An RCT of acute health effects in COPD-patients after passive vape exposure from e-cigarettes
Background: E-cigarette use has been shown to have short-term acute effects among active users but less is known of the acute passive effects, particularly among individuals with existing respiratory diseases. Objective: To investigate local and systemic effects of short-term passive vape exposure a...
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| Veröffentlicht in: | European clinical respiratory journal 2021-01, Vol.8 (1), p.1861580 |
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| creator | Rosenkilde Laursen, Karin Bønløkke, Jakob Hjort Bendstrup, Elisabeth Bilde, Merete Glasius, Marianne Heitmann Gutzke, Vibeke Puthukkadan Moosakutty, Shamjad Olin, Anna-Carin Ravn, Peter Østergaard, Kirsten Sigsgaard, Torben |
| description | Background: E-cigarette use has been shown to have short-term acute effects among active users but less is known of the acute passive effects, particularly among individuals with existing respiratory diseases.
Objective: To investigate local and systemic effects of short-term passive vape exposure among patients with mild or moderate chronic obstructive pulmonary disease (COPD).
Methods: In a double-blinded crossover study 16 non-smoking COPD-patients (mean age 68) were randomly exposed for 4 h to passive vape (median PM
2.5
: 18 µg/m
3
(range: 8-333)) and clean air (PM
2.5
|
| doi_str_mv | 10.1080/20018525.2020.1861580 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_2612563604</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_207e4b7dd41f4b8886327f409c1bb659</doaj_id><sourcerecordid>2612563604</sourcerecordid><originalsourceid>FETCH-LOGICAL-c600t-68073bbe88af0bd44a3cbeb350aa110432c41a65b0a80ebebe7a50f14490fc33</originalsourceid><addsrcrecordid>eNp9Uk1rGzEUXEpLE9z8hBZBz5s-rT5WvpQG9ysQSCm-FvFW-2SvsVdbaddp_n3l2gnJpSdJM_PmiWGK4i2HSw4GPlQA3KhKXVZQZchorgy8KM4PeHkgXj65nxUXKW0gP9VcGlCvizMhpNJ1Zc6LX1c9-7lYsuAZumkktibcjmtG3pMbE-t6trj98bkccOyozwD6kSIbMKVuT2yPAzH6M4Q0RWI-hh2j0nUrjDSOlN4UrzxuE12czlmx_Pplufhe3tx-u15c3ZROA4ylNlCLpiFj0EPTSonCNdQIBYicgxSVkxy1agANUGaoRgWeSzkH74SYFddH2zbgxg6x22G8twE7-w8IcWUxjp3bkq2gJtnUbSu5l40xRouq9hLmjjeNVvPsVR690h0NU_PMbTUNNkOrySayIuepIes_HvVZvKPW5ZAibp-NPWf6bm1XYW_r2vC51Nng_ckght8TpdFuwhT7HJetNK-UFjonMCvUUeViSCmSf9zAwR46YR86YQ-dsKdO5Ll3T7_3OPXQgCz4dBR0vQ9xh3chbls74v02RB-xd12y4v87_gJmNsXM</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2612563604</pqid></control><display><type>article</type><title>An RCT of acute health effects in COPD-patients after passive vape exposure from e-cigarettes</title><source>DOAJ Directory of Open Access Journals</source><source>Access via Taylor & Francis (Open Access Collection)</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><source>PubMed Central Open Access</source><creator>Rosenkilde Laursen, Karin ; Bønløkke, Jakob Hjort ; Bendstrup, Elisabeth ; Bilde, Merete ; Glasius, Marianne ; Heitmann Gutzke, Vibeke ; Puthukkadan Moosakutty, Shamjad ; Olin, Anna-Carin ; Ravn, Peter ; Østergaard, Kirsten ; Sigsgaard, Torben</creator><creatorcontrib>Rosenkilde Laursen, Karin ; Bønløkke, Jakob Hjort ; Bendstrup, Elisabeth ; Bilde, Merete ; Glasius, Marianne ; Heitmann Gutzke, Vibeke ; Puthukkadan Moosakutty, Shamjad ; Olin, Anna-Carin ; Ravn, Peter ; Østergaard, Kirsten ; Sigsgaard, Torben</creatorcontrib><description>Background: E-cigarette use has been shown to have short-term acute effects among active users but less is known of the acute passive effects, particularly among individuals with existing respiratory diseases.
