx trial has led to real‐world declines in adjuvant chemotherapy use in breast tumors with an intermediate‐risk 21‐gene recurrence score (RS) and in patients 50 years old or younger. RS testing has lower clinical utility and is associated with excess treatment costs in patients 70 to 80 years old; this reveals important age‐specific discordances in assay value that require further consideration.</description><subject>age factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Cost control</subject><subject>Costs</subject><subject>cost‐benefit analysis</subject><subject>ErbB-2 protein</subject><subject>Female</subject><subject>Funding</subject><subject>Gene Expression Profiling</subject><subject>Health Care Costs</subject><subject>health services needs and demands</subject><subject>Humans</subject><subject>Lymph nodes</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - drug therapy</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Oncology</subject><subject>Patients</subject><subject>predictive genetic testing</subject><subject>Prognosis</subject><subject>quality of health care</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFqGzEQhkVoiN0klzxAEfQW2FQrrbzWMZimNZgGggO5LVpp1l7jlbYjLalveYRCH6FvliepErs55jQM8_3fHH5CLnJ2lTPGvxhn8EoINeVHZJwzVWYsL_gHMmaMTTNZiIcR-RjCJq0ll-KEjEQxlZIzPiZ_512vTaS-ocvr-eL27hf1jpo1dD6uAXW_oz1CMNjWrVtR7Szl-fPT7xU4oAhmQARngAbjEZ6f_qyG1oKlEUHHDlykxocYaOuopr3vh62OrXdJUOuQOOPXHl-_9-mQ-EAf27imdcqHFNbJjWfkuNHbAOeHeUrub74uZ9-zxe23-ex6kRmhBM-sZlKWU6WYVrI2RW7tpORlPSmKQmoFHKy0ui4L4EYBMK4aYUA1ikupxUSJU_J57-3R_xwgxGrjB3TpZcUnnEulhBSJutxTBn0ICE3VY9tp3FU5q176qF76qF77SPCng3KoO7Bv6P8CEpDvgcd2C7t3VNXsx-xuL_0HUpabIA</recordid><startdate>20220215</startdate><enddate>20220215</enddate><creator>Tesch, Megan E.</creator><creator>Speers, Caroline</creator><creator>Diocee, Rekha M.</creator><creator>Gondara, Lovedeep</creator><creator>Peacock, Stuart J.</creator><creator>Nichol, Alan</creator><creator>Lohrisch, Caroline A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0002-4146-881X</orcidid><orcidid>https://orcid.org/0000-0002-8243-8721</orcidid><orcidid>https://orcid.org/0000-0001-6568-726X</orcidid></search><sort><creationdate>20220215</creationdate><title>Impact of TAILORx on chemotherapy prescribing and 21‐gene recurrence score–guided treatment costs in a population‐based cohort of patients with breast cancer</title><author>Tesch, Megan E. ; Speers, Caroline ; Diocee, Rekha M. ; Gondara, Lovedeep ; Peacock, Stuart J. ; Nichol, Alan ; Lohrisch, Caroline A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3932-da05578990a95bc41dd6727b64445a9e2ed5dab74e2c9ee029f3ce9f9255a3693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>age factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Cost control</topic><topic>Costs</topic><topic>cost‐benefit analysis</topic><topic>ErbB-2 protein</topic><topic>Female</topic><topic>Funding</topic><topic>Gene Expression Profiling</topic><topic>Health Care Costs</topic><topic>health services needs and demands</topic><topic>Humans</topic><topic>Lymph nodes</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - drug therapy</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Oncology</topic><topic>Patients</topic><topic>predictive genetic testing</topic><topic>Prognosis</topic><topic>quality of health care</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tesch, Megan E.</creatorcontrib><creatorcontrib>Speers, Caroline</creatorcontrib><creatorcontrib>Diocee, Rekha M.</creatorcontrib><creatorcontrib>Gondara, Lovedeep</creatorcontrib><creatorcontrib>Peacock, Stuart J.</creatorcontrib><creatorcontrib>Nichol, Alan</creatorcontrib><creatorcontrib>Lohrisch, Caroline A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tesch, Megan E.</au><au>Speers, Caroline</au><au>Diocee, Rekha M.</au><au>Gondara, Lovedeep</au><au>Peacock, Stuart J.</au><au>Nichol, Alan</au><au>Lohrisch, Caroline A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of TAILORx on chemotherapy prescribing and 21‐gene recurrence score–guided treatment costs in a population‐based cohort of patients with breast cancer</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2022-02-15</date><risdate>2022</risdate><volume>128</volume><issue>4</issue><spage>665</spage><epage>674</epage><pages>665-674</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Background
The trial assigning individualized options for treatment (Rx) (TAILORx) confirmed the predictive value of the 21‐gene recurrence score (RS) assay in hormone receptor (HR)–positive, HER2‐negative, node‐negative breast cancer and established thresholds for chemotherapy benefit in younger and older patients. Real‐world chemotherapy use and RS‐guided treatment costs in British Columbia post‐TAILORx were examined.
