Presumed adrenal insufficiency in neonates treated with corticosteroids for the prevention of bronchopulmonary dysplasia
Objective To determine if extremely preterm (EPT) neonates receiving dexamethasone for the prevention of BPD have a higher incidence of presumed adrenal insufficiency (PAI). Study design Retrospective cohort study of neonates
Gespeichert in:
| Veröffentlicht in: | Journal of perinatology 2022-01, Vol.42 (1), p.65-71 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 71 |
|---|---|
| container_issue | 1 |
| container_start_page | 65 |
| container_title | Journal of perinatology |
| container_volume | 42 |
| creator | Josephsen, Justin B. Hemmann, Brianna M. Anderson, Connie D. Hemmann, Brett M. Buchanan, Paula M. Williams, Howard L. Lubsch, Lisa M. Hillman, Noah H. |
| description | Objective
To determine if extremely preterm (EPT) neonates receiving dexamethasone for the prevention of BPD have a higher incidence of presumed adrenal insufficiency (PAI).
Study design
Retrospective cohort study of neonates |
| doi_str_mv | 10.1038/s41372-021-01251-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2622379320</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2622379320</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-6ca1fd11a0e2cf30216462a05227ef8fafbc65033c31fbe90fae50883a41f59d3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EgvL4ARbIEuuAn0m6RIiXhAQLWFuuM6auWjvYDpC_x9ACO1aj0dy5c-cgdEzJGSW8PU-C8oZVhNGKUCZpNW6hCRVNXUkp-DaakEbwquWi3kP7KS0I-Ro2u2iPi4ZJIaYT9PEYIQ0r6LDuIni9xM6nwVpnHHgzlg57CF5nSDhHKLXD7y7PsQkxOxNShhhcl7ANEec54D7CG_jsgsfB4lkM3sxDPyxXxSSOuBtTv9TJ6UO0Y_UywdGmHqDn66uny9vq_uHm7vLivjK8kbmqjaa2o1QTYMby8mstaqaJZKwB21ptZ6aWhHPDqZ3BlFgNkrQt14JaOe34ATpd-_YxvA6QslqEIZZHk2I1Y7yZckaKiq1VJoaUIljVR7cqgRUl6gu2WsNWJYD6hq3GsnSysR5mheDvyg_dIuBrQSoj_wLx7_Y_tp8LXI5M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2622379320</pqid></control><display><type>article</type><title>Presumed adrenal insufficiency in neonates treated with corticosteroids for the prevention of bronchopulmonary dysplasia</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Josephsen, Justin B. ; Hemmann, Brianna M. ; Anderson, Connie D. ; Hemmann, Brett M. ; Buchanan, Paula M. ; Williams, Howard L. ; Lubsch, Lisa M. ; Hillman, Noah H.</creator><creatorcontrib>Josephsen, Justin B. ; Hemmann, Brianna M. ; Anderson, Connie D. ; Hemmann, Brett M. ; Buchanan, Paula M. ; Williams, Howard L. ; Lubsch, Lisa M. ; Hillman, Noah H.</creatorcontrib><description>Objective
To determine if extremely preterm (EPT) neonates receiving dexamethasone for the prevention of BPD have a higher incidence of presumed adrenal insufficiency (PAI).
Study design
Retrospective cohort study of neonates <28 weeks gestation examining PAI after dexamethasone use and PAI after intratracheal budesonide with surfactant administration.
Result
Of 332 neonates, 38% received dexamethasone. The incidence of PAI was higher in neonates who had received dexamethasone (20.8% vs 2.9%,
p
< 0.001). However, for intubated babies receiving surfactant, dexamethasone was not independently associated with increased PAI after adjusting for gestational age, birthweight, and race (aOR 2.92, 95% CI: 0.79–10.85). Dexamethasone was independently associated with increased PAI in infants previously receiving budesonide/surfactant treatment (aOR 5.38, 95% CI: 1.38–20.90).
