Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children
Background Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune‐mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the...
Gespeichert in:
| Veröffentlicht in: | Pediatric allergy and immunology 2022-01, Vol.33 (1), p.e13613-n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 1 |
| container_start_page | e13613 |
| container_title | Pediatric allergy and immunology |
| container_volume | 33 |
| creator | Reinert‐Hartwall, Linnea Siljander, Heli Härkönen, Taina Vatanen, Tommi Ilonen, Jorma Niemelä, Onni Luopajärvi, Kristiina Dorshakova, Natalya Mokurov, Sergei Peet, Aleksandr Tillmann, Vallo Uibo, Raivo Knip, Mikael Vaarala, Outi Honkanen, Jarno Genuneit, Jon |
| description | Background
Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune‐mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the primary areas in contact with the environmental microbial load.
Methods
We analyzed the levels of 30 cytokines and growth factors in serum or plasma as markers of the immune maturation in the participants in the DIABIMMUNE study from Russian Karelia (n = 60), Estonia (n = 83) and Finland (n = 89), three neighboring countries with remarkable differences in the incidences of allergies, asthma and autoimmune diseases.
Results
We observed an upregulation of T helper cell signature cytokines during the first 12 months of life, reflecting natural development of adaptive immune responses. During the first years of life, circulating concentrations of epidermal growth factor (EGF) were significantly higher, especially in Russian children compared with Finnish children. The children who developed IgE sensitization showed lower levels of EGF than those without such responses.
Conclusion
Our results suggest that low circulating EGF levels associate with the risk of allergies possibly via the effects on the epithelial integrity and mucosal homeostasis. |
| doi_str_mv | 10.1111/pai.13613 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2615466910</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2615466910</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3883-de69f94e9b1549ba9ed83efb9a88f2ab18a1fde32080b4a4662b9b6e1b9710c83</originalsourceid><addsrcrecordid>eNp1kD1PwzAQQC0EoqUw8AeQJSaGUDtOE3usqn5JlWCA2bKdS-uSJsVOqMqvx5DCxi23vHsnPYRuKXmkYYZ7ZR8pSyk7Q33KhIgYYfwc9Ykgoyilo6yHrrzfEkKzQF2iHktYJjjN-ihf2PUGHDbWmbZUja3WeDqf4RI-oPRYeV8bqxrAB9tssMI5GAfKQ46d9W-4LvByPcUeKm8b-xnu6wrbCh_rNojMxpa5g-oaXRSq9HBz2gP0Opu-TBbR6mm-nIxXkWGcsyiHVBQiAaHpKBFaCcg5g0ILxXkRK025okUOLCac6EQlaRproVOgWmSUGM4G6L7z7l393oJv5LZuXRVeyjhkCAeCkkA9dJRxtfcOCrl3dqfcUVIiv3vK0FP-9Azs3cnY6h3kf-RvwAAMO-BgSzj-b5LP42Wn_AIh2n9r</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2615466910</pqid></control><display><type>article</type><title>Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Reinert‐Hartwall, Linnea ; Siljander, Heli ; Härkönen, Taina ; Vatanen, Tommi ; Ilonen, Jorma ; Niemelä, Onni ; Luopajärvi, Kristiina ; Dorshakova, Natalya ; Mokurov, Sergei ; Peet, Aleksandr ; Tillmann, Vallo ; Uibo, Raivo ; Knip, Mikael ; Vaarala, Outi ; Honkanen, Jarno ; Genuneit, Jon</creator><contributor>Genuneit, Jon</contributor><creatorcontrib>Reinert‐Hartwall, Linnea ; Siljander, Heli ; Härkönen, Taina ; Vatanen, Tommi ; Ilonen, Jorma ; Niemelä, Onni ; Luopajärvi, Kristiina ; Dorshakova, Natalya ; Mokurov, Sergei ; Peet, Aleksandr ; Tillmann, Vallo ; Uibo, Raivo ; Knip, Mikael ; Vaarala, Outi ; Honkanen, Jarno ; Genuneit, Jon ; DIABIMMUNE study group ; DIABIMMUNE study group ; Genuneit, Jon</creatorcontrib><description>Background
Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune‐mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the primary areas in contact with the environmental microbial load.
