Synthesis of the C50 diastereomers of the C33–C51 fragment of stambomycin D
As products of genome mining, the stereochemical assignment of the macrolide antibiotics stambomycins A–D has been made on the basis of sequence analysis of the associated polyketide synthase, aside from two stereocentres at C28 and C50. Here we describe syntheses of the two C50 diastereomers of the...
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| Veröffentlicht in: | Organic Chemistry Frontiers 2022-01, Vol.9 (2), p.445-449 |
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| creator | Wang, Yongchen Chintalapudi, Venkaiah Gudmundsson, Haraldur G. Challis, Gregory L. Anderson, Edward A. |
| description | As products of genome mining, the stereochemical assignment of the macrolide antibiotics stambomycins A–D has been made on the basis of sequence analysis of the associated polyketide synthase, aside from two stereocentres at C28 and C50. Here we describe syntheses of the two C50 diastereomers of the C33–C51 region of the stambomycins, which support the PKS-based configurational assignment, and establish a strategy suitable for access to the extended stambomycin framework. |
| doi_str_mv | 10.1039/D1QO01635K |
| format | Article |
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| identifier | ISSN: 2052-4129 |
| ispartof | Organic Chemistry Frontiers, 2022-01, Vol.9 (2), p.445-449 |
| issn | 2052-4129 2052-4110 2052-4129 2052-4110 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Antibiotics Diastereoisomers Genomes Macrolide antibiotics Organic chemistry Polyketide synthase Sequence analysis |
| title | Synthesis of the C50 diastereomers of the C33–C51 fragment of stambomycin D |
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