SARS-CoV-2 seroprevalence in health care workers from 10 hospitals in Quebec, Canada: a cross-sectional study
Background: The COVID-19 pandemic has disproportionately affected health care workers. We sought to estimate SARS-CoV-2 seroprevalence among hospital health care workers in Quebec, Canada, after the first wave of the pandemic and to explore factors associated with SARS-CoV-2 seropositivity. Methods:...
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| Veröffentlicht in: | Canadian Medical Association journal (CMAJ) 2021-12, Vol.193 (49), p.E1868-E1877 |
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| creator | Brousseau, Nicholas Morin, Laurianne Ouakki, Manale Savard, Patrice Quach, Caroline Longtin, Yves Cheng, Matthew P. Carignan, Alex Dufresne, Simon F. Leduc, Jean-Michel Lavallee, Christian Gauthier, Nicolas Bestman-Smith, Julie Arrieta, Maria-Jesus Ishak, Magued Levesque, Simon Martin, Philippe De Serres, Gaston |
| description | Background: The COVID-19 pandemic has disproportionately affected health care workers. We sought to estimate SARS-CoV-2 seroprevalence among hospital health care workers in Quebec, Canada, after the first wave of the pandemic and to explore factors associated with SARS-CoV-2 seropositivity. Methods: Between July 6 and Sept. 24, 2020, we enrolled health care workers from 10 hospitals, including 8 from a region with a high incidence of COVID-19 (the Montreal area) and 2 from low-incidence regions of Quebec. Eligible health care workers were physicians, nurses, orderlies and cleaning staff working in 4 types of care units (emergency department, intensive care unit, COVID-19 inpatient unit and non-COVID-19 inpatient unit). Participants completed a questionnaire and underwent SARS-CoV-2 serology testing. We identified factors independently associated with higher seroprevalence. Results: Among 2056 enrolled health care workers, 241 (11.7%) had positive SARS-CoV-2 serology. Of these, 171 (71.0%) had been previously diagnosed with COVID-19. Seroprevalence varied among hospitals, from 2.4% to 3.7% in low-incidence regions to 17.9% to 32.0% in hospitals with outbreaks involving 5 or more health care workers. Higher seroprevalence was associated with working in a hospital where outbreaks occurred (adjusted prevalence ratio 4.16, 95% confidence interval [CI] 2.63-6.57), being a nurse or nursing assistant (adjusted prevalence ratio 1.34, 95% CI 1.03-1.74) or an orderly (adjusted prevalence ratio 1.49, 95% CI 1.12-1.97), and Black or Hispanic ethnicity (adjusted prevalence ratio 1.41, 95% CI 1.13-1.76). Lower seroprevalence was associated with working in the intensive care unit (adjusted prevalence ratio 0.47, 95% CI 0.30-0.71) or the emergency department (adjusted prevalence ratio 0.61, 95% CI 0.39-0.98). Interpretation: Health care workers in Quebec hospitals were at high risk of SARS-CoV-2 infection, particularly in outbreak settings. More work is needed to better understand SARS-CoV-2 transmission dynamics in health care settings. |
| doi_str_mv | 10.1503/cmaj.202783 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2612312922</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A687003754</galeid><sourcerecordid>A687003754</sourcerecordid><originalsourceid>FETCH-LOGICAL-c640t-796e28c5fa7f56d7727c407113790d19695ed9e5c3ef71daabda0fae2003b8653</originalsourceid><addsrcrecordid>eNqVks1v0zAYhy0EYqVw4o4sJiEhSPFHEicckKqIj0kTiBW4Wq7zpnVJ4sxONvbf49DRtVIPYB8s2Y9__ngfhJ5SMqMJ4W90ozYzRpjI-D00oXGWRYyz_D6akIyRiOdxeoIeeb8hoXEmHqITHueEJzmdoGYxv1hEhf0RMezB2c7Blaqh1YBNi9eg6n6NtXKAr637Cc7jytkGU4LX1nemV7Ufwa8DLEG_xoVqVaneYoW1s95HHnRvbKtq7PuhvHmMHlRhBzy5Hafo-4f334pP0fmXj2fF_DzSaUz6SOQpsEwnlRJVkpZCMKFjIijlIiclzdM8gTKHRHOoBC2VWpaKVApYeN8ySxM-Re-2ud2wbKDU0PZO1bJzplHuRlpl5OFKa9ZyZa9klgqRhI-cotPbAGcvB_C93NjBhXd4yVLKOGU5Y3fUKnyZNG1lQ5hujNdynmYi3EYkcaCiI9QKWggn2xYqE6YP-OdHeN2ZS7kPzY5AoZfQGH009eXBhsD08KtfqcF7eba4-A_28yH7Yo_dCuNtPYxl94fgqy34xwwH1a4clMhRZDmKLLciB_rZfgV37F9z7-KuYWkrr83o7A4LpgtOSRKPzpORzv6dLoLW4_ULO7Q9_w3PnAmN</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2612312922</pqid></control><display><type>article</type><title>SARS-CoV-2 