Methods
We analyzed the levels of 30 cytokines and growth factors in serum or plasma as markers of the immune maturation in the participants in the DIABIMMUNE study from Russian Karelia (n = 60), Estonia (n = 83) and Finland (n = 89), three neighboring countries with remarkable differences in the incidences of allergies, asthma and autoimmune diseases.
Results
We observed an upregulation of T helper cell signature cytokines during the first 12 months of life, reflecting natural development of adaptive immune responses. During the first years of life, circulating concentrations of epidermal growth factor (EGF) were significantly higher, especially in Russian children compared with Finnish children. The children who developed IgE sensitization showed lower levels of EGF than those without such responses.
Conclusion
Our results suggest that low circulating EGF levels associate with the risk of allergies possibly via the effects on the epithelial integrity and mucosal homeostasis.</description><identifier>ISSN: 0905-6157</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1111/pai.13613</identifier><identifier>PMID: 34379817</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adaptive immunity ; Allergens ; allergic sensitization ; Asthma ; Autoimmune diseases ; Child ; Child, Preschool ; Children ; cytokine ; Cytokines ; Epidermal Growth Factor ; epithelial integrity ; Helper cells ; Homeostasis ; Humans ; Hypersensitivity - epidemiology ; IgE ; Immune response ; Immunoglobulin E ; Lymphocytes T ; Microorganisms ; Mucosa ; Risk factors ; T helper cell</subject><ispartof>Pediatric allergy and immunology, 2022-01, Vol.33 (1), p.e13613-n/a</ispartof><rights>2021 The Authors. published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.</rights><rights>2021 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-de69f94e9b1549ba9ed83efb9a88f2ab18a1fde32080b4a4662b9b6e1b9710c83</citedby><cites>FETCH-LOGICAL-c3883-de69f94e9b1549ba9ed83efb9a88f2ab18a1fde32080b4a4662b9b6e1b9710c83</cites><orcidid>0000-0003-0474-0033 ; 0000-0002-0594-0822</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpai.13613$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpai.13613$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34379817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Genuneit, Jon</contributor><creatorcontrib>Reinert‐Hartwall, Linnea</creatorcontrib><creatorcontrib>Siljander, Heli</creatorcontrib><creatorcontrib>Härkönen, Taina</creatorcontrib><creatorcontrib>Vatanen, Tommi</creatorcontrib><creatorcontrib>Ilonen, Jorma</creatorcontrib><creatorcontrib>Niemelä, Onni</creatorcontrib><creatorcontrib>Luopajärvi, Kristiina</creatorcontrib><creatorcontrib>Dorshakova, Natalya</creatorcontrib><creatorcontrib>Mokurov, Sergei</creatorcontrib><creatorcontrib>Peet, Aleksandr</creatorcontrib><creatorcontrib>Tillmann, Vallo</creatorcontrib><creatorcontrib>Uibo, Raivo</creatorcontrib><creatorcontrib>Knip, Mikael</creatorcontrib><creatorcontrib>Vaarala, Outi</creatorcontrib><creatorcontrib>Honkanen, Jarno</creatorcontrib><creatorcontrib>Genuneit, Jon</creatorcontrib><creatorcontrib>DIABIMMUNE study group</creatorcontrib><creatorcontrib>DIABIMMUNE study group</creatorcontrib><title>Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>Background
Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune‐mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the primary areas in contact with the environmental microbial load.
Methods
We analyzed the levels of 30 cytokines and growth factors in serum or plasma as markers of the immune maturation in the participants in the DIABIMMUNE study from Russian Karelia (n = 60), Estonia (n = 83) and Finland (n = 89), three neighboring countries with remarkable differences in the incidences of allergies, asthma and autoimmune diseases.
Results
We observed an upregulation of T helper cell signature cytokines during the first 12 months of life, reflecting natural development of adaptive immune responses. During the first years of life, circulating concentrations of epidermal growth factor (EGF) were significantly higher, especially in Russian children compared with Finnish children. The children who developed IgE sensitization showed lower levels of EGF than those without such responses.
