Asymmetric Synthesis of N‐Substituted γ‐Amino Esters and γ‐Lactams Containing α,γ‐Stereogenic Centers via a Stereoselective Enzymatic Cascade

γ‐Amino esters and γ‐lactams containing α,γ‐stereogenic centers are widely used as chiral intermediates in various bioactive compounds, while their efficient synthesis remains a challenge. Herein, an enzymatic cascade reaction involving an ene reductase (ERED) and an imine reductase (IRED) for acces...

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Veröffentlicht in:	Advanced synthesis & catalysis 2022-01, Vol.364 (2), p.372-379
Hauptverfasser:	Li, Ming, Cui, Yunfeng, Xu, Zefei, Chen, Xi, Feng, Jinhui, Wang, Min, Yao, Peiyuan, Wu, Qiaqing, Zhu, Dunming
Format:	Artikel
Sprache:	eng
Schlagworte:	Cascade chemical reactions cascade reaction Cyclohexane Esters imine reductases Organic compounds Reductases Stereoisomerism Stereoselectivity γ-Amino esters γ-lactams ene reductases
Online-Zugang:	Volltext
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