seroprevalence in health care workers from 10 hospitals in Quebec, Canada: a cross-sectional study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Brousseau, Nicholas ; Morin, Laurianne ; Ouakki, Manale ; Savard, Patrice ; Quach, Caroline ; Longtin, Yves ; Cheng, Matthew P. ; Carignan, Alex ; Dufresne, Simon F. ; Leduc, Jean-Michel ; Lavallee, Christian ; Gauthier, Nicolas ; Bestman-Smith, Julie ; Arrieta, Maria-Jesus ; Ishak, Magued ; Levesque, Simon ; Martin, Philippe ; De Serres, Gaston</creator><creatorcontrib>Brousseau, Nicholas ; Morin, Laurianne ; Ouakki, Manale ; Savard, Patrice ; Quach, Caroline ; Longtin, Yves ; Cheng, Matthew P. ; Carignan, Alex ; Dufresne, Simon F. ; Leduc, Jean-Michel ; Lavallee, Christian ; Gauthier, Nicolas ; Bestman-Smith, Julie ; Arrieta, Maria-Jesus ; Ishak, Magued ; Levesque, Simon ; Martin, Philippe ; De Serres, Gaston</creatorcontrib><description>Background: The COVID-19 pandemic has disproportionately affected health care workers. We sought to estimate SARS-CoV-2 seroprevalence among hospital health care workers in Quebec, Canada, after the first wave of the pandemic and to explore factors associated with SARS-CoV-2 seropositivity. Methods: Between July 6 and Sept. 24, 2020, we enrolled health care workers from 10 hospitals, including 8 from a region with a high incidence of COVID-19 (the Montreal area) and 2 from low-incidence regions of Quebec. Eligible health care workers were physicians, nurses, orderlies and cleaning staff working in 4 types of care units (emergency department, intensive care unit, COVID-19 inpatient unit and non-COVID-19 inpatient unit). Participants completed a questionnaire and underwent SARS-CoV-2 serology testing. We identified factors independently associated with higher seroprevalence. Results: Among 2056 enrolled health care workers, 241 (11.7%) had positive SARS-CoV-2 serology. Of these, 171 (71.0%) had been previously diagnosed with COVID-19. Seroprevalence varied among hospitals, from 2.4% to 3.7% in low-incidence regions to 17.9% to 32.0% in hospitals with outbreaks involving 5 or more health care workers. Higher seroprevalence was associated with working in a hospital where outbreaks occurred (adjusted prevalence ratio 4.16, 95% confidence interval [CI] 2.63-6.57), being a nurse or nursing assistant (adjusted prevalence ratio 1.34, 95% CI 1.03-1.74) or an orderly (adjusted prevalence ratio 1.49, 95% CI 1.12-1.97), and Black or Hispanic ethnicity (adjusted prevalence ratio 1.41, 95% CI 1.13-1.76). Lower seroprevalence was associated with working in the intensive care unit (adjusted prevalence ratio 0.47, 95% CI 0.30-0.71) or the emergency department (adjusted prevalence ratio 0.61, 95% CI 0.39-0.98). Interpretation: Health care workers in Quebec hospitals were at high risk of SARS-CoV-2 infection, particularly in outbreak settings. More work is needed to better understand SARS-CoV-2 transmission dynamics in health care settings.