Conclusion
Our results suggest that low circulating EGF levels associate with the risk of allergies possibly via the effects on the epithelial integrity and mucosal homeostasis.</description><subject>Adaptive immunity</subject><subject>Allergens</subject><subject>allergic sensitization</subject><subject>Asthma</subject><subject>Autoimmune diseases</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>cytokine</subject><subject>Cytokines</subject><subject>Epidermal Growth Factor</subject><subject>epithelial integrity</subject><subject>Helper cells</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hypersensitivity - epidemiology</subject><subject>IgE</subject><subject>Immune response</subject><subject>Immunoglobulin E</subject><subject>Lymphocytes T</subject><subject>Microorganisms</subject><subject>Mucosa</subject><subject>Risk factors</subject><subject>T helper cell</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQQC0EoqUw8AeQJSaGUDtOE3usqn5JlWCA2bKdS-uSJsVOqMqvx5DCxi23vHsnPYRuKXmkYYZ7ZR8pSyk7Q33KhIgYYfwc9Ykgoyilo6yHrrzfEkKzQF2iHktYJjjN-ihf2PUGHDbWmbZUja3WeDqf4RI-oPRYeV8bqxrAB9tssMI5GAfKQ46d9W-4LvByPcUeKm8b-xnu6wrbCh_rNojMxpa5g-oaXRSq9HBz2gP0Opu-TBbR6mm-nIxXkWGcsyiHVBQiAaHpKBFaCcg5g0ILxXkRK025okUOLCac6EQlaRproVOgWmSUGM4G6L7z7l393oJv5LZuXRVeyjhkCAeCkkA9dJRxtfcOCrl3dqfcUVIiv3vK0FP-9Azs3cnY6h3kf-RvwAAMO-BgSzj-b5LP42Wn_AIh2n9r</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Reinert‐Hartwall, Linnea</creator><creator>Siljander, Heli</creator><creator>Härkönen, Taina</creator><creator>Vatanen, Tommi</creator><creator>Ilonen, Jorma</creator><creator>Niemelä, Onni</creator><creator>Luopajärvi, Kristiina</creator><creator>Dorshakova, Natalya</creator><creator>Mokurov, Sergei</creator><creator>Peet, Aleksandr</creator><creator>Tillmann, Vallo</creator><creator>Uibo, Raivo</creator><creator>Knip, Mikael</creator><creator>Vaarala, Outi</creator><creator>Honkanen, Jarno</creator><creator>Genuneit, Jon</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0003-0474-0033</orcidid><orcidid>https://orcid.org/0000-0002-0594-0822</orcidid></search><sort><creationdate>202201</creationdate><title>Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children</title><author>Reinert‐Hartwall, Linnea ; Siljander, Heli ; Härkönen, Taina ; Vatanen, Tommi ; Ilonen, Jorma ; Niemelä, Onni ; Luopajärvi, Kristiina ; Dorshakova, Natalya ; Mokurov, Sergei ; Peet, Aleksandr ; Tillmann, Vallo ; Uibo, Raivo ; Knip, Mikael ; Vaarala, Outi ; Honkanen, Jarno ; Genuneit, Jon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3883-de69f94e9b1549ba9ed83efb9a88f2ab18a1fde32080b4a4662b9b6e1b9710c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adaptive immunity</topic><topic>Allergens</topic><topic>allergic sensitization</topic><topic>Asthma</topic><topic>Autoimmune diseases</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>cytokine</topic><topic>Cytokines</topic><topic>Epidermal Growth Factor</topic><topic>epithelial integrity</topic><topic>Helper cells</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hypersensitivity - epidemiology</topic><topic>IgE</topic><topic>Immune response</topic><topic>Immunoglobulin E</topic><topic>Lymphocytes T</topic><topic>Microorganisms</topic><topic>Mucosa</topic><topic>Risk factors</topic><topic>T helper cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reinert‐Hartwall, Linnea</creatorcontrib><creatorcontrib>Siljander, Heli</creatorcontrib><creatorcontrib>Härkönen, Taina</creatorcontrib><creatorcontrib>Vatanen, Tommi</creatorcontrib><creatorcontrib>Ilonen, Jorma</creatorcontrib><creatorcontrib>Niemelä, Onni</creatorcontrib><creatorcontrib>Luopajärvi, Kristiina</creatorcontrib><creatorcontrib>Dorshakova, Natalya</creatorcontrib><creatorcontrib>Mokurov, Sergei</creatorcontrib><creatorcontrib>Peet, Aleksandr</creatorcontrib><creatorcontrib>Tillmann, Vallo</creatorcontrib><creatorcontrib>Uibo, Raivo</creatorcontrib><creatorcontrib>Knip, Mikael</creatorcontrib><creatorcontrib>Vaarala, Outi</creatorcontrib><creatorcontrib>Honkanen, Jarno</creatorcontrib><creatorcontrib>Genuneit, Jon</creatorcontrib><creatorcontrib>DIABIMMUNE