Copper Catalyzed Synthesis of 3‐Nitro‐Quinolines from Nitro‐Olefins and Anthranils: Its Application in the Synthesis of Quindoline

Copper‐catalyzed routes have been achieved for the synthesis of 3‐nitroquinolines from readily available nitroolefins and anthranils. This reaction proceeds via the [4+2] cycloaddition between anthranils and nitro‐styrenes under mild reaction conditions to obtain biologically important heterocycles....

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Veröffentlicht in:	Advanced synthesis & catalysis 2022-01, Vol.364 (1), p.41-46
Hauptverfasser:	Awasthi, Annapurna, Yadav, Pushpendra, Yadav, Sourabh, Tiwari, Dharmendra Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	3-nitro-quinolines [4+2]-cycloaddition Alkenes anthranil Chemical synthesis Copper Cycloaddition nitro-olefines Organic compounds Styrenes
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description	Copper‐catalyzed routes have been achieved for the synthesis of 3‐nitroquinolines from readily available nitroolefins and anthranils. This reaction proceeds via the [4+2] cycloaddition between anthranils and nitro‐styrenes under mild reaction conditions to obtain biologically important heterocycles. A wide range of diversely substituted nitro‐olefins and anthranils are successfully employed in this reaction to access a series of 3‐nitro‐quinolines in 81–93% yields. The synthetic utility of the present methodology is also illustrated in this manuscript.
doi_str_mv	10.1002/adsc.202100861
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subjects	3-nitro-quinolines [4+2]-cycloaddition Alkenes anthranil Chemical synthesis Copper Cycloaddition nitro-olefines Organic compounds Styrenes
title	Copper Catalyzed Synthesis of 3‐Nitro‐Quinolines from Nitro‐Olefins and Anthranils: Its Application in the Synthesis of Quindoline
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