Association between Cardiac Auscultation and Echocardiographic Findings in Warmblood Horses

Simple Summary In our study, we retrospectively analyzed cardiac examinations in a large number of warmblood horses conducted over a period of almost 20 years. We compared the results of the cardiac auscultation as the character and grade of a heart murmur with the results of the echocardiographic e...

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Veröffentlicht in:Animals (Basel) 2021-12, Vol.11 (12), p.3463, Article 3463
Hauptverfasser: Hoevener, Jakob, Pokar, Julie, Merle, Roswitha, Gehlen, Heidrun
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Pokar, Julie
Merle, Roswitha
Gehlen, Heidrun
description Simple Summary In our study, we retrospectively analyzed cardiac examinations in a large number of warmblood horses conducted over a period of almost 20 years. We compared the results of the cardiac auscultation as the character and grade of a heart murmur with the results of the echocardiographic examination. We found that auscultation works very well to identify the valve affected, if following the general clinical guidelines on which kind of murmur is usually caused by specific valvular regurgitations. Auscultation is less specific in determining the grade of the regurgitation based on the loudness of the murmur. Only low-grade murmurs are usually caused by mild regurgitations, while differentiation between moderate and severe regurgitations based on the loudness of the murmur is not reliable. Moreover, we could not find that enlargement of one or more compartments of the heart generally leads to a higher-grade murmur. Heart murmurs are detected frequently when auscultating horses and certain murmurs can usually be linked to specific valvular regurgitations. Limited information exists about the accuracy of these broad rules in warmblood horses and the influence of grade of the regurgitation and dimensional changes on murmur intensity. This study aims to clarify the accuracy of cardiac auscultation in warmblood horses and the influence of the grade of regurgitation and dimensional changes on the loudness of the murmur. In this retrospective study, 822 warmblood horses presented for cardiac examination in a large equine referral center in northern Germany underwent a thorough cardiac auscultation. In total, 653 of these revealed one or more heart murmurs. Most common auscultatory findings were left-sided systolic murmurs (68%) or left-sided diastolic murmurs (15%). On 635 of these horses, an echocardiographic examination was performed, revealing regurgitations of the mitral valve as the most common valvular regurgitation (77%) followed by regurgitations of the aortic valve (23%). Thirty-one percent of horses that underwent echocardiographic examination displayed dimensional changes of one or more compartments of the heart, with the left atrium being most affected (21%), followed by the left ventricle (13%). The main goal of this study was to link certain auscultatory findings with results of the echocardiographic examinations, trying to determine whether auscultation and echocardiography agreed on the valve affected, as well as to find out if loudness of
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We compared the results of the cardiac auscultation as the character and grade of a heart murmur with the results of the echocardiographic examination. We found that auscultation works very well to identify the valve affected, if following the general clinical guidelines on which kind of murmur is usually caused by specific valvular regurgitations. Auscultation is less specific in determining the grade of the regurgitation based on the loudness of the murmur. Only low-grade murmurs are usually caused by mild regurgitations, while differentiation between moderate and severe regurgitations based on the loudness of the murmur is not reliable. Moreover, we could not find that enlargement of one or more compartments of the heart generally leads to a higher-grade murmur. Heart murmurs are detected frequently when auscultating horses and certain murmurs can usually be linked to specific valvular regurgitations. Limited information exists about the accuracy of these broad rules in warmblood horses and the influence of grade of the regurgitation and dimensional changes on murmur intensity. This study aims to clarify the accuracy of cardiac auscultation in warmblood horses and the influence of the grade of regurgitation and dimensional changes on the loudness of the murmur. In this retrospective study, 822 warmblood horses presented for cardiac examination in a large equine referral center in northern Germany underwent a thorough cardiac auscultation. In total, 653 of these revealed one or more heart murmurs. Most common auscultatory findings were left-sided systolic murmurs (68%) or left-sided diastolic murmurs (15%). On 635 of these horses, an echocardiographic examination was performed, revealing