study group</creatorcontrib><creatorcontrib>DIABIMMUNE study group</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reinert‐Hartwall, Linnea</au><au>Siljander, Heli</au><au>Härkönen, Taina</au><au>Vatanen, Tommi</au><au>Ilonen, Jorma</au><au>Niemelä, Onni</au><au>Luopajärvi, Kristiina</au><au>Dorshakova, Natalya</au><au>Mokurov, Sergei</au><au>Peet, Aleksandr</au><au>Tillmann, Vallo</au><au>Uibo, Raivo</au><au>Knip, Mikael</au><au>Vaarala, Outi</au><au>Honkanen, Jarno</au><au>Genuneit, Jon</au><au>Genuneit, Jon</au><aucorp>DIABIMMUNE study group</aucorp><aucorp>DIABIMMUNE study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2022-01</date><risdate>2022</risdate><volume>33</volume><issue>1</issue><spage>e13613</spage><epage>n/a</epage><pages>e13613-n/a</pages><issn>0905-6157</issn><eissn>1399-3038</eissn><abstract>Background
Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune‐mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the primary areas in contact with the environmental microbial load.
Methods
We analyzed the levels of 30 cytokines and growth factors in serum or plasma as markers of the immune maturation in the participants in the DIABIMMUNE study from Russian Karelia (n = 60), Estonia (n = 83) and Finland (n = 89), three neighboring countries with remarkable differences in the incidences of allergies, asthma and autoimmune diseases.
Results
We observed an upregulation of T helper cell signature cytokines during the first 12 months of life, reflecting natural development of adaptive immune responses. During the first years of life, circulating concentrations of epidermal growth factor (EGF) were significantly higher, especially in Russian children compared with Finnish children. The children who developed IgE sensitization showed lower levels of EGF than those without such responses.
Conclusion
Our results suggest that low circulating EGF levels associate with the risk of allergies possibly via the effects on the epithelial integrity and mucosal homeostasis.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34379817</pmid><doi>10.1111/pai.13613</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0474-0033</orcidid><orcidid>https://orcid.org/0000-0002-0594-0822</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0905-6157 |
| ispartof | Pediatric allergy and immunology, 2022-01, Vol.33 (1), p.e13613-n/a |
| issn | 0905-6157 1399-3038 |
| language | eng |
| recordid | cdi_proquest_journals_2615466910 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adaptive immunity Allergens allergic sensitization Asthma Autoimmune diseases Child Child, Preschool Children cytokine Cytokines Epidermal Growth Factor epithelial integrity Helper cells Homeostasis Humans Hypersensitivity - epidemiology IgE Immune response Immunoglobulin E Lymphocytes T Microorganisms Mucosa Risk factors T helper cell |
| title | Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T20%3A53%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Higher%20circulating%20EGF%20levels%20associate%20with%20a%20decreased%20risk%20of%20IgE%20sensitization%20in%20young%20children&rft.jtitle=Pediatric%20allergy%20and%20immunology&rft.au=Reinert%E2%80%90Hartwall,%20Linnea&rft.aucorp=DIABIMMUNE%20study%20group&rft.date=2022-01&rft.volume=33&rft.issue=1&rft.spage=e13613&rft.epage=n/a&rft.pages=e13613-n/a&rft.issn=0905-6157&rft.eissn=1399-3038&rft_id=info:doi/10.1111/pai.13613&rft_dat=%3Cproquest_cross%3E2615466910%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2615466910&rft_id=info:pmid/34379817&rfr_iscdi=true |