Synthesis and antibacterial studies of azetidin-2-ones derivatives

Coupling reaction of aryldiazoniom salt of 2-aminobenzothiazole (1) and phenoxide salt of salicylaldehyde afforded azoaldehyde compound (2) which was undergone in condensation reactions with some primary anilines (3- bromoaniline, 4-aminoophenol, 3-aminophenol, 2-aminophenol, 2-methoxyaniline, 2,4-dimethylaniline and 4- acetamidoaniline), respectively using microwave irradiation technique to obtain Schiff bases (3a-g). !mine products were introduced in cyclization reaction with a-chloroacetyl chloride in dimethylformamide as solvent using microwave irradiation method to yield the target azetidin-2-one derivatives (4a-g). The evaluation of B-lactam compounds as antibacterial was taken place using two kinds of bacteria. !nhibition zone measurements pointed that azetidinone compounds (4b, 4c, 4d, 4f and 4g) have best impacts to reference antibiotic (amoxicillin-clavulanate) against both species (E. coli and Staphylococcus aurous).