Increasing Demeclocycline Production in Streptomyces aureofaciens by Manipulating the Expression of a Novel SARP Family Regulator and Its Genes

Demeclocycline (DMCTC), a tetracycline derivative antibiotic produced by Streptomyces aureofaciens , has attracted attention owing to its high bioavailability, prolonged maintenance of a therapeutic concentration, and greater efficacy against many infectious microorganisms. However, the productivity...

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Veröffentlicht in:	Biotechnology and bioprocess engineering 2021-12, Vol.26 (6), p.887-897
Hauptverfasser:	Tan, Yan-Ying, Zhu, Guang-Yao, Ye, Rui-Fang, Zhang, Hong-Zhou, Zhu, De-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Bioavailability Biosynthesis Biotechnology Chemistry Chemistry and Materials Science Demeclocycline Genes Industrial and Production Engineering Microorganisms Protein biosynthesis Proteins Research Paper Strains (organisms) Streptomyces
Online-Zugang:	Volltext
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