Extracellular Vesicles from HIF-1 alpha-Overexpressing Adipose-Derived Stem Cells Restore Diabetic Wounds Through Accelerated Fibroblast Proliferation and Migration

Purpose: Inhibition of cellular adaptation to hypoxia can cause persistent inflammation, thereby increasing tissue damage and complicating wound healing in diabetes patients. Regulating cellular adaptation to hypoxic environments can help in effective wound repair. Hypoxia-inducible factor (HIF)-1 a...

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Veröffentlicht in:	International journal of nanomedicine 2021-01, Vol.16, p.7943-7957
Hauptverfasser:	Wang, Jie, Wu, Hao, Zhao, Yue, Qin, Youyou, Zhang, Yingbo, Pang, Hao, Zhou, Yongting, Liu, Xueyi, Xiao, Zhibo
Format:	Artikel
Sprache:	eng
Schlagworte:	adscs Cell growth Cell Proliferation Diabetes Diabetes Mellitus diabetic wound Extracellular matrix Extracellular Vesicles fibroblast Fibroblasts hif-1α Hospitals Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Inflammation Life Sciences & Biomedicine Nanoscience & Nanotechnology Original Research Pharmacology & Pharmacy Phosphatidylinositol 3-Kinases Proteins Science & Technology Science & Technology - Other Topics Stem Cells Wound Healing
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