regurgitations of the mitral valve as the most common valvular regurgitation (77%) followed by regurgitations of the aortic valve (23%). Thirty-one percent of horses that underwent echocardiographic examination displayed dimensional changes of one or more compartments of the heart, with the left atrium being most affected (21%), followed by the left ventricle (13%). The main goal of this study was to link certain auscultatory findings with results of the echocardiographic examinations, trying to determine whether auscultation and echocardiography agreed on the valve affected, as well as to find out if loudness of the murmur coincided with grade of regurgitation and presence of dimensional changes. Agreement between auscultation and cardiac ultrasound was substantial (Kappa 0.74) if one or more murmurs and regurgitations were present and almost perfect (Kappa 0.94) if only one murmur and one regurgitation were found. Auscultation was particularly well suited for detection of left-sided systolic and diastolic murmurs, with 87% of left-sided systolic murmurs being caused by a mitral valve regurgitation and 81% of left-sided diastolic murmurs originating from an aortic valve regurgitation. We found a fair agreement between the grade of regurgitation and the respective murmur. Association was particularly good between mild regurgitations and low-grade murmurs, while differentiation between moderate to severe regurgitation based upon the loudness of the murmur was less reliable. Dimensional changes were usually linked to more severe regurgitations and higher-grade murmurs. However, a direct correlation between murmur intensity and the presence or severity of dimensional changes, independent of the grade of valvular regurgitation, could not be established in this cohort of horses.</description><identifier>ISSN: 2076-2615</identifier><identifier>EISSN: 2076-2615</identifier><identifier>DOI: 10.3390/ani11123463</identifier><identifier>PMID: 34944240</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Agriculture ; Agriculture, Dairy &amp; Animal Science ; Aorta ; Aortic valve ; Archives &amp; records ; Atria ; Auscultation ; Cardiac arrhythmia ; cardiology ; Cardiovascular system ; Compartments ; Differentiation ; Echocardiography ; equine ; Heart ; heart murmur ; Heart valves ; Horses ; Life Sciences &amp; Biomedicine ; Loudness ; Mitral valve ; Physiology ; Regurgitation ; Science &amp; Technology ; Statistical analysis ; valvular regurgitation ; Ventricle ; Veterinary Sciences ; Zoology</subject><ispartof>Animals (Basel), 2021-12, Vol.11 (12), p.3463, Article 3463</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000735260300001</woscitedreferencesoriginalsourcerecordid><cites>FETCH-LOGICAL-c433t-aa0335fe6bebcbf64951b3a6204a186e546088fbd371ae4461918bf9841a0e243</cites><orcidid>0000-0001-5451-4232 ; 0000-0002-8688-2926</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698104/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698104/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34944240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoevener, Jakob</creatorcontrib><creatorcontrib>Pokar, Julie</creatorcontrib><creatorcontrib>Merle, Roswitha</creatorcontrib><creatorcontrib>Gehlen, Heidrun</creatorcontrib><title>Association between Cardiac Auscultation and Echocardiographic Findings in Warmblood Horses</title><title>Animals (Basel)</title><addtitle>ANIMALS-BASEL</addtitle><addtitle>Animals (Basel)</addtitle><description>Simple Summary In our study, we retrospectively analyzed cardiac examinations in a large number of warmblood horses conducted over a period of almost 20 years. 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Limited information exists about the accuracy of these broad rules in warmblood horses and the influence of grade of the regurgitation and dimensional changes on murmur intensity. This study aims to clarify the accuracy of cardiac auscultation in warmblood horses and the influence of the grade of regurgitation and dimensional changes on the loudness of the murmur. In this retrospective study, 822 warmblood horses presented for cardiac examination in a large equine referral center in northern Germany underwent a thorough cardiac auscultation. In total, 653 of these revealed one or more heart murmurs. Most common auscultatory findings were left-sided systolic murmurs (68%) or left-sided diastolic murmurs (15%). On 635 of these horses, an echocardiographic examination was performed, revealing regurgitations of the mitral valve as the most common valvular regurgitation (77%) followed by regurgitations of the aortic valve (23%). Thirty-one percent of horses that underwent echocardiographic examination displayed dimensional changes of one or more compartments of the heart, with the left atrium being most affected (21%), followed by the left ventricle (13%). The main goal of this study was to link certain auscultatory findings with results of the echocardiographic