</description><identifier>ISSN: 0820-3946</identifier><identifier>EISSN: 1488-2329</identifier><identifier>DOI: 10.1503/cmaj.202783</identifier><identifier>PMID: 34903591</identifier><language>eng</language><publisher>OTTAWA: Cma-Canadian Medical Assoc</publisher><subject>Canada ; Confidence intervals ; Coronaviruses ; COVID-19 ; COVID-19 - blood ; COVID-19 - epidemiology ; COVID-19 - etiology ; Cross-Sectional Studies ; Demography ; Disease transmission ; Epidemics ; Ethnicity ; General & Internal Medicine ; Health aspects ; Health Personnel ; Hospitals ; Humans ; Immunoassay ; Incidence ; Infections ; Intensive care ; Life Sciences & Biomedicine ; Medical personnel ; Medicine, General & Internal ; Occupational Diseases - blood ; Occupational Diseases - epidemiology ; Occupational Diseases - etiology ; Pandemics ; Quebec - epidemiology ; Questionnaires ; Risk Factors ; SARS-CoV-2 ; Science & Technology ; Seroepidemiologic Studies ; Serology ; Severe acute respiratory syndrome coronavirus 2 ; Statistics ; Surveys and Questionnaires</subject><ispartof>Canadian Medical Association journal (CMAJ), 2021-12, Vol.193 (49), p.E1868-E1877</ispartof><rights>2021 CMA Joule Inc. or its licensors.</rights><rights>COPYRIGHT 2021 CMA Joule Inc.</rights><rights>Copyright Joule Inc Dec 13, 2021</rights><rights>2021 CMA Joule Inc. or its licensors 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>12</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000731054000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c640t-796e28c5fa7f56d7727c407113790d19695ed9e5c3ef71daabda0fae2003b8653</citedby><cites>FETCH-LOGICAL-c640t-796e28c5fa7f56d7727c407113790d19695ed9e5c3ef71daabda0fae2003b8653</cites><orcidid>0000-0002-4532-379X ; 0000-0002-4356-9702</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677578/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677578/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2118,27933,27934,39267,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34903591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brousseau, Nicholas</creatorcontrib><creatorcontrib>Morin, Laurianne</creatorcontrib><creatorcontrib>Ouakki, Manale</creatorcontrib><creatorcontrib>Savard, Patrice</creatorcontrib><creatorcontrib>Quach, Caroline</creatorcontrib><creatorcontrib>Longtin, Yves</creatorcontrib><creatorcontrib>Cheng, Matthew P.</creatorcontrib><creatorcontrib>Carignan, Alex</creatorcontrib><creatorcontrib>Dufresne, Simon F.</creatorcontrib><creatorcontrib>Leduc, Jean-Michel</creatorcontrib><creatorcontrib>Lavallee, Christian</creatorcontrib><creatorcontrib>Gauthier, Nicolas</creatorcontrib><creatorcontrib>Bestman-Smith, Julie</creatorcontrib><creatorcontrib>Arrieta, Maria-Jesus</creatorcontrib><creatorcontrib>Ishak, Magued</creatorcontrib><creatorcontrib>Levesque, Simon</creatorcontrib><creatorcontrib>Martin, Philippe</creatorcontrib><creatorcontrib>De Serres, Gaston</creatorcontrib><title>SARS-CoV-2 seroprevalence in health care workers from 10 hospitals in Quebec, Canada: a cross-sectional study</title><title>Canadian Medical Association journal (CMAJ)</title><addtitle>CAN MED ASSOC J</addtitle><addtitle>CMAJ</addtitle><description>Background: The COVID-19 pandemic has disproportionately affected health care workers. We sought to estimate SARS-CoV-2 seroprevalence among hospital health care workers in Quebec, Canada, after the first wave of the pandemic and to explore factors associated with SARS-CoV-2 seropositivity. Methods: Between July 6 and Sept. 24, 2020, we enrolled health care workers from 10 hospitals, including 8 from a region with a high incidence of COVID-19 (the Montreal area) and 2 from low-incidence regions of Quebec. Eligible health care workers were physicians, nurses, orderlies and cleaning staff working in 4 types of care units (emergency department, intensive care unit, COVID-19 inpatient unit and non-COVID-19 inpatient unit). Participants completed a questionnaire and underwent SARS-CoV-2 serology testing. We identified factors independently associated with higher seroprevalence. Results: Among 2056 enrolled health care workers, 241 (11.7%) had positive SARS-CoV-2 serology. Of these, 171 (71.0%) had been previously diagnosed with COVID-19. Seroprevalence