Cardiovascular Events and Mortality in Patients Undergoing Adjuvant Radiotherapy for Breast Cancer: a Systematic Review
Objective We performed a systematic review to quantify the cardiovascular risk of adjuvant radiotherapy (RT) for breast cancer. Methods A literature search was conducted using MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from inception to July 2020. Results The literature...
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| Veröffentlicht in: | Hong Kong journal of radiology : HKJR = Xianggang fang she ke yi xue za zhi 2021-09, Vol.24 (3), p.148-166 |
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| container_title | Hong Kong journal of radiology : HKJR = Xianggang fang she ke yi xue za zhi |
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| creator | Taylor, P Chan, S Wan, AB Chan, CW Rodrigues, MM Lam, H Chow, E Lim, FMY |
| description | Objective We performed a systematic review to quantify the cardiovascular risk of adjuvant radiotherapy (RT) for breast cancer. Methods A literature search was conducted using MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from inception to July 2020. Results The literature search produced 7363 reports, of which 76 met our inclusion criteria. In studies comparing left-sided RT with right-sided RT, 7 of 35 (20%) studies found increased cardiovascular mortality, and 8 of 28 (29%) studies found increased cardiovascular events. In studies comparing patients who received RT with those who did not, 7 of 26 (27%) studies found increased cardiovascular mortality, and 5 of 22 (23%) studies found increased cardiovascular events. Conclusion Most of the studies that found significant associations between laterality and cardiovascular risks included treatment periods that started prior to 1985, suggesting that modern RT techniques have minimised the cardiac exposure in breast cancer patients receiving RT. However, more focused studies must be conducted to investigate the long- term cardiovascular risk associated with modern RT techniques. |
| doi_str_mv | 10.12809/hkjr2117234 |
| format | Article |
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Methods A literature search was conducted using MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from inception to July 2020. Results The literature search produced 7363 reports, of which 76 met our inclusion criteria. In studies comparing left-sided RT with right-sided RT, 7 of 35 (20%) studies found increased cardiovascular mortality, and 8 of 28 (29%) studies found increased cardiovascular events. In studies comparing patients who received RT with those who did not, 7 of 26 (27%) studies found increased cardiovascular mortality, and 5 of 22 (23%) studies found increased cardiovascular events. Conclusion Most of the studies that found significant associations between laterality and cardiovascular risks included treatment periods that started prior to 1985, suggesting that modern RT techniques have minimised the cardiac exposure in breast cancer patients receiving RT. However, more focused studies must be conducted to investigate the long- term cardiovascular risk associated with modern RT techniques.</description><identifier>ISSN: 2223-6619</identifier><identifier>EISSN: 2307-4620</identifier><identifier>DOI: 10.12809/hkjr2117234</identifier><language>eng</language><publisher>Hong Kong: Hong Kong Academy of Medicine</publisher><subject>Angina pectoris ; Breast cancer ; Cardiovascular disease ; Coronary vessels ; Heart ; Lumpectomy ; Mortality ; Radiation therapy ; Systematic review</subject><ispartof>Hong Kong journal of radiology : HKJR = Xianggang fang she ke yi xue za zhi, 2021-09, Vol.24 (3), p.148-166</ispartof><rights>2021. