Higher dietary insulinaemic potential is associated with increased risk of liver steatosis and fibrosis
Background and Aims Hyperinsulinaemia and insulin resistance play a central role in the progression of hepatic steatosis and fibrosis, and diet can modulate insulin response. We thus hypothesised that diet with higher insulinaemic potential is associated with an increased risk of these conditions. M...
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| Veröffentlicht in: | Liver international 2022-01, Vol.42 (1), p.69-79 |
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| creator | Zhu, Yu Peng, Zhaohong Lu, Yao Li, Hairong Zeng, Xufen Zhang, Zhuang Li, Xiude Hu, Chunqiu Hu, Anla Zhao, Qihong Wang, Hua Yang, Wanshui |
| description | Background and Aims
Hyperinsulinaemia and insulin resistance play a central role in the progression of hepatic steatosis and fibrosis, and diet can modulate insulin response. We thus hypothesised that diet with higher insulinaemic potential is associated with an increased risk of these conditions.
Methods
Two empirically dietary indices for hyperinsulinaemia (EDIH) and insulin resistance (EDIR) were derived to identify food groups most predictive of fasting concentrations of C‐peptide and insulin and homeostatic model assessment for insulin resistance respectively. Hepatic steatosis and fibrosis were defined by controlled attenuation parameter and liver stiffness measurement using transient elastography (TE). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression.
Results
Of the 4171 participants with TE examination, 1436 (age‐standardised prevalence, 33.8%) were diagnosed with steatosis, 255 (5.6%) with advanced fibrosis and 101 (2.2%) with cirrhosis. The multivariable‐adjusted ORs for participants comparing the highest to the lowest EDIH tertile were 1.17 (95% CI: 0.99‐1.39, Ptrend = .005) for steatosis, 1.74 (95% CI: 1.24‐2.44, Ptrend = .001) for advanced fibrosis and 2.05 (95% CI: 1.21‐3.46, Ptrend = .004) for cirrhosis. Similar associations were observed for EDIR with ORs of 1.32 (95% CI: 1.11‐1.55, Ptrend |
| doi_str_mv | 10.1111/liv.15057 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2615065741</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2615065741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3537-db2c515f0259fe75d1a70e59b1da9daf4c2c33cf32dcfe2cd3fdf047fd88ec413</originalsourceid><addsrcrecordid>eNp1kE1PAjEQhhujEUQP_gHTxJOHhX5sWfZojAoJiRf1uum2Uyguu9h2Jfx7C4vc7KWd5OkzMy9Ct5QMaTyjyv4MqSAiO0N9mmaThDNOz09vxnvoyvsVITTPBb1EPZ4KRqlgfbSY2sUSHNYWgnQ7bGvfVraWsLYKb5oAdbCywtZj6X2jrAyg8daGZSSVA-lj6az_wo3BcYxo8gFkaPz-R62xsaXbF9fowsjKw83xHqCPl-f3p2kyf3udPT3OE8UFzxJdMiWoMISJ3EAmNJUZAZGXVMtcS5MqpjhXhjOtDDCludGGpJnRkwmolPIBuu-8G9d8t-BDsWpaV8eWBRvHjMYiO1APHaXicN6BKTbOruP-BSXFPtIi7lIcIo3s3dHYlmvQJ_IvwwiMOmBrK9j9byrms89O-QsUDoLC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2615065741</pqid></control><display><type>article</type><title>Higher dietary insulinaemic potential is associated with increased risk of liver steatosis and fibrosis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zhu, Yu ; Peng, Zhaohong ; Lu, Yao ; Li, Hairong ; Zeng, Xufen ; Zhang, Zhuang ; Li, Xiude ; Hu, Chunqiu ; Hu, Anla ; Zhao, Qihong ; Wang, Hua ; Yang, Wanshui</creator><creatorcontrib>Zhu, Yu ; Peng, Zhaohong ; Lu, Yao ; Li, Hairong ; Zeng, Xufen ; Zhang, Zhuang ; Li, Xiude ; Hu, Chunqiu ; Hu, Anla ; Zhao, Qihong ; Wang, Hua ; Yang, Wanshui</creatorcontrib><description>Background and Aims
Hyperinsulinaemia and insulin resistance play a central role in the progression of hepatic steatosis and fibrosis, and diet can modulate insulin response. We thus hypothesised that diet with higher insulinaemic potential is associated with an increased risk of these conditions.
