Genistein and Temozolomide-Loaded Polymeric Nanoparticles: A Synergistic Approach For Improved Anti-Tumor Efficacy Against Glioblastoma

[Display omitted] •Genistein-temozolomide nanoparticles (Gen-TMZ-NPs) decreased viability of U87MG cells.•Gen-TMZ-NP treatment decreased U87MG cell proliferation.•Migration of U87MG glioblastoma cells was strongly inhibited after 48 h Gen-TMZ-NP treatment.•mRNA levels of apoptotic genes was found to...

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Veröffentlicht in:	Process biochemistry (1991) 2021-11, Vol.110, p.9-18
Hauptverfasser:	Meteoglu, Irem, Erdemir, Aysegul
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-tumor activity Anticancer properties Antitumor agents Apoptosis Cell migration Cell proliferation Chemical properties Cytochrome Cytochrome c Cytochromes Cytotoxicity Drug delivery Dual drug delivery Genistein Glioblastoma Glioblastoma cells Glioblastoma multiforme Infrared spectroscopy Invasiveness Nanoparticles Physicochemical properties PLGA nanoparticles Polydispersity Polylactide-co-glycolide Temozolomide Toxicity Western blotting Zeta potential
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