One-step Preparation of N-Unprotected Aziridines from 2H-Azirines by Addition of Ketene Silyl Acetals Catalyzed by Lewis Acids

The nucleophilic addition of ketene silyl acetals 2 into 2H-azirines 1 proceeded in the presence of Lewis acids such as InX3 or Sc(OTf)3 to give N-unprotected aziridines 3. The mild Lewis acidity of the catalyst is important for the achievement of this coupling. The generated aziridine 3 could then...

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Veröffentlicht in:	Chemistry letters 2022-01, Vol.51 (1), p.9-12
Hauptverfasser:	Suzuki, Itaru, Takenaka, Yuya, Morishita, Yoshitaka, Shibata, Ikuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetals Carbonyls
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description	The nucleophilic addition of ketene silyl acetals 2 into 2H-azirines 1 proceeded in the presence of Lewis acids such as InX3 or Sc(OTf)3 to give N-unprotected aziridines 3. The mild Lewis acidity of the catalyst is important for the achievement of this coupling. The generated aziridine 3 could then be transformed into either oxazolines or γ–amino carbonyls.
doi_str_mv	10.1246/cl.210589
format	Article
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source	Oxford University Press Journals All Titles (1996-Current)
subjects	Acetals Carbonyls
title	One-step Preparation of N-Unprotected Aziridines from 2H-Azirines by Addition of Ketene Silyl Acetals Catalyzed by Lewis Acids
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