Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases
Aryl Hydrocarbon Receptor (AhR) is an evolutionary transcription factor which acts as a crucial sensor of different exogenous and endogenous molecules Recent data indicate that AhR is implicated in several physiological processes such as cell physiology, host defense, proliferation and differentiati...
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| Veröffentlicht in: | Cells (Basel, Switzerland) Switzerland), 2021-12, Vol.10 (12), p.3559, Article 3559 |
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| creator | Napolitano, Maddalena Fabbrocini, Gabriella Martora, Fabrizio Picone, Vincenzo Morelli, Paola Patruno, Cataldo |
| description | Aryl Hydrocarbon Receptor (AhR) is an evolutionary transcription factor which acts as a crucial sensor of different exogenous and endogenous molecules Recent data indicate that AhR is implicated in several physiological processes such as cell physiology, host defense, proliferation and differentiation of immune cells, and detoxification. Moreover, AhR involvement has been reported in the development and maintenance of several pathological conditions. In recent years, an increasing number of studies have accumulated highlighting the regulatory role of AhR in the physiology of the skin. However, there is evidence of both beneficial and harmful effects of AHR signaling. At present, most of the evidence concerns inflammatory skin diseases, in particular atopic dermatitis, psoriasis, acne, and hidradenitis suppurativa. This review exam-ines the role of AhR in skin homeostasis and the therapeutic implication of its pharmacological modulation in these cutaneous inflammatory diseases. |
| doi_str_mv | 10.3390/cells10123559 |
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Moreover, AhR involvement has been reported in the development and maintenance of several pathological conditions. In recent years, an increasing number of studies have accumulated highlighting the regulatory role of AhR in the physiology of the skin. However, there is evidence of both beneficial and harmful effects of AHR signaling. At present, most of the evidence concerns inflammatory skin diseases, in particular atopic dermatitis, psoriasis, acne, and hidradenitis suppurativa. This review exam-ines the role of AhR in skin homeostasis and the therapeutic implication of its pharmacological modulation in these cutaneous inflammatory diseases.</description><identifier>ISSN: 2073-4409</identifier><identifier>EISSN: 2073-4409</identifier><identifier>DOI: 10.3390/cells10123559</identifier><identifier>PMID: 34944067</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Acne ; aryl hydrocarbon receptor ; Atopic dermatitis ; Basic Helix-Loop-Helix Transcription Factors - genetics ; Cell Biology ; Cell cycle ; Cell differentiation ; Cell Differentiation - genetics ; Cell proliferation ; Chronic Disease - epidemiology ; Dendritic cells ; Dermatitis, Atopic ; Detoxification ; Enzymes ; Flavonoids ; Gene Expression Regulation - genetics ; hidradenitis suppurativa ; Homeostasis ; Humans ; Hydrocarbons ; Inflammation - epidemiology ; Inflammation - genetics ; Inflammation - pathology ; Inflammatory diseases ; Keratinocytes - metabolism ; Keratinocytes - pathology ; Kinases ; Life Sciences & Biomedicine ; Ligands ; Metabolism ; Metabolites ; Oxidative Stress - genetics ; Phosphorylation ; Physiology ; Proteins ; Psoriasis ; Psoriasis - epidemiology ; Psoriasis - genetics ; Psoriasis - pathology ; Receptor mechanisms ; Receptors, Aryl Hydrocarbon - genetics ; Review ; Science & Technology ; Skin - metabolism ; Skin - pathology ; Skin cancer ; Skin diseases ; Skin Diseases - epidemiology ; Skin Diseases - genetics ; Skin Diseases - pathology ; Transcription factors</subject><ispartof>Cells (Basel, Switzerland), 2021-12, Vol.10 (12), p.3559, Article 3559</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>40</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000735884000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c481t-d89bfb66e1a23662c9476ec3a5c8b9492fb61c9ee138cf6c0c99bc38123ba2433</citedby><cites>FETCH-LOGICAL-c481t-d89bfb66e1a23662c9476ec3a5c8b9492fb61c9ee138cf6c0c99bc38123ba2433</cites><orcidid>0000-0002-8137-8392 ; 0000-0003-3309-8190 ; 0000-0003-2523-050X ; 0000-0001-8661-2822</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700074/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700074/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34944067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Napolitano, Maddalena</creatorcontrib><creatorcontrib>Fabbrocini, Gabriella</creatorcontrib><creatorcontrib>Martora, Fabrizio</creatorcontrib><creatorcontrib>Picone, Vincenzo</creatorcontrib><creatorcontrib>Morelli, Paola</creatorcontrib><creatorcontrib>Patruno, Cataldo</creatorcontrib><title>Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases</title><title>Cells (Basel, Switzerland)</title><addtitle>CELLS-BASEL</addtitle><addtitle>Cells</addtitle><description>Aryl Hydrocarbon Receptor (AhR) is an evolutionary transcription factor which acts as a crucial sensor of different exogenous and endogenous molecules Recent data indicate that AhR is implicated in several physiological processes such as cell physiology, host defense, proliferation and differentiation of immune cells, and detoxification. Moreover, AhR involvement has been reported in the development and maintenance of several pathological conditions. In recent years, an increasing number of studies have accumulated highlighting the regulatory role of AhR in the physiology of the skin. However, there is evidence of both beneficial and harmful effects of AHR signaling. At present, most of the evidence concerns inflammatory skin diseases, in particular atopic dermatitis, psoriasis, acne, and hidradenitis suppurativa. This review exam-ines the role of AhR in skin homeostasis and the therapeutic implication of its pharmacological modulation in these cutaneous inflammatory diseases.