Methods
The authors assembled 3 cohorts of HR‐positive, HER2‐negative, node‐negative patients with breast cancer defined by diagnosis: before RS funding (cohort 1 [C1]: January 2013‐December 2013), after introduction of public RS funding (cohort 2 [C2]: July 2015‐June 2016), and after TAILORx results (cohort 3 [C3]: July 2018‐June 2019). Chemotherapy use was compared between cohorts by age and RS. Budgetary impacts of RS testing on chemotherapy costs were evaluated pre‐ and post‐TAILORx.
Results
Among the 2066 patients included, chemotherapy use declined by 19% after RS funding was introduced and by an additional 23% after TAILORx publication (P = .001). Reduction in chemotherapy use was significant for RS 11‐20 tumors (C3 vs C2, P = .004). There was no significant change in chemotherapy use in patients >50 years old (C2:12% vs C3:10%, P = .22). RS testing was associated with higher cost savings post‐TAILORx, except in patients 70 to 80 years old, where testing led to excess costs when adjusting for the low rate of RS‐concordant chemotherapy prescribed.
Conclusions
TAILORx has had population‐based impacts on chemotherapy prescribing in intermediate RS tumors and patients ≤50 years old. The lower clinical use of RS and increased spending in patients 70‐80 years old highlights the importance of careful selection of older candidates for high‐cost genomic testing.
Lay Summary
The 21‐gene recurrence score (RS) test helps predict whether patients with hormone‐positive, HER2‐negative, lymph node‐negative breast cancer are likely to benefit from chemotherapy.
The recent trial assigning individualized options for treatment (Rx) (TAILORx) found that patients with intermediate RS tumors did not benefit from chemotherapy.
The authors assessed whether TAILORx results translated to real‐world changes in chemotherapy prescribing patterns.
In this study, chemotherapy use decreased by 23% after TAILORx, with the greatest reductions seen among intermediate RS tumors and younger patients.
In contrast, RS testing had lower clinical value and increased treatment costs in elderly patients, which requires further study to ensure optimal care for this age group.
The TAILORx trial has led to real‐world declines in adjuvant chemotherapy use in breast tumors with an intermediate‐risk 21‐gene recurrence score (RS) and in patients 50 years old or younger. RS testing has lower clinical utility and is associated with excess treatment costs in patients 70 to 80 years old; this reveals important age‐specific discordances in assay value that require further consideration.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34855202</pmid><doi>10.1002/cncr.33982</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4146-881X</orcidid><orcidid>https://orcid.org/0000-0002-8243-8721</orcidid><orcidid>https://orcid.org/0000-0001-6568-726X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | age factors Aged Aged, 80 and over Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Chemotherapy Chemotherapy, Adjuvant Cost control Costs cost‐benefit analysis ErbB-2 protein Female Funding Gene Expression Profiling Health Care Costs health services needs and demands Humans Lymph nodes Middle Aged Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - genetics Oncology Patients predictive genetic testing Prognosis quality of health care Tumors |
| title | Impact of TAILORx on chemotherapy prescribing and 21‐gene recurrence score–guided treatment costs in a population‐based cohort of patients with breast cancer |
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