Conclusion
The use of dexamethasone alone was not associated with increased PAI, when adjusted for prematurity-related factors. The combination of budesonide with dexamethasone was significantly associated with increased PAI.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-021-01251-y</identifier><identifier>PMID: 34725449</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/163 ; 692/700/1720 ; Adrenal Cortex Hormones - therapeutic use ; Adrenal Insufficiency - chemically induced ; Adrenal Insufficiency - epidemiology ; Adrenal Insufficiency - prevention & control ; Birth weight ; Bronchopulmonary Dysplasia - etiology ; Budesonide ; Budesonide - adverse effects ; Corticoids ; Corticosteroids ; Dexamethasone ; Dexamethasone - adverse effects ; Dysplasia ; Gestational age ; Humans ; Immunomodulators ; Infant ; Infant, Newborn ; Lung diseases ; Medicine ; Medicine & Public Health ; Neonates ; Newborn babies ; Pediatric Surgery ; Pediatrics ; Prevention ; Pulmonary Surfactants - therapeutic use ; Respiration, Artificial - adverse effects ; Retrospective Studies ; Surface-Active Agents - therapeutic use ; Surfactants ; Trachea</subject><ispartof>Journal of perinatology, 2022-01, Vol.42 (1), p.65-71</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-6ca1fd11a0e2cf30216462a05227ef8fafbc65033c31fbe90fae50883a41f59d3</citedby><cites>FETCH-LOGICAL-c375t-6ca1fd11a0e2cf30216462a05227ef8fafbc65033c31fbe90fae50883a41f59d3</cites><orcidid>0000-0003-4175-7977</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41372-021-01251-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41372-021-01251-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34725449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Josephsen, Justin B.</creatorcontrib><creatorcontrib>Hemmann, Brianna M.</creatorcontrib><creatorcontrib>Anderson, Connie D.</creatorcontrib><creatorcontrib>Hemmann, Brett M.</creatorcontrib><creatorcontrib>Buchanan, Paula M.</creatorcontrib><creatorcontrib>Williams, Howard L.</creatorcontrib><creatorcontrib>Lubsch, Lisa M.</creatorcontrib><creatorcontrib>Hillman, Noah H.</creatorcontrib><title>Presumed adrenal insufficiency in neonates treated with corticosteroids for the prevention of bronchopulmonary dysplasia</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
To determine if extremely preterm (EPT) neonates receiving dexamethasone for the prevention of BPD have a higher incidence of presumed adrenal insufficiency (PAI).
Study design
Retrospective cohort study of neonates <28 weeks gestation examining PAI after dexamethasone use and PAI after intratracheal budesonide with surfactant administration.
Result
Of 332 neonates, 38% received dexamethasone. The incidence of PAI was higher in neonates who had received dexamethasone (20.8% vs 2.9%,
p
< 0.001). However, for intubated babies receiving surfactant, dexamethasone was not independently associated with increased PAI after adjusting for gestational age, birthweight, and race (aOR 2.92, 95% CI: 0.79–10.85). Dexamethasone was independently associated with increased PAI in infants previously receiving budesonide/surfactant treatment (aOR 5.38, 95% CI: 1.38–20.90).
Conclusion
The use of dexamethasone alone was not associated with increased PAI, when adjusted for prematurity-related factors. The combination of budesonide with dexamethasone was significantly associated with increased PAI.</description><subject>692/163</subject><subject>692/700/1720</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Adrenal Insufficiency - chemically induced</subject><subject>Adrenal Insufficiency - epidemiology</subject><subject>Adrenal Insufficiency - prevention & control</subject><subject>Birth weight</subject><subject>Bronchopulmonary Dysplasia - etiology</subject><subject>Budesonide</subject><subject>Budesonide - adverse effects</subject><subject>Corticoids</subject><subject>Corticosteroids</subject><subject>Dexamethasone</subject><subject>Dexamethasone - adverse effects</subject><subject>Dysplasia</subject><subject>Gestational age</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Lung diseases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Prevention</subject><subject>Pulmonary Surfactants - therapeutic use</subject><subject>Respiration, Artificial - adverse effects</subject><subject>Retrospective Studies</subject><subject>Surface-Active Agents - therapeutic use</subject><subject>Surfactants</subject><subject>Trachea</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kMtOwzAQRS0EgvL4ARbIEuuAn0m6RIiXhAQLWFuuM6auWjvYDpC_x9ACO1aj0dy5c-cgdEzJGSW8PU-C8oZVhNGKUCZpNW6hCRVNXUkp-DaakEbwquWi3kP7KS0I-Ro2u2iPi4ZJIaYT9PEYIQ0r6LDuIni9xM6nwVpnHHgzlg57CF5nSDhHKLXD7y7PsQkxOxNShhhcl7ANEec54D7CG_jsgsfB4lkM3sxDPyxXxSSOuBtTv9TJ6UO0Y_UywdGmHqDn66uny9vq_uHm7vLivjK8kbmqjaa2o1QTYMby8mstaqaJZKwB21ptZ6aWhHPDqZ3BlFgNkrQt14JaOe34ATpd-_YxvA6QslqEIZZHk2I1Y7yZckaKiq1VJoaUIljVR7cqgRUl6gu2WsNWJYD6hq3GsnSysR5mheDvyg_dIuBrQSoj_wLx7_Y_tp8LXI5M</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Josephsen, Justin B.</creator><creator>Hemmann, Brianna M.</creator><creator>Anderson, Connie D.</creator><creator>Hemmann, Brett M.</creator><creator>Buchanan, Paula M.</creator><creator>Williams, Howard L.</creator><creator>Lubsch, Lisa M.</creator><creator>Hillman, Noah H.