Objective: To investigate local and systemic effects of short-term passive vape exposure among patients with mild or moderate chronic obstructive pulmonary disease (COPD).
Methods: In a double-blinded crossover study 16 non-smoking COPD-patients (mean age 68) were randomly exposed for 4 h to passive vape (median PM
2.5
: 18 µg/m
3
(range: 8-333)) and clean air (PM
2.5
< 6 µg/m
3
) separated by 14 days. Particles were measured using an ultrafine particle counter (P-TRAK) and a scanning mobility particle sizer (SMPS). Health effects including Surfactant Protein-A (SP-A) and albumin in exhaled air, spirometry, FeNO, and plasma proteins were evaluated before, right after, and 24 hours after exposure. Participants reported symptoms throughout exposure sessions. Data were analyzed using mixed models.
Results: SP-A in exhaled air was negatively affected by exposure to vape and several plasma proteins increased significantly. Throat irritation was more pronounced during passive vape exposure, while FVC and FEV
1
decreased, however, not significantly.
Conclusions: SP-A in exhaled air and some plasma proteins were affected by passive vape in patients with COPD indicating inflammation, showing that passive vape exposure is potentially harmful.</description><identifier>ISSN: 2001-8525</identifier><identifier>EISSN: 2001-8525</identifier><identifier>DOI: 10.1080/20018525.2020.1861580</identifier><identifier>PMID: 33456728</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Chronic obstructive pulmonary disease ; COPD ; Electronic cigarettes ; Electronic nicotine delivery systems ; exposure ; human ; human exposure ; Lungmedicin och allergi ; particulate matter ; Proteins ; RCT ; Respiratory Medicine and Allergy ; Respiratory System ; secondhand vape ; spirometry ; Vaping</subject><ispartof>European clinical respiratory journal, 2021-01, Vol.8 (1), p.1861580</ispartof><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c600t-68073bbe88af0bd44a3cbeb350aa110432c41a65b0a80ebebe7a50f14490fc33</citedby><cites>FETCH-LOGICAL-c600t-68073bbe88af0bd44a3cbeb350aa110432c41a65b0a80ebebe7a50f14490fc33</cites><orcidid>0000-0002-4404-6989 ; 0000-0002-2043-7571 ; 0000-0002-1955-6661 ; 0000-0002-4238-6963 ; 0000-0002-8247-6576 ; 0000-0003-1621-8058 ; 0000-0002-2112-514X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781946/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781946/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27502,27924,27925,53791,53793,59143,59144</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33456728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/301560$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenkilde Laursen, Karin</creatorcontrib><creatorcontrib>Bønløkke, Jakob Hjort</creatorcontrib><creatorcontrib>Bendstrup, Elisabeth</creatorcontrib><creatorcontrib>Bilde, Merete</creatorcontrib><creatorcontrib>Glasius, Marianne</creatorcontrib><creatorcontrib>Heitmann Gutzke, Vibeke</creatorcontrib><creatorcontrib>Puthukkadan Moosakutty, Shamjad</creatorcontrib><creatorcontrib>Olin, Anna-Carin</creatorcontrib><creatorcontrib>Ravn, Peter</creatorcontrib><creatorcontrib>Østergaard, Kirsten</creatorcontrib><creatorcontrib>Sigsgaard, Torben</creatorcontrib><title>An RCT of acute health effects in COPD-patients after passive vape exposure from e-cigarettes</title><title>European clinical respiratory journal</title><addtitle>Eur Clin Respir J</addtitle><description>Background: E-cigarette use has been shown to have short-term acute effects among active users but less is known of the acute passive effects, particularly among individuals with existing respiratory diseases.
Objective: To investigate local and systemic effects of short-term passive vape exposure among patients with mild or moderate chronic obstructive pulmonary disease (COPD).
Methods: In a double-blinded crossover study 16 non-smoking COPD-patients (mean age 68) were randomly exposed for 4 h to passive vape (median PM
2.5
: 18 µg/m
3
(range: 8-333)) and clean air (PM
2.5
< 6 µg/m
3
) separated by 14 days. Particles were measured using an ultrafine particle counter (P-TRAK) and a scanning mobility particle sizer (SMPS). Health effects including Surfactant Protein-A (SP-A) and albumin in exhaled air, spirometry, FeNO, and plasma proteins were evaluated before, right after, and 24 hours after exposure. Participants reported symptoms throughout exposure sessions. Data were analyzed using mixed models.
