2-Pyridinylmethyl borrowing: base-promoted C -alkylation of (pyridin-2-yl)-methyl alcohols with ketones via cleavage of unstrained C(sp 3 )–C(sp 3 ) bonds

A transition metal-free synthesis of β-(pyridin-2-yl)-methyl ketones, using (pyridin-2-yl)methyl alcohols and ketones through the 2-pyridinylmethyl borrowing strategy, has been disclosed. This approach provides an efficient, available and environmentally benign access, leading to alkylation products...

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Veröffentlicht in:	Organic Chemistry Frontiers 2022-01, Vol.9 (2), p.299-304
Hauptverfasser:	Hong, Chuan-Ming, Zou, Fei-Fei, Zhuang, Xin, Luo, Zhen, Liu, Zheng-Qiang, Ren, Li-Qing, Li, Qing-Hua, Liu, Tang-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohols Alkylation Atom economy Cleavage Ductile-brittle transition Functional groups Ketones Organic chemistry Transition metals
Online-Zugang:	Volltext
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