examinations, trying to determine whether auscultation and echocardiography agreed on the valve affected, as well as to find out if loudness of the murmur coincided with grade of regurgitation and presence of dimensional changes. Agreement between auscultation and cardiac ultrasound was substantial (Kappa 0.74) if one or more murmurs and regurgitations were present and almost perfect (Kappa 0.94) if only one murmur and one regurgitation were found. Auscultation was particularly well suited for detection of left-sided systolic and diastolic murmurs, with 87% of left-sided systolic murmurs being caused by a mitral valve regurgitation and 81% of left-sided diastolic murmurs originating from an aortic valve regurgitation. We found a fair agreement between the grade of regurgitation and the respective murmur. Association was particularly good between mild regurgitations and low-grade murmurs, while differentiation between moderate to severe regurgitation based upon the loudness of the murmur was less reliable. Dimensional changes were usually linked to more severe regurgitations and higher-grade murmurs. However, a direct correlation between murmur intensity and the presence or severity of dimensional changes, independent of the grade of valvular regurgitation, could not be established in this cohort of horses.</description><subject>Agriculture</subject><subject>Agriculture, Dairy &amp; Animal Science</subject><subject>Aorta</subject><subject>Aortic valve</subject><subject>Archives &amp; records</subject><subject>Atria</subject><subject>Auscultation</subject><subject>Cardiac arrhythmia</subject><subject>cardiology</subject><subject>Cardiovascular system</subject><subject>Compartments</subject><subject>Differentiation</subject><subject>Echocardiography</subject><subject>equine</subject><subject>Heart</subject><subject>heart murmur</subject><subject>Heart valves</subject><subject>Horses</subject><subject>Life Sciences &amp; Biomedicine</subject><subject>Loudness</subject><subject>Mitral valve</subject><subject>Physiology</subject><subject>Regurgitation</subject><subject>Science &amp; Technology</subject><subject>Statistical analysis</subject><subject>valvular regurgitation</subject><subject>Ventricle</subject><subject>Veterinary Sciences</subject><subject>Zoology</subject><issn>2076-2615</issn><issn>2076-2615</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNks-L1DAUx4so7rLuybsUvAgymt9NL8JQdt2FBS-KBw_hJX2dydBJxqR18b-3tes468lcEt775MuX975F8ZKSd5zX5D0ETyllXCj-pDhnpFIrpqh8evI-Ky5z3pHpVJJTSZ8XZ1zUQjBBzotv65yj8zD4GEqLwz1iKBtIrQdXrsfsxn5YmhDa8spto5ubcZPgsPWuvPah9WGTSx_Kr5D2to-xLW9iyphfFM866DNePtwXxZfrq8_Nzeru08fbZn23coLzYQVAOJcdKovW2U6JWlLLQTEigGqFUiiidWdbXlFAIRStqbZdrQUFgkzwi-J20W0j7Mwh-T2knyaCN78LMW0MpMG7Ho1QQsnWcqmFFASkbmtE11EUdctAqUnrw6J1GO0eW4dhSNA_En3cCX5rNvGH0arWlMxm3jwIpPh9xDyYvc8O-x4CxjGbaSPT5Jkm1YS-_gfdxTGFaVQzxSrGeTULvl0ol2LOCbujGUrMnAFzkoGJfnXq_8j-2fgE6AW4Rxu77DwGh0dsDgmXTBE-54U2fll-E8cw_HXyP1_5L_M1zNU</recordid><startdate>20211205</startdate><enddate>20211205</enddate><creator>Hoevener, Jakob</creator><creator>Pokar, Julie</creator><creator>Merle, Roswitha</creator><creator>Gehlen, Heidrun</creator><general>Mdpi</general><general>MDPI AG</general><general>MDPI</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5451-4232</orcidid><orcidid>https://orcid.org/0000-0002-8688-2926</orcidid></search><sort><creationdate>20211205</creationdate><title>Association between Cardiac Auscultation and Echocardiographic Findings in Warmblood Horses</title><author>Hoevener, Jakob ; Pokar, Julie ; Merle, Roswitha ; Gehlen, Heidrun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-aa0335fe6bebcbf64951b3a6204a186e546088fbd371ae4461918bf9841a0e243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Agriculture</topic><topic>Agriculture, Dairy &amp; Animal Science</topic><topic>Aorta</topic><topic>Aortic valve</topic><topic>Archives &amp; records</topic><topic>Atria</topic><topic>Auscultation</topic><topic>Cardiac arrhythmia</topic><topic>cardiology</topic><topic>Cardiovascular system</topic><topic>Compartments</topic><topic>Differentiation</topic><topic>Echocardiography</topic><topic>equine</topic><topic>Heart</topic><topic>heart murmur</topic><topic>Heart valves</topic><topic>Horses</topic><topic>Life Sciences &amp; Biomedicine</topic><topic>Loudness</topic><topic>Mitral valve</topic><topic>Physiology</topic><topic>Regurgitation</topic><topic>Science &amp; Technology</topic><topic>Statistical analysis</topic><topic>valvular regurgitation</topic><topic>Ventricle</topic><topic>Veterinary Sciences</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoevener, Jakob</creatorcontrib><creatorcontrib>Pokar, Julie</creatorcontrib><creatorcontrib>Merle, Roswitha</creatorcontrib><creatorcontrib>Gehlen, Heidrun</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Animals (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoevener, Jakob</au><au>Pokar, Julie</au><au>Merle, Roswitha</au><au>Gehlen, Heidrun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Cardiac