varied among hospitals, from 2.4% to 3.7% in low-incidence regions to 17.9% to 32.0% in hospitals with outbreaks involving 5 or more health care workers. Higher seroprevalence was associated with working in a hospital where outbreaks occurred (adjusted prevalence ratio 4.16, 95% confidence interval [CI] 2.63-6.57), being a nurse or nursing assistant (adjusted prevalence ratio 1.34, 95% CI 1.03-1.74) or an orderly (adjusted prevalence ratio 1.49, 95% CI 1.12-1.97), and Black or Hispanic ethnicity (adjusted prevalence ratio 1.41, 95% CI 1.13-1.76). Lower seroprevalence was associated with working in the intensive care unit (adjusted prevalence ratio 0.47, 95% CI 0.30-0.71) or the emergency department (adjusted prevalence ratio 0.61, 95% CI 0.39-0.98). Interpretation: Health care workers in Quebec hospitals were at high risk of SARS-CoV-2 infection, particularly in outbreak settings. More work is needed to better understand SARS-CoV-2 transmission dynamics in health care settings.</description><subject>Canada</subject><subject>Confidence intervals</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - blood</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - etiology</subject><subject>Cross-Sectional Studies</subject><subject>Demography</subject><subject>Disease transmission</subject><subject>Epidemics</subject><subject>Ethnicity</subject><subject>General & Internal Medicine</subject><subject>Health aspects</subject><subject>Health Personnel</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Incidence</subject><subject>Infections</subject><subject>Intensive care</subject><subject>Life Sciences & Biomedicine</subject><subject>Medical personnel</subject><subject>Medicine, General & Internal</subject><subject>Occupational Diseases - blood</subject><subject>Occupational Diseases - epidemiology</subject><subject>Occupational Diseases - etiology</subject><subject>Pandemics</subject><subject>Quebec - epidemiology</subject><subject>Questionnaires</subject><subject>Risk Factors</subject><subject>SARS-CoV-2</subject><subject>Science & Technology</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Statistics</subject><subject>Surveys and Questionnaires</subject><issn>0820-3946</issn><issn>1488-2329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqVks1v0zAYhy0EYqVw4o4sJiEhSPFHEicckKqIj0kTiBW4Wq7zpnVJ4sxONvbf49DRtVIPYB8s2Y9__ngfhJ5SMqMJ4W90ozYzRpjI-D00oXGWRYyz_D6akIyRiOdxeoIeeb8hoXEmHqITHueEJzmdoGYxv1hEhf0RMezB2c7Blaqh1YBNi9eg6n6NtXKAr637Cc7jytkGU4LX1nemV7Ufwa8DLEG_xoVqVaneYoW1s95HHnRvbKtq7PuhvHmMHlRhBzy5Hafo-4f334pP0fmXj2fF_DzSaUz6SOQpsEwnlRJVkpZCMKFjIijlIiclzdM8gTKHRHOoBC2VWpaKVApYeN8ySxM-Re-2ud2wbKDU0PZO1bJzplHuRlpl5OFKa9ZyZa9klgqRhI-cotPbAGcvB_C93NjBhXd4yVLKOGU5Y3fUKnyZNG1lQ5hujNdynmYi3EYkcaCiI9QKWggn2xYqE6YP-OdHeN2ZS7kPzY5AoZfQGH009eXBhsD08KtfqcF7eba4-A_28yH7Yo_dCuNtPYxl94fgqy34xwwH1a4clMhRZDmKLLciB_rZfgV37F9z7-KuYWkrr83o7A4LpgtOSRKPzpORzv6dLoLW4_ULO7Q9_w3PnAmN</recordid><startdate>20211213</startdate><enddate>20211213</enddate><creator>Brousseau, Nicholas</creator><creator>Morin, Laurianne</creator><creator>Ouakki, Manale</creator><creator>Savard, Patrice</creator><creator>Quach, Caroline</creator><creator>Longtin, Yves</creator><creator>Cheng, Matthew P.</creator><creator>Carignan, Alex</creator><creator>Dufresne, Simon F.