Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms

The insulin-like growth factor (IGF)2/IGF1 receptor (IGF1R) signaling axis has an important role in intestinal carcinogenesis and overexpression of IGF2 is an accepted risk factor for colorectal cancer (CRC) development. Genetic amplifications and loss of imprinting contribute to the upregulation of...

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Veröffentlicht in:	Oncogene 2017-09, Vol.36 (38), p.5341-5355
Hauptverfasser:	Unger, C, Kramer, N, Unterleuthner, D, Scherzer, M, Burian, A, Rudisch, A, Stadler, M, Schlederer, M, Lenhardt, D, Riedl, A, Walter, S, Wernitznig, A, Kenner, L, Hengstschläger, M, Schüler, J, Sommergruber, W, Dolznig, H
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/95 14/19 631/67/1504/1885 631/67/327 64/60 82 82/80 Actin AKT protein Animal models Animals Apoptosis Autocrine Communication Autocrine signalling Caco-2 Cells Carcinogenesis Care and treatment Cell Biology Cell Line, Tumor Cellular signal transduction Collagen Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Development and progression Disease Progression Extracellular matrix Female Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Gels Gene expression Genetic aspects Growth factors HCT116 Cells Health aspects Heterografts Human Genetics Humans Imprinting Insulin Insulin-like growth factor I Insulin-like growth factor II Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Internal Medicine Intestine Invasiveness Medicine Medicine & Public Health Mice Mice, Inbred NOD Muscle contraction Oncology original-article Paracrine Communication Paracrine signalling Receptors, Somatomedin - metabolism Risk factors Rodents Signal Transduction Smad protein Smooth muscle Stroma Stromal Cells - metabolism Stromal Cells - pathology Transfection Transforming growth factor-b Xenografts
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