Auscultation and Echocardiographic Findings in Warmblood Horses</atitle><jtitle>Animals (Basel)</jtitle><stitle>ANIMALS-BASEL</stitle><addtitle>Animals (Basel)</addtitle><date>2021-12-05</date><risdate>2021</risdate><volume>11</volume><issue>12</issue><spage>3463</spage><pages>3463-</pages><artnum>3463</artnum><issn>2076-2615</issn><eissn>2076-2615</eissn><abstract>Simple Summary In our study, we retrospectively analyzed cardiac examinations in a large number of warmblood horses conducted over a period of almost 20 years. We compared the results of the cardiac auscultation as the character and grade of a heart murmur with the results of the echocardiographic examination. We found that auscultation works very well to identify the valve affected, if following the general clinical guidelines on which kind of murmur is usually caused by specific valvular regurgitations. Auscultation is less specific in determining the grade of the regurgitation based on the loudness of the murmur. Only low-grade murmurs are usually caused by mild regurgitations, while differentiation between moderate and severe regurgitations based on the loudness of the murmur is not reliable. Moreover, we could not find that enlargement of one or more compartments of the heart generally leads to a higher-grade murmur. Heart murmurs are detected frequently when auscultating horses and certain murmurs can usually be linked to specific valvular regurgitations. Limited information exists about the accuracy of these broad rules in warmblood horses and the influence of grade of the regurgitation and dimensional changes on murmur intensity. This study aims to clarify the accuracy of cardiac auscultation in warmblood horses and the influence of the grade of regurgitation and dimensional changes on the loudness of the murmur. In this retrospective study, 822 warmblood horses presented for cardiac examination in a large equine referral center in northern Germany underwent a thorough cardiac auscultation. In total, 653 of these revealed one or more heart murmurs. Most common auscultatory findings were left-sided systolic murmurs (68%) or left-sided diastolic murmurs (15%). On 635 of these horses, an echocardiographic examination was performed, revealing regurgitations of the mitral valve as the most common valvular regurgitation (77%) followed by regurgitations of the aortic valve (23%). Thirty-one percent of horses that underwent echocardiographic examination displayed dimensional changes of one or more compartments of the heart, with the left atrium being most affected (21%), followed by the left ventricle (13%). The main goal of this study was to link certain auscultatory findings with results of the echocardiographic examinations, trying to determine whether auscultation and echocardiography agreed on the valve affected, as well as to find out if loudness of the murmur coincided with grade of regurgitation and presence of dimensional changes. Agreement between auscultation and cardiac ultrasound was substantial (Kappa 0.74) if one or more murmurs and regurgitations were present and almost perfect (Kappa 0.94) if only one murmur and one regurgitation were found. Auscultation was particularly well suited for detection of left-sided systolic and diastolic murmurs, with 87% of left-sided systolic murmurs being caused by a mitral valve regurgitation and 81% of left-sided diastolic murmurs originating from an aortic valve regurgitation. We found a fair agreement between the grade of regurgitation and the respective murmur. Association was particularly good between mild regurgitations and low-grade murmurs, while differentiation between moderate to severe regurgitation based upon the loudness of the murmur was less reliable. Dimensional changes were usually linked to more severe regurgitations and higher-grade murmurs. However, a direct correlation between murmur intensity and the presence or severity of dimensional changes, independent of the grade of valvular regurgitation, could not be established in this cohort of horses.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>34944240</pmid><doi>10.3390/ani11123463</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-5451-4232</orcidid><orcidid>https://orcid.org/0000-0002-8688-2926</orcidid><oa>free_for_read</oa></addata></record>
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subjects Agriculture
Agriculture, Dairy & Animal Science
Aorta
Aortic valve
Archives & records
Atria
Auscultation
Cardiac arrhythmia
cardiology
Cardiovascular system
Compartments
Differentiation
Echocardiography
equine
Heart
heart murmur
Heart valves
Horses
Life Sciences & Biomedicine
Loudness
Mitral valve
Physiology
Regurgitation
Science & Technology
Statistical analysis
valvular regurgitation
Ventricle
Veterinary Sciences
Zoology
title Association between Cardiac Auscultation and Echocardiographic Findings in Warmblood Horses
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