Modified tunicamycins with reduced eukaryotic toxicity that enhance the antibacterial activity of β-lactams

Tunicamycins (TUN) are inhibitors of the UDP-HexNAc: polyprenol-P HexNAc-1-P transferase family of enzymes, which initiate the biosynthesis of bacterial peptidoglycan and catalyze the first step in eukaryotic protein N -glycosylation. The TUN are therefore general and potent toxins to both eukaryote...

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