Different drug-processing enzymes with atropineand cocainesterase activities reported in rabbits and humans
The genetic system involved in atropine and cocaine metabolism in rabbits is different from that implied in humans. In a very simple configuration, two linked autosomal genes located on rabbit chromosome 5 are involved in those two drugs metabolism in this species. A specific atropinesterase activit...
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| Veröffentlicht in: | Rabbit genetics 2021-12, Vol.11 (1), p.10-15 |
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| creator | Grădinaru, Andrei C |
| description | The genetic system involved in atropine and cocaine metabolism in rabbits is different from that implied in humans. In a very simple configuration, two linked autosomal genes located on rabbit chromosome 5 are involved in those two drugs metabolism in this species. A specific atropinesterase activity is missing in humans, but a more complicated cocainesterase activity was reported. Two autosomal genes, hCE-1 and hCE-2, are mainly involved in the metabolism of various esters of cocaine. A butyrylcholinesterase, whose gene is located on human chromosome 3, was also reported in this regard. This review aimed at comprehensively assessing and discussing the atropinesterase and cocainesterase activities in rabbits and humans, with implications in various drugs' metabolism and detoxification. |
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In a very simple configuration, two linked autosomal genes located on rabbit chromosome 5 are involved in those two drugs metabolism in this species. A specific atropinesterase activity is missing in humans, but a more complicated cocainesterase activity was reported. Two autosomal genes, hCE-1 and hCE-2, are mainly involved in the metabolism of various esters of cocaine. A butyrylcholinesterase, whose gene is located on human chromosome 3, was also reported in this regard. This review aimed at comprehensively assessing and discussing the atropinesterase and cocainesterase activities in rabbits and humans, with implications in various drugs' metabolism and detoxification.</description><identifier>ISSN: 2248-3098</identifier><language>eng</language><publisher>Cluj-Napoca: Bioflux SRL</publisher><subject>Atropine ; Chromosome 3 ; Chromosome 5 ; Chromosomes ; Cocaine ; Detoxification ; Drug metabolism ; Drugs ; Enzymes ; Esters ; Genes ; Heart rate ; Liver ; Metabolism ; Metabolites</subject><ispartof>Rabbit genetics, 2021-12, Vol.11 (1), p.10-15</ispartof><rights>Copyright Bioflux SRL Dec 2021</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Grădinaru, Andrei C</creatorcontrib><title>Different drug-processing enzymes with atropineand cocainesterase activities reported in rabbits and humans</title><title>Rabbit genetics</title><description>The genetic system involved in atropine and cocaine metabolism in rabbits is different from that implied in humans. In a very simple configuration, two linked autosomal genes located on rabbit chromosome 5 are involved in those two drugs metabolism in this species. A specific atropinesterase activity is missing in humans, but a more complicated cocainesterase activity was reported. Two autosomal genes, hCE-1 and hCE-2, are mainly involved in the metabolism of various esters of cocaine. A butyrylcholinesterase, whose gene is located on human chromosome 3, was also reported in this regard. This review aimed at comprehensively assessing and discussing the atropinesterase and cocainesterase activities in rabbits and humans, with implications in various drugs' metabolism and detoxification.</description><subject>Atropine</subject><subject>Chromosome 3</subject><subject>Chromosome 5</subject><subject>Chromosomes</subject><subject>Cocaine</subject><subject>Detoxification</subject><subject>Drug metabolism</subject><subject>Drugs</subject><subject>Enzymes</subject><subject>Esters</subject><subject>Genes</subject><subject>Heart rate</subject><subject>Liver</subject><subject>Metabolism</subject><subject>Metabolites</subject><issn>2248-3098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNjUsKwkAQRGehYNDcocF1YDJJJK794AHchzHpaPuZid0TRU9vBA_gqgrqVdVIRcbkZZLpZTlRschZa52mpjDZMlKXNbUtMroADffHpGNfowi5I6B7v24o8KRwAhvYd-TQugZqX9vBSkC2gmDrQA8KNKCMneeADZADtocDBYFv49TfrJOZGrf2Khj_dKrm281-tfue3vthrzr7nt0QVWZhtDaLssiz_6gPQP9Kiw</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Grădinaru, Andrei C</creator><general>Bioflux SRL</general><scope>8FE</scope><scope>8FH</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20211201</creationdate><title>Different drug-processing enzymes with atropineand cocainesterase activities reported in rabbits and humans</title><author>Grădinaru, Andrei C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_26200268543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Atropine</topic><topic>Chromosome 3</topic><topic>Chromosome 5</topic><topic>Chromosomes</topic><topic>Cocaine</topic><topic>Detoxification</topic><topic>Drug metabolism</topic><topic>Drugs</topic><topic>Enzymes</topic><topic>Esters</topic><topic>Genes</topic><topic>Heart rate</topic><topic>Liver</topic><topic>Metabolism</topic><topic>Metabolites</topic><toplevel>online_resources</toplevel><creatorcontrib>Grădinaru, Andrei C</creatorcontrib><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Rabbit genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grădinaru, Andrei C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different drug-processing enzymes with atropineand cocainesterase activities reported in rabbits and humans</atitle><jtitle>Rabbit genetics</jtitle><date>2021-12-01</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>10</spage><epage>15</epage><pages>10-15</pages><issn>2248-3098</issn><abstract>The genetic system involved in atropine and cocaine metabolism in rabbits is different from that implied in humans. In a very simple configuration, two linked autosomal genes located on rabbit chromosome 5 are involved in those two drugs metabolism in this species. A specific atropinesterase activity is missing in humans, but a more complicated cocainesterase activity was reported. Two autosomal genes, hCE-1 and hCE-2, are mainly involved in the metabolism of various esters of cocaine. A butyrylcholinesterase, whose gene is located on human chromosome 3, was also reported in this regard. This review aimed at comprehensively assessing and discussing the atropinesterase and cocainesterase activities in rabbits and humans, with implications in various drugs' metabolism and detoxification.</abstract><cop>Cluj-Napoca</cop><pub>Bioflux SRL</pub></addata></record> |
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| identifier | ISSN: 2248-3098 |
| ispartof | Rabbit genetics, 2021-12, Vol.11 (1), p.10-15 |
| issn | 2248-3098 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Atropine Chromosome 3 Chromosome 5 Chromosomes Cocaine Detoxification Drug metabolism Drugs Enzymes Esters Genes Heart rate Liver Metabolism Metabolites |
| title | Different drug-processing enzymes with atropineand cocainesterase activities reported in rabbits and humans |
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