Results: SP-A in exhaled air was negatively affected by exposure to vape and several plasma proteins increased significantly. Throat irritation was more pronounced during passive vape exposure, while FVC and FEV
1
decreased, however, not significantly.
Conclusions: SP-A in exhaled air and some plasma proteins were affected by passive vape in patients with COPD indicating inflammation, showing that passive vape exposure is potentially harmful.</description><subject>Chronic obstructive pulmonary disease</subject><subject>COPD</subject><subject>Electronic cigarettes</subject><subject>Electronic nicotine delivery systems</subject><subject>exposure</subject><subject>human</subject><subject>human exposure</subject><subject>Lungmedicin och allergi</subject><subject>particulate matter</subject><subject>Proteins</subject><subject>RCT</subject><subject>Respiratory Medicine and Allergy</subject><subject>Respiratory System</subject><subject>secondhand vape</subject><subject>spirometry</subject><subject>Vaping</subject><issn>2001-8525</issn><issn>2001-8525</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNp9Uk1rGzEUXEpLE9z8hBZBz5s-rT5WvpQG9ysQSCm-FvFW-2SvsVdbaddp_n3l2gnJpSdJM_PmiWGK4i2HSw4GPlQA3KhKXVZQZchorgy8KM4PeHkgXj65nxUXKW0gP9VcGlCvizMhpNJ1Zc6LX1c9-7lYsuAZumkktibcjmtG3pMbE-t6trj98bkccOyozwD6kSIbMKVuT2yPAzH6M4Q0RWI-hh2j0nUrjDSOlN4UrzxuE12czlmx_Pplufhe3tx-u15c3ZROA4ylNlCLpiFj0EPTSonCNdQIBYicgxSVkxy1agANUGaoRgWeSzkH74SYFddH2zbgxg6x22G8twE7-w8IcWUxjp3bkq2gJtnUbSu5l40xRouq9hLmjjeNVvPsVR690h0NU_PMbTUNNkOrySayIuepIes_HvVZvKPW5ZAibp-NPWf6bm1XYW_r2vC51Nng_ckght8TpdFuwhT7HJetNK-UFjonMCvUUeViSCmSf9zAwR46YR86YQ-dsKdO5Ll3T7_3OPXQgCz4dBR0vQ9xh3chbls74v02RB-xd12y4v87_gJmNsXM</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Rosenkilde Laursen, Karin</creator><creator>Bønløkke, Jakob Hjort</creator><creator>Bendstrup, Elisabeth</creator><creator>Bilde, Merete</creator><creator>Glasius, Marianne</creator><creator>Heitmann Gutzke, Vibeke</creator><creator>Puthukkadan Moosakutty, Shamjad</creator><creator>Olin, Anna-Carin</creator><creator>Ravn, Peter</creator><creator>Østergaard, Kirsten</creator><creator>Sigsgaard, Torben</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4404-6989</orcidid><orcidid>https://orcid.org/0000-0002-2043-7571</orcidid><orcidid>https://orcid.org/0000-0002-1955-6661</orcidid><orcidid>https://orcid.org/0000-0002-4238-6963</orcidid><orcidid>https://orcid.org/0000-0002-8247-6576</orcidid><orcidid>https://orcid.org/0000-0003-1621-8058</orcidid><orcidid>https://orcid.org/0000-0002-2112-514X</orcidid></search><sort><creationdate>20210101</creationdate><title>An RCT of acute health effects in COPD-patients after passive vape exposure from e-cigarettes</title><author>Rosenkilde Laursen, Karin ; Bønløkke, Jakob Hjort ; Bendstrup, Elisabeth ; Bilde, Merete ; Glasius, Marianne ; Heitmann Gutzke, Vibeke ; Puthukkadan Moosakutty, Shamjad ; Olin, Anna-Carin ; Ravn, Peter ; Østergaard, Kirsten ; Sigsgaard, Torben</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c600t-68073bbe88af0bd44a3cbeb350aa110432c41a65b0a80ebebe7a50f14490fc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chronic obstructive pulmonary disease</topic><topic>COPD</topic><topic>Electronic cigarettes</topic><topic>Electronic nicotine delivery systems</topic><topic>exposure</topic><topic>human</topic><topic>human exposure</topic><topic>Lungmedicin och allergi</topic><topic>particulate matter</topic><topic>Proteins</topic><topic>RCT</topic><topic>Respiratory Medicine and Allergy</topic><topic>Respiratory System</topic><topic>secondhand vape</topic><topic>spirometry</topic><topic>Vaping</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenkilde Laursen, Karin</creatorcontrib><creatorcontrib>Bønløkke, Jakob Hjort</creatorcontrib><creatorcontrib>Bendstrup, Elisabeth</creatorcontrib><creatorcontrib>Bilde, Merete</creatorcontrib><creatorcontrib>Glasius, Marianne</creatorcontrib><creatorcontrib>Heitmann