</creator><creator>Leduc, Jean-Michel</creator><creator>Lavallee, Christian</creator><creator>Gauthier, Nicolas</creator><creator>Bestman-Smith, Julie</creator><creator>Arrieta, Maria-Jesus</creator><creator>Ishak, Magued</creator><creator>Levesque, Simon</creator><creator>Martin, Philippe</creator><creator>De Serres, Gaston</creator><general>Cma-Canadian Medical Assoc</general><general>CMA Joule Inc</general><general>CMA Impact, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M3G</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4532-379X</orcidid><orcidid>https://orcid.org/0000-0002-4356-9702</orcidid></search><sort><creationdate>20211213</creationdate><title>SARS-CoV-2 seroprevalence in health care workers from 10 hospitals in Quebec, Canada: a cross-sectional study</title><author>Brousseau, Nicholas ; Morin, Laurianne ; Ouakki, Manale ; Savard, Patrice ; Quach, Caroline ; Longtin, Yves ; Cheng, Matthew P. ; Carignan, Alex ; Dufresne, Simon F. ; Leduc, Jean-Michel ; Lavallee, Christian ; Gauthier, Nicolas ; Bestman-Smith, Julie ; Arrieta, Maria-Jesus ; Ishak, Magued ; Levesque, Simon ; Martin, Philippe ; De Serres, Gaston</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c640t-796e28c5fa7f56d7727c407113790d19695ed9e5c3ef71daabda0fae2003b8653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Canada</topic><topic>Confidence intervals</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - blood</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - etiology</topic><topic>Cross-Sectional Studies</topic><topic>Demography</topic><topic>Disease transmission</topic><topic>Epidemics</topic><topic>Ethnicity</topic><topic>General & Internal Medicine</topic><topic>Health aspects</topic><topic>Health Personnel</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Incidence</topic><topic>Infections</topic><topic>Intensive care</topic><topic>Life Sciences & Biomedicine</topic><topic>Medical personnel</topic><topic>Medicine, General & Internal</topic><topic>Occupational Diseases - blood</topic><topic>Occupational Diseases - epidemiology</topic><topic>Occupational Diseases - etiology</topic><topic>Pandemics</topic><topic>Quebec - epidemiology</topic><topic>Questionnaires</topic><topic>Risk Factors</topic><topic>SARS-CoV-2</topic><topic>Science & Technology</topic><topic>Seroepidemiologic Studies</topic><topic>Serology</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Statistics</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brousseau, Nicholas</creatorcontrib><creatorcontrib>Morin, Laurianne</creatorcontrib><creatorcontrib>Ouakki, Manale</creatorcontrib><creatorcontrib>Savard, Patrice</creatorcontrib><creatorcontrib>Quach, Caroline</creatorcontrib><creatorcontrib>Longtin, Yves</creatorcontrib><creatorcontrib>Cheng, Matthew P.</creatorcontrib><creatorcontrib>Carignan, Alex</creatorcontrib><creatorcontrib>Dufresne, Simon F.</creatorcontrib><creatorcontrib>Leduc, Jean-Michel</creatorcontrib><creatorcontrib>Lavallee, Christian</creatorcontrib><creatorcontrib>Gauthier, Nicolas</creatorcontrib><creatorcontrib>Bestman-Smith, Julie</creatorcontrib><creatorcontrib>Arrieta, Maria-Jesus</creatorcontrib><creatorcontrib>Ishak, Magued</creatorcontrib><creatorcontrib>Levesque, Simon</creatorcontrib><creatorcontrib>Martin, Philippe</creatorcontrib><creatorcontrib>De Serres, Gaston</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>CBCA Reference & Current Events</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Canadian Medical Association journal (CMAJ)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brousseau, Nicholas</au><au>Morin, Laurianne</au><au>Ouakki, Manale</au><au>Savard, Patrice</au><au>Quach, Caroline</au><au>Longtin, Yves</au><au>Cheng, Matthew P.</au><au>Carignan, Alex</au><au>Dufresne, Simon F.