Nanomedicine Based on Natural Products: Improving Clinical Application Potential
Natural products have antitumor, anti-inflammatory, antioxidant, and other pharmacological activities and are an important source of drugs for prevention and treatment of various diseases. However, the inherent defects of natural products in physiological media such as poor solubility and stability...
Gespeichert in:
| Veröffentlicht in: | Journal of nanomaterials 2022, Vol.2022 (1) |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | |
| container_title | Journal of nanomaterials |
| container_volume | 2022 |
| creator | Li, Zhe Zhao, Tingting Li, Jiaxin Yu, Qingying Feng, Yu Xie, Yicheng Sun, Peng |
| description | Natural products have antitumor, anti-inflammatory, antioxidant, and other pharmacological activities and are an important source of drugs for prevention and treatment of various diseases. However, the inherent defects of natural products in physiological media such as poor solubility and stability and short biological half-life limit their clinical application. In recent years, more and more attention has been paid to the science of drug delivery by nanoscale materials. A large number of in vitro and in vivo studies have further confirmed the efficacy and safety of nanomedicine based on natural products in preclinical models of various diseases. In this review, we summarized the achievements of nanomaterials in improving the efficacy of natural products, introduced the research progress in several key fields of natural product-based nanomedicine in medical application, and discussed the challenges and prospects of clinical transformation of nanomedicine. |
| doi_str_mv | 10.1155/2022/3066613 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2622087109</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2622087109</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-688ebfc829b8e8bb8839ee2667a3d6394dd84b90dc19fd142b83dc79dd1221423</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EEqWw4wMisYRQPxLHZlciHpWq0gWsLcd2wFVqBzsB8fe4asWS1dzRnJk7ugBcIniLUFnOMMR4RiClFJEjMEGUVXmBMD_-0wiegrMYNxAWJS_xBKxX0vmt0VZZZ7J7GY3OvMtWchiD7LJ18HpUQ7zLFts--C_r3rO6s86qNJz3fZfEYNPC2g_GDVZ25-CklV00F4c6BW-PD6_1c758eVrU82WuCKmGnDJmmlYxzBtmWNMwRrgxmNJKEk0JL7RmRcOhVoi3GhW4YUSrimuNME4tmYKr_d301udo4iA2fgwuWQpMMYasQpAn6mZPqeBjDKYVfbBbGX4EgmKXmdhlJg6ZJfx6j39Yp-W3_Z_-Bdbnav4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2622087109</pqid></control><display><type>article</type><title>Nanomedicine Based on Natural Products: Improving Clinical Application Potential</title><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Li, Zhe ; Zhao, Tingting ; Li, Jiaxin ; Yu, Qingying ; Feng, Yu ; Xie, Yicheng ; Sun, Peng</creator><contributor>Wang, Ruibing ; Ruibing Wang</contributor><creatorcontrib>Li, Zhe ; Zhao, Tingting ; Li, Jiaxin ; Yu, Qingying ; Feng, Yu ; Xie, Yicheng ; Sun, Peng ; Wang, Ruibing ; Ruibing Wang</creatorcontrib><description>Natural products have antitumor, anti-inflammatory, antioxidant, and other pharmacological activities and are an important source of drugs for prevention and treatment of various diseases. However, the inherent defects of natural products in physiological media such as poor solubility and stability and short biological half-life limit their clinical application. In recent years, more and more attention has been paid to the science of drug delivery by nanoscale materials. A large number of in vitro and in vivo studies have further confirmed the efficacy and safety of nanomedicine based on natural products in preclinical models of various diseases. In this review, we summarized the achievements of nanomaterials in improving the efficacy of natural products, introduced the research progress in several key fields of natural product-based nanomedicine in medical application, and discussed the challenges and prospects of clinical transformation of nanomedicine.