Gutzke, Vibeke</creatorcontrib><creatorcontrib>Puthukkadan Moosakutty, Shamjad</creatorcontrib><creatorcontrib>Olin, Anna-Carin</creatorcontrib><creatorcontrib>Ravn, Peter</creatorcontrib><creatorcontrib>Østergaard, Kirsten</creatorcontrib><creatorcontrib>Sigsgaard, Torben</creatorcontrib><collection>Access via Taylor & Francis (Open Access Collection)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>European clinical respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenkilde Laursen, Karin</au><au>Bønløkke, Jakob Hjort</au><au>Bendstrup, Elisabeth</au><au>Bilde, Merete</au><au>Glasius, Marianne</au><au>Heitmann Gutzke, Vibeke</au><au>Puthukkadan Moosakutty, Shamjad</au><au>Olin, Anna-Carin</au><au>Ravn, Peter</au><au>Østergaard, Kirsten</au><au>Sigsgaard, Torben</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An RCT of acute health effects in COPD-patients after passive vape exposure from e-cigarettes</atitle><jtitle>European clinical respiratory journal</jtitle><addtitle>Eur Clin Respir J</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>8</volume><issue>1</issue><spage>1861580</spage><pages>1861580-</pages><issn>2001-8525</issn><eissn>2001-8525</eissn><abstract>Background: E-cigarette use has been shown to have short-term acute effects among active users but less is known of the acute passive effects, particularly among individuals with existing respiratory diseases.
Objective: To investigate local and systemic effects of short-term passive vape exposure among patients with mild or moderate chronic obstructive pulmonary disease (COPD).
Methods: In a double-blinded crossover study 16 non-smoking COPD-patients (mean age 68) were randomly exposed for 4 h to passive vape (median PM
2.5
: 18 µg/m
3
(range: 8-333)) and clean air (PM
2.5
< 6 µg/m
3
) separated by 14 days. Particles were measured using an ultrafine particle counter (P-TRAK) and a scanning mobility particle sizer (SMPS). Health effects including Surfactant Protein-A (SP-A) and albumin in exhaled air, spirometry, FeNO, and plasma proteins were evaluated before, right after, and 24 hours after exposure. Participants reported symptoms throughout exposure sessions. Data were analyzed using mixed models.
Results: SP-A in exhaled air was negatively affected by exposure to vape and several plasma proteins increased significantly. Throat irritation was more pronounced during passive vape exposure, while FVC and FEV
1
decreased, however, not significantly.
Conclusions: SP-A in exhaled air and some plasma proteins were affected by passive vape in patients with COPD indicating inflammation, showing that passive vape exposure is potentially harmful.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>33456728</pmid><doi>10.1080/20018525.2020.1861580</doi><orcidid>https://orcid.org/0000-0002-4404-6989</orcidid><orcidid>https://orcid.org/0000-0002-2043-7571</orcidid><orcidid>https://orcid.org/0000-0002-1955-6661</orcidid><orcidid>https://orcid.org/0000-0002-4238-6963</orcidid><orcidid>https://orcid.org/0000-0002-8247-6576</orcidid><orcidid>https://orcid.org/0000-0003-1621-8058</orcidid><orcidid>https://orcid.org/0000-0002-2112-514X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | European clinical respiratory journal, 2021-01, Vol.8 (1), p.1861580 |
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| source | DOAJ Directory of Open Access Journals; Access via Taylor & Francis (Open Access Collection); PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Chronic obstructive pulmonary disease COPD Electronic cigarettes Electronic nicotine delivery systems exposure human human exposure Lungmedicin och allergi particulate matter Proteins RCT Respiratory Medicine and Allergy Respiratory System secondhand vape spirometry Vaping |
| title | An RCT of acute health effects in COPD-patients after passive vape exposure from e-cigarettes |
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