Clinical Characteristics and Prognosis of HER2 Gene Phenotype in Patients with Non-Small Cell Lung Cancer

Introduction: We aim to investigate the relationship between HER2 gene phenotype and clinical characteristics, distribution and prognosis of non-small cell lung cancer (NSCLC) patients. Methods: A total of 249 NSCLC patients admitted to the oncology department of our hospital from January 2015 to Ja...

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Veröffentlicht in:	International journal of general medicine 2021-01, Vol.14, p.9153-9161
Hauptverfasser:	Diao, Wei-Ying, Ding, Cheng-Long, Yuan, Bo-Yang, Li, Zan, Sun, Na, Huang, Jia-Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	afatinib Cancer Cancer therapies Carboplatin Chemotherapy ct signs Development and progression Drug dosages Gene amplification Gene expression Gene mutations General & Internal Medicine Genes Genetic aspects Genetic screening Genotype & phenotype her2 genotype Hospitals Life Sciences & Biomedicine Lung cancer Lung cancer, Non-small cell Lung cancer, Small cell Medical prognosis Medicine, General & Internal Mutation non-small cell lung cancer Original Research Patients Pemetrexed Prognosis Radiation therapy Science & Technology Signal transduction Tumors
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Zusammenfassung:	Introduction: We aim to investigate the relationship between HER2 gene phenotype and clinical characteristics, distribution and prognosis of non-small cell lung cancer (NSCLC) patients. Methods: A total of 249 NSCLC patients admitted to the oncology department of our hospital from January 2015 to January 2018 were retrospectively analyzed. The clinicopathological information, CT signs, clinical efficacy and long-term prognosis were collected and compared. Results: A total of 249 NSCLC patients underwent HER2 gene testing, 21 of them (8.43%) complied with HER2 alterations [HER2 (+)], and there were significant differences in tumor stages among patients with different HER2 phenotypes (P
ISSN:	1178-7074 1178-7074
DOI:	10.2147/IJGM.S328908