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-4175-7977</orcidid></search><sort><creationdate>20220101</creationdate><title>Presumed adrenal insufficiency in neonates treated with corticosteroids for the prevention of bronchopulmonary dysplasia</title><author>Josephsen, Justin B. ; Hemmann, Brianna M. ; Anderson, Connie D. ; Hemmann, Brett M. ; Buchanan, Paula M. ; Williams, Howard L. ; Lubsch, Lisa M. ; Hillman, Noah H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-6ca1fd11a0e2cf30216462a05227ef8fafbc65033c31fbe90fae50883a41f59d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>692/163</topic><topic>692/700/1720</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Adrenal Insufficiency - chemically induced</topic><topic>Adrenal Insufficiency - epidemiology</topic><topic>Adrenal Insufficiency - prevention & control</topic><topic>Birth weight</topic><topic>Bronchopulmonary Dysplasia - etiology</topic><topic>Budesonide</topic><topic>Budesonide - adverse effects</topic><topic>Corticoids</topic><topic>Corticosteroids</topic><topic>Dexamethasone</topic><topic>Dexamethasone - adverse effects</topic><topic>Dysplasia</topic><topic>Gestational age</topic><topic>Humans</topic><topic>Immunomodulators</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Lung diseases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Prevention</topic><topic>Pulmonary Surfactants - therapeutic use</topic><topic>Respiration, Artificial - adverse effects</topic><topic>Retrospective Studies</topic><topic>Surface-Active Agents - therapeutic use</topic><topic>Surfactants</topic><topic>Trachea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Josephsen, Justin B.</creatorcontrib><creatorcontrib>Hemmann, Brianna M.</creatorcontrib><creatorcontrib>Anderson, Connie D.</creatorcontrib><creatorcontrib>Hemmann, Brett M.</creatorcontrib><creatorcontrib>Buchanan, Paula M.</creatorcontrib><creatorcontrib>Williams, Howard L.</creatorcontrib><creatorcontrib>Lubsch, Lisa M.</creatorcontrib><creatorcontrib>Hillman, Noah H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Josephsen, Justin B.</au><au>Hemmann, Brianna M.</au><au>Anderson, Connie D.</au><au>Hemmann, Brett M.</au><au>Buchanan, Paula M.</au><au>Williams, Howard L.</au><au>Lubsch, Lisa M.</au><au>Hillman, Noah H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presumed adrenal insufficiency in neonates treated with corticosteroids for the prevention of bronchopulmonary dysplasia</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>42</volume><issue>1</issue><spage>65</spage><epage>71</epage><pages>65-71</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective
To determine if extremely preterm (EPT) neonates receiving dexamethasone for the prevention of BPD have a higher incidence of presumed adrenal insufficiency (PAI).
Study design
Retrospective cohort study of neonates <28 weeks gestation examining PAI after dexamethasone use and PAI after intratracheal budesonide with surfactant administration.
Result
Of 332 neonates, 38% received dexamethasone. The incidence of PAI was higher in neonates who had received dexamethasone (20.8% vs 2.9%,
p
< 0.001). However, for intubated babies receiving surfactant, dexamethasone was not independently associated with increased PAI after adjusting for gestational age, birthweight, and race (aOR 2.92, 95% CI: 0.79–10.85). Dexamethasone was independently associated with increased PAI in infants previously receiving budesonide/surfactant treatment (aOR 5.38, 95% CI: 1.38–20.90).
Conclusion
The use of dexamethasone alone was not associated with increased PAI, when adjusted for prematurity-related factors. The combination of budesonide with dexamethasone was significantly associated with increased PAI.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>34725449</pmid><doi>10.1038/s41372-021-01251-y</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4175-7977</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2022-01, Vol.42 (1), p.65-71 |
| issn | 0743-8346 1476-5543 |
| language | eng |
| recordid | cdi_proquest_journals_2622379320 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | 692/163 692/700/1720 Adrenal Cortex Hormones - therapeutic use Adrenal Insufficiency - chemically induced Adrenal Insufficiency - epidemiology Adrenal Insufficiency - prevention & control Birth weight Bronchopulmonary Dysplasia - etiology Budesonide Budesonide - adverse effects Corticoids Corticosteroids Dexamethasone Dexamethasone - adverse effects Dysplasia Gestational age Humans Immunomodulators Infant Infant, Newborn Lung diseases Medicine Medicine & Public Health Neonates Newborn babies Pediatric Surgery Pediatrics Prevention Pulmonary Surfactants - therapeutic use Respiration, Artificial - adverse effects Retrospective Studies Surface-Active Agents - therapeutic use Surfactants Trachea |
| title | Presumed adrenal insufficiency in neonates treated with corticosteroids for the prevention of bronchopulmonary dysplasia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T11%3A40%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Presumed%20adrenal%20insufficiency%20in%20neonates%20treated%20with%20corticosteroids%20for%20the%20prevention%20of%20bronchopulmonary%20dysplasia&rft.jtitle=Journal%20of%20perinatology&rft.au=Josephsen,%20Justin%20B.&rft.date=2022-01-01&rft.volume=42&rft.issue=1&rft.spage=65&rft.epage=71&rft.pages=65-71&rft.issn=0743-8346&rft.eissn=1476-5543&rft_id=info:doi/10.1038/s41372-021-01251-y&rft_dat=%3Cproquest_cross%3E2622379320%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2622379320&rft_id=info:pmid/34725449&rfr_iscdi=true |