</description><subject>Acne</subject><subject>aryl hydrocarbon receptor</subject><subject>Atopic dermatitis</subject><subject>Basic Helix-Loop-Helix Transcription Factors - genetics</subject><subject>Cell Biology</subject><subject>Cell cycle</subject><subject>Cell differentiation</subject><subject>Cell Differentiation - genetics</subject><subject>Cell proliferation</subject><subject>Chronic Disease - epidemiology</subject><subject>Dendritic cells</subject><subject>Dermatitis, Atopic</subject><subject>Detoxification</subject><subject>Enzymes</subject><subject>Flavonoids</subject><subject>Gene Expression Regulation - genetics</subject><subject>hidradenitis suppurativa</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hydrocarbons</subject><subject>Inflammation - epidemiology</subject><subject>Inflammation - 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genetics</topic><topic>Cell Biology</topic><topic>Cell cycle</topic><topic>Cell differentiation</topic><topic>Cell Differentiation - genetics</topic><topic>Cell proliferation</topic><topic>Chronic Disease - epidemiology</topic><topic>Dendritic cells</topic><topic>Dermatitis, Atopic</topic><topic>Detoxification</topic><topic>Enzymes</topic><topic>Flavonoids</topic><topic>Gene Expression Regulation - genetics</topic><topic>hidradenitis suppurativa</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hydrocarbons</topic><topic>Inflammation - epidemiology</topic><topic>Inflammation - genetics</topic><topic>Inflammation - pathology</topic><topic>Inflammatory diseases</topic><topic>Keratinocytes - metabolism</topic><topic>Keratinocytes - pathology</topic><topic>Kinases</topic><topic>Life Sciences & Biomedicine</topic><topic>Ligands</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Oxidative Stress - genetics</topic><topic>Phosphorylation</topic><topic>Physiology</topic><topic>Proteins</topic><topic>Psoriasis</topic><topic>Psoriasis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cells (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Napolitano, Maddalena</au><au>Fabbrocini, Gabriella</au><au>Martora, Fabrizio</au><au>Picone, Vincenzo</au><au>Morelli, Paola</au><au>Patruno, Cataldo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases</atitle><jtitle>Cells (Basel, Switzerland)</jtitle><stitle>CELLS-BASEL</stitle><addtitle>Cells</addtitle><date>2021-12-16</date><risdate>2021</risdate><volume>10</volume><issue>12</issue><spage>3559</spage><pages>3559-</pages><artnum>3559</artnum><issn>2073-4409</issn><eissn>2073-4409</eissn><abstract>Aryl Hydrocarbon Receptor (AhR) is an evolutionary transcription factor which acts as a crucial sensor of different exogenous and endogenous molecules Recent data indicate that AhR is implicated in several physiological processes such as cell physiology, host defense, proliferation and differentiation of immune cells, and detoxification. Moreover, AhR involvement has been reported in the development and maintenance of several pathological conditions. In recent years, an increasing number of studies have accumulated highlighting the regulatory role of AhR in the physiology of the skin. However, there is evidence of both beneficial and harmful effects of AHR signaling. At present, most of the evidence concerns inflammatory skin diseases, in particular atopic dermatitis, psoriasis, acne, and hidradenitis suppurativa. 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| subjects | Acne aryl hydrocarbon receptor Atopic dermatitis Basic Helix-Loop-Helix Transcription Factors - genetics Cell Biology Cell cycle Cell differentiation Cell Differentiation - genetics Cell proliferation Chronic Disease - epidemiology Dendritic cells Dermatitis, Atopic Detoxification Enzymes Flavonoids Gene Expression Regulation - genetics hidradenitis suppurativa Homeostasis Humans Hydrocarbons Inflammation - epidemiology Inflammation - genetics Inflammation - pathology Inflammatory diseases Keratinocytes - metabolism Keratinocytes - pathology Kinases Life Sciences & Biomedicine Ligands Metabolism Metabolites Oxidative Stress - genetics Phosphorylation Physiology Proteins Psoriasis Psoriasis - epidemiology Psoriasis - genetics Psoriasis - pathology Receptor mechanisms Receptors, Aryl Hydrocarbon - genetics Review Science & Technology Skin - metabolism Skin - pathology Skin cancer Skin diseases Skin Diseases - epidemiology Skin Diseases - genetics Skin Diseases - pathology Transcription factors |
| title | Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases |
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