Convergent synthesis, drug target prediction, and docking studies of new 2,6,9‐trisubstituted purine derivatives

A set of new 2,6,9‐trisubstituted purine derivatives were designed and synthesized from 6‐chloro‐2‐fluoro‐9‐alkyl‐9H‐purine as the key starting material. These purines were synthesized via a multistep protocol and finally subjected to SNAr with various aminopiperidinyl salts. The structures of these...

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Veröffentlicht in:	Journal of heterocyclic chemistry 2022-01, Vol.59 (1), p.97-111
Hauptverfasser:	Villegas, Alondra, Satheeshkumar, Rajendran, Ballesteros‐Casallas, Andrés, Paulino, Margot, Castro, Alejandro, Espinosa‐Bustos, Christian, Salas, Cristian O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Docking Kinases Ligands NMR Nuclear magnetic resonance Proteins Purines Spectral methods Synthesis
Online-Zugang:	Volltext
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