Efficient Site‐Selective Immobilization of Aldehyde‐Tagged Peptides and Proteins by Knoevenagel Ligation

The aldehyde tag is appropriate to selectively label proteins, prepare antibody‐drug conjugates or to immobilize enzymes or antibodies for biotechnological and medical applications. The cysteine within the consensus sequence CxPxR of the aldehyde tag is specifically oxidized by the formylglycine‐gen...

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Veröffentlicht in:	ChemCatChem 2022-01, Vol.14 (2), p.n/a
Hauptverfasser:	Janson, Nils, Heinks, Tobias, Beuel, Tobias, Alam, Sarfaraz, Höhne, Matthias, Bornscheuer, Uwe T., Fischer von Mollard, Gabriele, Sewald, Norbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Amino acids Antibodies biocatalysis Enzymes formylglycine-generating enzyme Immobilization Knoevenagel ligation Peptides protein engineering Proteins Reagents transaminase
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