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,27905,27906</link.rule.ids></links><search><creatorcontrib>Taylor, P</creatorcontrib><creatorcontrib>Chan, S</creatorcontrib><creatorcontrib>Wan, AB</creatorcontrib><creatorcontrib>Chan, CW</creatorcontrib><creatorcontrib>Rodrigues, MM</creatorcontrib><creatorcontrib>Lam, H</creatorcontrib><creatorcontrib>Chow, E</creatorcontrib><creatorcontrib>Lim, FMY</creatorcontrib><title>Cardiovascular Events and Mortality in Patients Undergoing Adjuvant Radiotherapy for Breast Cancer: a Systematic Review</title><title>Hong Kong journal of radiology : HKJR = Xianggang fang she ke yi xue za zhi</title><description>Objective We performed a systematic review to quantify the cardiovascular risk of adjuvant radiotherapy (RT) for breast cancer. Methods A literature search was conducted using MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from inception to July 2020. Results The literature search produced 7363 reports, of which 76 met our inclusion criteria. In studies comparing left-sided RT with right-sided RT, 7 of 35 (20%) studies found increased cardiovascular mortality, and 8 of 28 (29%) studies found increased cardiovascular events. In studies comparing patients who received RT with those who did not, 7 of 26 (27%) studies found increased cardiovascular mortality, and 5 of 22 (23%) studies found increased cardiovascular events. Conclusion Most of the studies that found significant associations between laterality and cardiovascular risks included treatment periods that started prior to 1985, suggesting that modern RT techniques have minimised the cardiac exposure in breast cancer patients receiving RT. However, more focused studies must be conducted to investigate the long- term cardiovascular risk associated with modern RT techniques.</description><subject>Angina pectoris</subject><subject>Breast cancer</subject><subject>Cardiovascular disease</subject><subject>Coronary vessels</subject><subject>Heart</subject><subject>Lumpectomy</subject><subject>Mortality</subject><subject>Radiation therapy</subject><subject>Systematic review</subject><issn>2223-6619</issn><issn>2307-4620</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpNkF1LwzAUhoMoOObu_AEBb60m6Uca7-aYHzBRprsup-np1rqlM0k7-u8tmxdenRfOy_PCQ8g1Z3dcpEzdb75rKziXIozOyEiETAZRItj5kIUIgyTh6pJMnKsZY0KqiHE5IocZ2KJqOnC63YKl8w6NdxRMQd8a62Fb-Z5Whn6Ar46flSnQrpvKrOm0qNsOjKdLGBB-gxb2PS0bSx8tgvN0BkajfaBAP3vncTcwNF1iV-HhilyUsHU4-btjsnqaf81egsX78-tsugi0iFMfQKFTHgNPUaOMk5yXSapyiVrxvBRloUOpYuQYSV4qSEOWlJgjsijRaSqVCsfk5sTd2-anReezummtGSYzMQiJZSS4GFq3p5a2jXMWy2xvqx3YPuMsO9rN_tkNfwFv729R</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Taylor, P</creator><creator>Chan, S</creator><creator>Wan, AB</creator><creator>Chan, CW</creator><creator>Rodrigues, MM</creator><creator>Lam, H</creator><creator>Chow, E</creator><creator>Lim, FMY</creator><general>Hong Kong Academy of Medicine</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20210901</creationdate><title>Cardiovascular Events and Mortality in Patients Undergoing Adjuvant Radiotherapy for Breast Cancer: a Systematic Review</title><author>Taylor, P ; 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Methods A literature search was conducted using MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from inception to July 2020. Results The literature search produced 7363 reports, of which 76 met our inclusion criteria. In studies comparing left-sided RT with right-sided RT, 7 of 35 (20%) studies found increased cardiovascular mortality, and 8 of 28 (29%) studies found increased cardiovascular events. In studies comparing patients who received RT with those who did not, 7 of 26 (27%) studies found increased cardiovascular mortality, and 5 of 22 (23%) studies found increased cardiovascular events. Conclusion Most of the studies that found significant associations between laterality and cardiovascular risks included treatment periods that started prior to 1985, suggesting that modern RT techniques have minimised the cardiac exposure in breast cancer patients receiving RT. 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| ispartof | Hong Kong journal of radiology : HKJR = Xianggang fang she ke yi xue za zhi, 2021-09, Vol.24 (3), p.148-166 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Angina pectoris Breast cancer Cardiovascular disease Coronary vessels Heart Lumpectomy Mortality Radiation therapy Systematic review |
| title | Cardiovascular Events and Mortality in Patients Undergoing Adjuvant Radiotherapy for Breast Cancer: a Systematic Review |
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