DNA binding graphene quantum dots inhibit dual topoisomerases for cancer chemotherapy

DNA-protein interfacial inhibition is a classical paradigm for design of diverse interfacial inhibitors as clinically relevant anticancer drugs. To extend this paradigm from small molecules to nanoparticles, we synthesized pyridine N-modified polycationic graphene quantum dots (Graphenin) as a new c...

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Veröffentlicht in:	Carbon (New York) 2022-02, Vol.187, p.365-374
Hauptverfasser:	Geng, Bijiang, Hu, Jinyan, Li, Ping, Pan, Dengyu, Shen, Longxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer drugs Apoptosis Binding Cancer Chemical synthesis Chemotherapy Deoxyribonucleic acid DNA DNA major groove Graphene Graphene quantum dots Grooves Inhibitors Interfacial inhibition Nanoparticles Proteins Quantum dots Topoisomerase I and II
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