Carnosol attenuates bleomycin-induced lung damage via suppressing fibrosis, oxidative stress and inflammation in rats

Bleomycin, an important toxic anti-cancer agent, induces pulmonary fibrosis. The significance of oxidative stress and inflammation in promoting of bleomycin-induced idiopathic pulmonary fibrosis (IPF) has been reported. Thus, we evaluated the protective effects of carnosol as a robust natural antiox...

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Veröffentlicht in:	Life sciences (1973) 2021-12, Vol.287, p.120059, Article 120059
Hauptverfasser:	Kalantar, Hadi, Sadeghi, Elahe, Abolnezhadian, Farhad, Goudarzi, Mehdi, Hemmati, Ali Asghar, Basir, Zahra, Kalantar, Mojtaba
Format:	Artikel
Sprache:	eng
Schlagworte:	Abietanes - pharmacology Abietanes - therapeutic use Animals Anti-inflammation Anti-inflammatory agents Anti-oxidant Antibiotics, Antineoplastic - toxicity Anticancer properties Antioxidants Antitumor agents Bleomycin Bleomycin - toxicity Carbonyl compounds Carbonyls Carnosol Catalase Dimethyl sulfoxide Dose-Response Relationship, Drug Fibrosis Glutathione Glutathione peroxidase Hydroxyproline Idiopathic pulmonary fibrosis Inflammation Interleukin 6 Lung - drug effects Lung - metabolism Lung cancer Lung diseases Lungs Male Malondialdehyde Nitric oxide Oral administration Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Peroxidase Pneumonia - chemically induced Pneumonia - drug therapy Pneumonia - metabolism Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - metabolism Rats Rats, Wistar Rosmarinus Superoxide dismutase
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