Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model

Epilepsy, which is caused by abnormal neuronal firing in the brain, is a common neurological disease and affects motor and cognitive functions. Excessive levels of glutamate and insufficient levels of inhibitory GABA are involved in its pathophysiology. Valproic acid (Val), a GABAergic agonist, is o...

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Veröffentlicht in:Fundamental & clinical pharmacology 2021-12, Vol.35 (6), p.1032-1044
Hauptverfasser: Liu, Chiung‐Hui, Liao, Wen‐Chieh, Li, Hsin‐Hua, Tseng, Li‐Ho, Wang, Wei‐Han, Tung, Hsin, Lin, Pin‐Jiun, Jao, Hsin‐Tung, Liu, Wen‐Yuan, Hung, Ching‐Sui, Lin, Chih‐Li, Ho, Ying‐Jui
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Sprache:eng
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