In Silico Analysis and Experimental Evaluation of Ester Prodrugs of Ketoprofen for Oral Delivery: With a View to Reduce Toxicity

The present research aimed to synthesize ketoprofen prodrugs and to demonstrate their potentiality for oral treatment to treat chronic inflammation by reducing its hepatotoxicity and gastrointestinal irritation. Methyl 2-(3-benzoyl phenyl) propanoate, ethyl 2-(3-benzoyl phenyl) propanoate and propyl...

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Veröffentlicht in:	Processes 2021-12, Vol.9 (12), p.2221
Hauptverfasser:	Mazumder, Kishor, Hossain, Md. Emran, Aktar, Asma, Mohiuddin, Mohammad, Sarkar, Kishore Kumar, Biswas, Biswajit, Aziz, Md. Abdullah, Abid, Md. Ahsan, Fukase, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Bioavailability Biocompatibility Chromatography Drug dosages Drugs Enzymes Esterification Experiments FDA approval Hepatotoxicity In vivo methods and tests Inflammatory diseases Infrared analysis Irritation Ketoprofen Laboratories Metabolism NMR Nuclear magnetic resonance Osteoarthritis Pain Pathogenesis Permeability Pharmacokinetics Prodrugs Proteolysis Rheumatoid arthritis Spectrometry Statistical analysis Synthesis Toxicity
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