</au><au>Leduc, Jean-Michel</au><au>Lavallee, Christian</au><au>Gauthier, Nicolas</au><au>Bestman-Smith, Julie</au><au>Arrieta, Maria-Jesus</au><au>Ishak, Magued</au><au>Levesque, Simon</au><au>Martin, Philippe</au><au>De Serres, Gaston</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SARS-CoV-2 seroprevalence in health care workers from 10 hospitals in Quebec, Canada: a cross-sectional study</atitle><jtitle>Canadian Medical Association journal (CMAJ)</jtitle><stitle>CAN MED ASSOC J</stitle><addtitle>CMAJ</addtitle><date>2021-12-13</date><risdate>2021</risdate><volume>193</volume><issue>49</issue><spage>E1868</spage><epage>E1877</epage><pages>E1868-E1877</pages><issn>0820-3946</issn><eissn>1488-2329</eissn><abstract>Background: The COVID-19 pandemic has disproportionately affected health care workers. We sought to estimate SARS-CoV-2 seroprevalence among hospital health care workers in Quebec, Canada, after the first wave of the pandemic and to explore factors associated with SARS-CoV-2 seropositivity. Methods: Between July 6 and Sept. 24, 2020, we enrolled health care workers from 10 hospitals, including 8 from a region with a high incidence of COVID-19 (the Montreal area) and 2 from low-incidence regions of Quebec. Eligible health care workers were physicians, nurses, orderlies and cleaning staff working in 4 types of care units (emergency department, intensive care unit, COVID-19 inpatient unit and non-COVID-19 inpatient unit). Participants completed a questionnaire and underwent SARS-CoV-2 serology testing. We identified factors independently associated with higher seroprevalence. Results: Among 2056 enrolled health care workers, 241 (11.7%) had positive SARS-CoV-2 serology. Of these, 171 (71.0%) had been previously diagnosed with COVID-19. Seroprevalence varied among hospitals, from 2.4% to 3.7% in low-incidence regions to 17.9% to 32.0% in hospitals with outbreaks involving 5 or more health care workers. Higher seroprevalence was associated with working in a hospital where outbreaks occurred (adjusted prevalence ratio 4.16, 95% confidence interval [CI] 2.63-6.57), being a nurse or nursing assistant (adjusted prevalence ratio 1.34, 95% CI 1.03-1.74) or an orderly (adjusted prevalence ratio 1.49, 95% CI 1.12-1.97), and Black or Hispanic ethnicity (adjusted prevalence ratio 1.41, 95% CI 1.13-1.76). Lower seroprevalence was associated with working in the intensive care unit (adjusted prevalence ratio 0.47, 95% CI 0.30-0.71) or the emergency department (adjusted prevalence ratio 0.61, 95% CI 0.39-0.98). Interpretation: Health care workers in Quebec hospitals were at high risk of SARS-CoV-2 infection, particularly in outbreak settings. More work is needed to better understand SARS-CoV-2 transmission dynamics in health care settings.</abstract><cop>OTTAWA</cop><pub>Cma-Canadian Medical Assoc</pub><pmid>34903591</pmid><doi>10.1503/cmaj.202783</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4532-379X</orcidid><orcidid>https://orcid.org/0000-0002-4356-9702</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0820-3946 |
| ispartof | Canadian Medical Association journal (CMAJ), 2021-12, Vol.193 (49), p.E1868-E1877 |
| issn | 0820-3946 1488-2329 |
| language | eng |
| recordid | cdi_proquest_journals_2612312922 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; PubMed Central; Alma/SFX Local Collection |
| subjects | Canada Confidence intervals Coronaviruses COVID-19 COVID-19 - blood COVID-19 - epidemiology COVID-19 - etiology Cross-Sectional Studies Demography Disease transmission Epidemics Ethnicity General & Internal Medicine Health aspects Health Personnel Hospitals Humans Immunoassay Incidence Infections Intensive care Life Sciences & Biomedicine Medical personnel Medicine, General & Internal Occupational Diseases - blood Occupational Diseases - epidemiology Occupational Diseases - etiology Pandemics Quebec - epidemiology Questionnaires Risk Factors SARS-CoV-2 Science & Technology Seroepidemiologic Studies Serology Severe acute respiratory syndrome coronavirus 2 Statistics Surveys and Questionnaires |
| title | SARS-CoV-2 seroprevalence in health care workers from 10 hospitals in Quebec, Canada: a cross-sectional study |
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