Methods
Two empirically dietary indices for hyperinsulinaemia (EDIH) and insulin resistance (EDIR) were derived to identify food groups most predictive of fasting concentrations of C‐peptide and insulin and homeostatic model assessment for insulin resistance respectively. Hepatic steatosis and fibrosis were defined by controlled attenuation parameter and liver stiffness measurement using transient elastography (TE). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression.
Results
Of the 4171 participants with TE examination, 1436 (age‐standardised prevalence, 33.8%) were diagnosed with steatosis, 255 (5.6%) with advanced fibrosis and 101 (2.2%) with cirrhosis. The multivariable‐adjusted ORs for participants comparing the highest to the lowest EDIH tertile were 1.17 (95% CI: 0.99‐1.39, Ptrend = .005) for steatosis, 1.74 (95% CI: 1.24‐2.44, Ptrend = .001) for advanced fibrosis and 2.05 (95% CI: 1.21‐3.46, Ptrend = .004) for cirrhosis. Similar associations were observed for EDIR with ORs of 1.32 (95% CI: 1.11‐1.55, Ptrend < .001) for steatosis and 1.43 (95% CI: 1.03‐1.99, Ptrend = .006) for advance fibrosis. These positive associations remained among never drinkers and individuals who were free of hepatitis B and/or C.
Conclusions
Our findings suggest that hyperinsulinaemia and insulin resistance may partially underlie the influence of diet on hepatic steatosis and fibrosis, and highlight the importance of reducing or avoiding insulinaemic dietary pattern.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.15057</identifier><identifier>PMID: 34521152</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Attenuation ; Cirrhosis ; Confidence intervals ; controlled attenuation parameter ; Diet ; dietary pattern ; Elasticity Imaging Techniques ; Fatty liver ; Fibrosis ; Food groups ; Hepatitis B ; Humans ; hyperinsulinaemia ; Insulin ; Insulin resistance ; Liver ; Liver - pathology ; Liver cirrhosis ; Liver Cirrhosis - complications ; liver stiffness measurement ; Non-alcoholic Fatty Liver Disease - complications ; Statistical analysis ; Steatosis ; Stiffness</subject><ispartof>Liver international, 2022-01, Vol.42 (1), p.69-79</ispartof><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-db2c515f0259fe75d1a70e59b1da9daf4c2c33cf32dcfe2cd3fdf047fd88ec413</citedby><cites>FETCH-LOGICAL-c3537-db2c515f0259fe75d1a70e59b1da9daf4c2c33cf32dcfe2cd3fdf047fd88ec413</cites><orcidid>0000-0002-7365-2689 ; 0000-0002-2605-5697</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fliv.15057$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fliv.15057$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34521152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Yu</creatorcontrib><creatorcontrib>Peng, Zhaohong</creatorcontrib><creatorcontrib>Lu, Yao</creatorcontrib><creatorcontrib>Li, Hairong</creatorcontrib><creatorcontrib>Zeng, Xufen</creatorcontrib><creatorcontrib>Zhang, Zhuang</creatorcontrib><creatorcontrib>Li, Xiude</creatorcontrib><creatorcontrib>Hu, Chunqiu</creatorcontrib><creatorcontrib>Hu, Anla</creatorcontrib><creatorcontrib>Zhao, Qihong</creatorcontrib><creatorcontrib>Wang, Hua</creatorcontrib><creatorcontrib>Yang, Wanshui</creatorcontrib><title>Higher dietary insulinaemic potential is associated with increased risk of liver steatosis and fibrosis</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background and Aims
Hyperinsulinaemia and insulin resistance play a central role in the progression of hepatic steatosis and fibrosis, and diet can modulate insulin response. We thus hypothesised that diet with higher insulinaemic potential is associated with an increased risk of these conditions.
Methods
Two empirically dietary indices for hyperinsulinaemia (EDIH) and insulin resistance (EDIR) were derived to identify food groups most predictive of fasting concentrations of C‐peptide and insulin and homeostatic model assessment for insulin resistance respectively. Hepatic steatosis and fibrosis were defined by controlled attenuation parameter and liver stiffness measurement using transient elastography (TE). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression.
