Degradation of FA reduces Aβ neurotoxicity and Alzheimer-related phenotypes

Dysregulation of formaldehyde (FA) has been implicated in the development of Alzheimer’s Disease (AD). Elevated FA levels in Alzheimer’s patients and animal models are associated with impaired cognitive functions. However, the exact role of FA in AD remains unknown. We now identified that oxidative...

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Veröffentlicht in:	Molecular psychiatry 2021-10, Vol.26 (10), p.5578-5591
Hauptverfasser:	Fei, Xuechao, Zhang, Yun, Mei, Yufei, Yue, Xiangpei, Jiang, Wenjing, Ai, Li, Yu, Yan, Luo, Hongjun, Li, Hui, Luo, Wenhong, Yang, Xu, Lyv, Jihui, He, Rongqiao, Song, Weihong, Tong, Zhiqian
Format:	Artikel
Sprache:	eng
Schlagworte:	14/3 631/337 631/378 64/110 82/51 82/58 82/80 Alzheimer Disease - genetics Alzheimer's disease Amyloid beta-Peptides Amyloid beta-Protein Precursor - genetics Animal models Animals Behavioral Sciences Beta protein Biological Psychology Coenzyme Q10 Cognitive ability Degradation Demethylation Disease Models, Animal Fibrillogenesis Formaldehyde - toxicity Formaldehyde dehydrogenase Humans Medicine Medicine & Public Health Mice Mice, Transgenic Neurodegenerative diseases Neurosciences Neurotoxicity Oligomerization Pharmacotherapy Phenotype Phenotypes Presenilin 1 Psychiatry
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