</description><identifier>ISSN: 1687-4110</identifier><identifier>EISSN: 1687-4129</identifier><identifier>DOI: 10.1155/2022/3066613</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Antioxidants ; Bioavailability ; Cancer therapies ; Chemotherapy ; Chronic illnesses ; Diabetes ; Disease ; Drug delivery systems ; Drug dosages ; Drug resistance ; In vivo methods and tests ; Leukemia ; Medical research ; Metabolism ; Microorganisms ; Nanomaterials ; Nanoparticles ; Nanotechnology ; Natural products ; Permeability ; Product safety ; Signal transduction</subject><ispartof>Journal of nanomaterials, 2022, Vol.2022 (1)</ispartof><rights>Copyright © 2022 Zhe Li et al.</rights><rights>Copyright © 2022 Zhe Li et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-688ebfc829b8e8bb8839ee2667a3d6394dd84b90dc19fd142b83dc79dd1221423</citedby><cites>FETCH-LOGICAL-c337t-688ebfc829b8e8bb8839ee2667a3d6394dd84b90dc19fd142b83dc79dd1221423</cites><orcidid>0000-0003-4117-4165</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27928,27929,27930</link.rule.ids></links><search><contributor>Wang, Ruibing</contributor><contributor>Ruibing Wang</contributor><creatorcontrib>Li, Zhe</creatorcontrib><creatorcontrib>Zhao, Tingting</creatorcontrib><creatorcontrib>Li, Jiaxin</creatorcontrib><creatorcontrib>Yu, Qingying</creatorcontrib><creatorcontrib>Feng, Yu</creatorcontrib><creatorcontrib>Xie, Yicheng</creatorcontrib><creatorcontrib>Sun, Peng</creatorcontrib><title>Nanomedicine Based on Natural Products: Improving Clinical Application Potential</title><title>Journal of nanomaterials</title><description>Natural products have antitumor, anti-inflammatory, antioxidant, and other pharmacological activities and are an important source of drugs for prevention and treatment of various diseases. However, the inherent defects of natural products in physiological media such as poor solubility and stability and short biological half-life limit their clinical application. In recent years, more and more attention has been paid to the science of drug delivery by nanoscale materials. A large number of in vitro and in vivo studies have further confirmed the efficacy and safety of nanomedicine based on natural products in preclinical models of various diseases. In this review, we summarized the achievements of nanomaterials in improving the efficacy of natural products, introduced the research progress in several key fields of natural product-based nanomedicine in medical application, and discussed the challenges and prospects of clinical transformation of nanomedicine.</description><subject>Antioxidants</subject><subject>Bioavailability</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Chronic illnesses</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Drug delivery systems</subject><subject>Drug dosages</subject><subject>Drug resistance</subject><subject>In vivo methods and tests</subject><subject>Leukemia</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Microorganisms</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Natural products</subject><subject>Permeability</subject><subject>Product safety</subject><subject>Signal transduction</subject><issn>1687-4110</issn><issn>1687-4129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kMtOwzAQRS0EEqWw4wMisYRQPxLHZlciHpWq0gWsLcd2wFVqBzsB8fe4asWS1dzRnJk7ugBcIniLUFnOMMR4RiClFJEjMEGUVXmBMD_-0wiegrMYNxAWJS_xBKxX0vmt0VZZZ7J7GY3OvMtWchiD7LJ18HpUQ7zLFts--C_r3rO6s86qNJz3fZfEYNPC2g_GDVZ25-CklV00F4c6BW-PD6_1c758eVrU82WuCKmGnDJmmlYxzBtmWNMwRrgxmNJKEk0JL7RmRcOhVoi3GhW4YUSrimuNME4tmYKr_d301udo4iA2fgwuWQpMMYasQpAn6mZPqeBjDKYVfbBbGX4EgmKXmdhlJg6ZJfx6j39Yp-W3_Z_-Bdbnav4</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Li, Zhe</creator><creator>Zhao, Tingting</creator><creator>Li, Jiaxin</creator><creator>Yu, Qingying</creator><creator>Feng, Yu</creator><creator>Xie, Yicheng</creator><creator>Sun, Peng</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>L7M</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-4117-4165</orcidid></search><sort><creationdate>2022</creationdate><title>Nanomedicine Based on Natural Products: Improving Clinical Application Potential</title><author>Li, Zhe ; Zhao, Tingting ; Li, Jiaxin ; Yu, Qingying ; Feng, Yu ; Xie, Yicheng ; Sun, Peng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-688ebfc829b8e8bb8839ee2667a3d6394dd84b90dc19fd142b83dc79dd1221423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antioxidants</topic><topic>Bioavailability</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Chronic illnesses</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Drug delivery systems</topic><topic>Drug dosages</topic><topic>Drug resistance</topic><topic>In vivo methods and tests</topic><topic>Leukemia</topic><topic>Medical research</topic><topic>Metabolism</topic><topic>Microorganisms</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Natural products</topic><topic>Permeability</topic><topic>Product safety</topic><topic>Signal transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhe</creatorcontrib><creatorcontrib>Zhao, Tingting</creatorcontrib><creatorcontrib>Li, Jiaxin</creatorcontrib><creatorcontrib>Yu, Qingying</creatorcontrib><creatorcontrib>Feng, Yu</creatorcontrib><creatorcontrib>Xie, Yicheng</creatorcontrib><creatorcontrib>Sun, Peng</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of nanomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhe</au><au>Zhao, Tingting</au><au>Li, Jiaxin</au><au>Yu, Qingying</au><au>Feng, Yu</au><au>Xie, Yicheng</au><au>Sun, Peng</au><au>Wang, Ruibing</au><au>Ruibing Wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nanomedicine Based on Natural Products: Improving Clinical Application Potential</atitle><jtitle>Journal of nanomaterials</jtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><issue>1</issue><issn>1687-4110</issn><eissn>1687-4129</eissn><abstract>Natural products have antitumor, anti-inflammatory, antioxidant, and other pharmacological activities and are an important source of drugs for prevention and treatment of various diseases. However, the inherent defects of natural products in physiological media such as poor solubility and stability and short biological half-life limit their clinical application. In recent years, more and more attention has been paid to the science of drug delivery by nanoscale materials. A large number of in vitro and in vivo studies have further confirmed the efficacy and safety of nanomedicine based on natural products in preclinical models of various diseases. In this review, we summarized the achievements of nanomaterials in improving the efficacy of natural products, introduced the research progress in several key fields of natural product-based nanomedicine in medical application, and discussed the challenges and prospects of clinical transformation of nanomedicine.</abstract><cop>New York</cop><pub>Hindawi</pub><doi>10.1155/2022/3066613</doi><orcidid>https://orcid.org/0000-0003-4117-4165</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1687-4110 |
| ispartof | Journal of nanomaterials, 2022, Vol.2022 (1) |
| issn | 1687-4110 1687-4129 |
| language | eng |
| recordid | cdi_proquest_journals_2622087109 |
| source | EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Antioxidants Bioavailability Cancer therapies Chemotherapy Chronic illnesses Diabetes Disease Drug delivery systems Drug dosages Drug resistance In vivo methods and tests Leukemia Medical research Metabolism Microorganisms Nanomaterials Nanoparticles Nanotechnology Natural products Permeability Product safety Signal transduction |
| title | Nanomedicine Based on Natural Products: Improving Clinical Application Potential |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T14%3A55%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nanomedicine%20Based%20on%20Natural%20Products:%20Improving%20Clinical%20Application%20Potential&rft.jtitle=Journal%20of%20nanomaterials&rft.au=Li,%20Zhe&rft.date=2022&rft.volume=2022&rft.issue=1&rft.issn=1687-4110&rft.eissn=1687-4129&rft_id=info:doi/10.1155/2022/3066613&rft_dat=%3Cproquest_cross%3E2622087109%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2622087109&rft_id=info:pmid/&rfr_iscdi=true |