Results
Of the 4171 participants with TE examination, 1436 (age‐standardised prevalence, 33.8%) were diagnosed with steatosis, 255 (5.6%) with advanced fibrosis and 101 (2.2%) with cirrhosis. The multivariable‐adjusted ORs for participants comparing the highest to the lowest EDIH tertile were 1.17 (95% CI: 0.99‐1.39, Ptrend = .005) for steatosis, 1.74 (95% CI: 1.24‐2.44, Ptrend = .001) for advanced fibrosis and 2.05 (95% CI: 1.21‐3.46, Ptrend = .004) for cirrhosis. Similar associations were observed for EDIR with ORs of 1.32 (95% CI: 1.11‐1.55, Ptrend < .001) for steatosis and 1.43 (95% CI: 1.03‐1.99, Ptrend = .006) for advance fibrosis. These positive associations remained among never drinkers and individuals who were free of hepatitis B and/or C.
Conclusions
Our findings suggest that hyperinsulinaemia and insulin resistance may partially underlie the influence of diet on hepatic steatosis and fibrosis, and highlight the importance of reducing or avoiding insulinaemic dietary pattern.</description><subject>Attenuation</subject><subject>Cirrhosis</subject><subject>Confidence intervals</subject><subject>controlled attenuation parameter</subject><subject>Diet</subject><subject>dietary pattern</subject><subject>Elasticity Imaging Techniques</subject><subject>Fatty liver</subject><subject>Fibrosis</subject><subject>Food groups</subject><subject>Hepatitis B</subject><subject>Humans</subject><subject>hyperinsulinaemia</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Liver</subject><subject>Liver - pathology</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - complications</subject><subject>liver stiffness measurement</subject><subject>Non-alcoholic Fatty Liver Disease - complications</subject><subject>Statistical analysis</subject><subject>Steatosis</subject><subject>Stiffness</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PAjEQhhujEUQP_gHTxJOHhX5sWfZojAoJiRf1uum2Uyguu9h2Jfx7C4vc7KWd5OkzMy9Ct5QMaTyjyv4MqSAiO0N9mmaThDNOz09vxnvoyvsVITTPBb1EPZ4KRqlgfbSY2sUSHNYWgnQ7bGvfVraWsLYKb5oAdbCywtZj6X2jrAyg8daGZSSVA-lj6az_wo3BcYxo8gFkaPz-R62xsaXbF9fowsjKw83xHqCPl-f3p2kyf3udPT3OE8UFzxJdMiWoMISJ3EAmNJUZAZGXVMtcS5MqpjhXhjOtDDCludGGpJnRkwmolPIBuu-8G9d8t-BDsWpaV8eWBRvHjMYiO1APHaXicN6BKTbOruP-BSXFPtIi7lIcIo3s3dHYlmvQJ_IvwwiMOmBrK9j9byrms89O-QsUDoLC</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Zhu, Yu</creator><creator>Peng, Zhaohong</creator><creator>Lu, Yao</creator><creator>Li, Hairong</creator><creator>Zeng, Xufen</creator><creator>Zhang, Zhuang</creator><creator>Li, Xiude</creator><creator>Hu, Chunqiu</creator><creator>Hu, Anla</creator><creator>Zhao, Qihong</creator><creator>Wang, Hua</creator><creator>Yang, Wanshui</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-7365-2689</orcidid><orcidid>https://orcid.org/0000-0002-2605-5697</orcidid></search><sort><creationdate>202201</creationdate><title>Higher dietary insulinaemic potential is associated with increased risk of liver steatosis and fibrosis</title><author>Zhu, Yu ; Peng, Zhaohong ; Lu, Yao ; Li, Hairong ; Zeng, Xufen ; Zhang, Zhuang ; Li, Xiude ; Hu, Chunqiu ; Hu, Anla ; Zhao, Qihong ; Wang, Hua ; Yang, Wanshui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-db2c515f0259fe75d1a70e59b1da9daf4c2c33cf32dcfe2cd3fdf047fd88ec413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Attenuation</topic><topic>Cirrhosis</topic><topic>Confidence intervals</topic><topic>controlled attenuation parameter</topic><topic>Diet</topic><topic>dietary pattern</topic><topic>Elasticity Imaging Techniques</topic><topic>Fatty liver</topic><topic>Fibrosis</topic><topic>Food groups</topic><topic>Hepatitis B</topic><topic>Humans</topic><topic>hyperinsulinaemia</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Liver</topic><topic>Liver - pathology</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - complications</topic><topic>liver stiffness measurement</topic><topic>Non-alcoholic Fatty Liver Disease - complications</topic><topic>Statistical analysis</topic><topic>Steatosis</topic><topic>Stiffness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Yu</creatorcontrib><creatorcontrib>Peng, Zhaohong</creatorcontrib><creatorcontrib>Lu, Yao</creatorcontrib><creatorcontrib>Li, Hairong</creatorcontrib><creatorcontrib>Zeng, Xufen</creatorcontrib><creatorcontrib>Zhang, Zhuang</creatorcontrib><creatorcontrib>Li, Xiude</creatorcontrib><creatorcontrib>Hu, Chunqiu</creatorcontrib><creatorcontrib>Hu, Anla</creatorcontrib><creatorcontrib>Zhao, Qihong</creatorcontrib><creatorcontrib>Wang, Hua</creatorcontrib><creatorcontrib>Yang, Wanshui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Yu</au><au>Peng, Zhaohong</au><au>Lu, Yao</au><au>Li, Hairong</au><au>Zeng, Xufen</au><au>Zhang, Zhuang</au><au>Li, Xiude</au><au>Hu, Chunqiu</au><au>Hu, Anla</au><au>Zhao, Qihong</au><au>Wang, Hua</au><au>Yang, Wanshui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher dietary insulinaemic potential is associated with increased risk of liver steatosis and fibrosis</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2022-01</date><risdate>2022</risdate><volume>42</volume><issue>1</issue><spage>69</spage><epage>79</epage><pages>69-79</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background and Aims
Hyperinsulinaemia and insulin resistance play a central role in the progression of hepatic steatosis and fibrosis, and diet can modulate insulin response. We thus hypothesised that diet with higher insulinaemic potential is associated with an increased risk of these conditions.
Methods
Two empirically dietary indices for hyperinsulinaemia (EDIH) and insulin resistance (EDIR) were derived to identify food groups most predictive of fasting concentrations of C‐peptide and insulin and homeostatic model assessment for insulin resistance respectively. Hepatic steatosis and fibrosis were defined by controlled attenuation parameter and liver stiffness measurement using transient elastography (TE). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression.
Results
Of the 4171 participants with TE examination, 1436 (age‐standardised prevalence, 33.8%) were diagnosed with steatosis, 255 (5.6%) with advanced fibrosis and 101 (2.2%) with cirrhosis. The multivariable‐adjusted ORs for participants comparing the highest to the lowest EDIH tertile were 1.17 (95% CI: 0.99‐1.39, Ptrend = .005) for steatosis, 1.74 (95% CI: 1.24‐2.44, Ptrend = .001) for advanced fibrosis and 2.05 (95% CI: 1.21‐3.46, Ptrend = .004) for cirrhosis. Similar associations were observed for EDIR with ORs of 1.32 (95% CI: 1.11‐1.55, Ptrend < .001) for steatosis and 1.43 (95% CI: 1.03‐1.99, Ptrend = .006) for advance fibrosis. These positive associations remained among never drinkers and individuals who were free of hepatitis B and/or C.
Conclusions
Our findings suggest that hyperinsulinaemia and insulin resistance may partially underlie the influence of diet on hepatic steatosis and fibrosis, and highlight the importance of reducing or avoiding insulinaemic dietary pattern.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34521152</pmid><doi>10.1111/liv.15057</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-7365-2689</orcidid><orcidid>https://orcid.org/0000-0002-2605-5697</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Attenuation Cirrhosis Confidence intervals controlled attenuation parameter Diet dietary pattern Elasticity Imaging Techniques Fatty liver Fibrosis Food groups Hepatitis B Humans hyperinsulinaemia Insulin Insulin resistance Liver Liver - pathology Liver cirrhosis Liver Cirrhosis - complications liver stiffness measurement Non-alcoholic Fatty Liver Disease - complications Statistical analysis Steatosis Stiffness |
| title | Higher dietary insulinaemic potential is associated with increased risk of liver steatosis and fibrosis |
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